Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jennelle Francis"'
Publikováno v:
Cancer Gene Therapy. 18:734-743
Pancreatic adenocarcinoma has a poor prognosis and frequently develops resistance to standard chemotherapeutics. Oncolytic adenoviruses represent a promising approach to overcome treatment resistance. The replication-selective dl922-947 adenovirus, d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea52948d701a7da363cd3bb42835f5a
https://doi.org/10.1038/cgt.2011.45
https://doi.org/10.1038/cgt.2011.45
Autor:
Yaohe Wang, Liufu Deng, Istvan Fodor, Ziming Dong, Fengyu Cao, Nicholas R. Lemoine, Ghassan Alusi, Shengdian Wang, Shaolong Yang, James R. Tysome, Pengju Wang, Dongling Gao, Jinxia Yu, Arnaud Briat, Tatyana Timiryasova, Jennelle Francis
Publikováno v:
Gene therapy
Gene Therapy
Gene Therapy, 2009, 16 (10), pp.1223-1233. ⟨10.1038/gt.2009.74⟩
Gene Therapy
Gene Therapy, 2009, 16 (10), pp.1223-1233. ⟨10.1038/gt.2009.74⟩
Summary Survival following pancreatic cancer remains poor despite incremental advances in surgical and adjuvant therapy, and new strategies for treatment are needed. Oncolytic virotherapy is an attractive approach for cancer treatment. In this study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3591adf5c28a04fac692984b2e866ec4
http://europepmc.org/articles/PMC2762962
http://europepmc.org/articles/PMC2762962
Autor:
Weidong Zang, Yaohe Wang, Nicholas R. Lemoine, Xingbo Zhao, Hongyan Yang, Dongling Gao, Jinxia Yu, Ziming Dong, Vipul Bhakta, James R. Tysome, Kang-dong Liu, Yunhan Zhang, C.P. Chikkanna-Gowda, Rathi Gangeswaran, Claude Chelala, Ming Yuan, Guozhong Jiang, Pengju Wang, Fengyu Cao, Jennelle Francis
Publikováno v:
Journal of Clinical Investigation. 119:1604-1615
The changes in cancer cell surface molecules and intracellular signaling pathways during tumorigenesis make delivery of adenovirus-based cancer therapies inefficient. Here we have identified carcinoembryonic antigen- related cell adhesion molecule 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f88aa5b43f2ef1bab79cfd6945d27b0
https://doi.org/10.1172/jci37905
https://doi.org/10.1172/jci37905
Autor:
Gunnel Halldén, Nicholas R. Lemoine, Yaohe Wang, Brooks G, David H. Kirn, Ta-Chiang Liu, Jennelle Francis
Publikováno v:
Gene Therapy. 12:1333-1346
Replication-selective oncolytic adenoviruses hold promise, but novel mechanisms must be identified to maximize intratumoral virus persistence, spread and therapeutic transgene-carrying capacity while maintaining safety. One of the main approaches to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7b7cd5dc6c36263e32462d992c2d1cf
https://doi.org/10.1038/sj.gt.3302555
https://doi.org/10.1038/sj.gt.3302555
Autor:
Nicholas R. Lemoine, Shao-An Xue, Yaohe Wang, Jennelle Francis, Ming Yuan, Gunnel Halldén, Beverly E. Griffin
Publikováno v:
Cancer Research. 65:1523-1531
Given the growing number of tumor types recognizably associated with EBV infection, it is critically important that therapeutic strategies are developed to treat such tumors. Replication-selective oncolytic adenoviruses represent a promising new plat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ee7b9570b1a4e79d00cc0df1139429a
https://doi.org/10.1158/0008-5472.can-04-3113
https://doi.org/10.1158/0008-5472.can-04-3113
Autor:
Ta-Chiang Liu, Arthi Anand, Yaohe Wang, David H. Kirn, Nicholas R. Lemoine, Gabriel Brooks, Richard Hill, Gunnel Halldén, Jennelle Francis
Publikováno v:
Nature Biotechnology. 21:1328-1335
Oncolytic replication-selective adenoviruses constitute a rapidly growing therapeutic platform for cancer. However, the role of the host immune response and the E3 immunoregulatory genes of the human adenovirus were unknown until now. We identified f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9920db996282b622dd19eaebffcd81c5
https://doi.org/10.1038/nbt887
https://doi.org/10.1038/nbt887
Autor:
Gunnel Halldén, Ta-Chiang Liu, Jennelle Francis, Arthi Anand, Yaohe Wang, Lynda Hawkins, Richard Hill, David H. Kirn, Nicholas R. Lemoine
Publikováno v:
Molecular Therapy. 8(3):412-424
Oncolytic replication-selective adenoviruses constitute a rapidly expanding experimental approach to the treatment of cancer. However, due to the lack of an immunocompetent and replication-competent efficacy model, the role of the host immune respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::480376d8b40ffc1812fede62424e6666
Autor:
Yaohe Wang, Stephen Thorne, Joseph Hannock, Jennelle Francis, Tina Au, Tony Reid, Nick Lemoine, David Kirn, Gunnel Halldén
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 11(1)
Purpose: Replication-selective oncolytic adenoviruses hold promise for cancer treatment, but the predictive use of cell lines, dissociated tumor tissue, and animal models for efficacy against primary cancers are unclear. To further evaluate cytotoxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96aaf749be458ece0554da0b902f1b51
https://pubmed.ncbi.nlm.nih.gov/15671566
https://pubmed.ncbi.nlm.nih.gov/15671566
Autor:
Gunnel Halldén, Ghassan Alusi, Yaohe Wang, U. Bapat, Nicholas R. Lemoine, Jennelle Francis, E. Chisholm
Publikováno v:
Clinical Otolaryngology. 31:582-583
Objectives. To evaluate the oncolytic potential of a replication-selective mutant adenovirus (VAI-deleted adenovirus) in an established EBV-positive cancer cell line and to develop a new regime to enhance the potency of the virus by combination with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dca6af8ed0185af2e507467902fa543a
https://doi.org/10.1111/j.1365-2273.2006.01341_13.x
https://doi.org/10.1111/j.1365-2273.2006.01341_13.x
Autor:
Nicholas R. Lemoine, David H. Kirn, Gunnel Halldén, Jennelle Francis, Richard Hill, Yaohe Wang, Catherine Simpson
Publikováno v:
Molecular Therapy. 9:S374-S375
We recently developed a number of immunocompetent murine tumour models that enabled the evaluation of adenoviruses with classical E3 deletions, dl309 (E3B deleted (RIDa/RIDb complex and 14.7kD)) and dl704 (E3 gp19K deleted). The E3B genes protect inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4da0d3723aafc9218b2efafea4335803
https://doi.org/10.1016/j.ymthe.2004.06.952
https://doi.org/10.1016/j.ymthe.2004.06.952