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pro vyhledávání: '"Jennelle Durnett Richardson"'
Autor:
Martin H. Plawecki, Michael J Opperman, Jennelle Durnett Richardson, Jonathan Chastain, Christine Eckel, Brennan Schiller, Larrilyn L Grant
Publikováno v:
Medical Science Educator
Introduction There has been a move to a “flipped classroom” (FC) in medical education. The FC promotes active learning and utilizes independent preparation prior to in-class sessions. Few studies have evaluated the effectiveness of the FC approac
Publikováno v:
Journal of Endodontics. 27:620-623
Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter that is elevated in inflamed human dental pulp. Because GABA agonists are antihyperalgesic in other tissue, it is possible that GABA agonists have similar effects in dental pulp assumin
Autor:
Jennelle Durnett Richardson
Publikováno v:
The Journal of Pain. 1:2-14
Historically, the evidence for cannabinoids acting as analgesics has been mostly anecdotal. Recently, studies utilizing animal models have indicated that cannabinoids produce antinociception and antihyperalgesia by acting at peripheral, spinal, and s
Publikováno v:
Pain. 75:111-119
Central antinociceptive effects of cannabinoids have been well documented. However, relatively little is known about the peripheral effects of the cannabinoids on inflammation. In the present study, we evaluated the effects of peripherally administer
Publikováno v:
The Journal of Neuroscience. 14:4329-4337
The results of behavioral studies suggest that nitric oxide (NO) participates in certain spinal mechanisms that contribute to hyperalgesia. Additionally, previous studies indicate that the release of immunoreactive calcitonin gene-related peptide (iC
Publikováno v:
Brain Research. 646:135-139
Hindpaw injections of carrageenan (CARRA) decreased paw withdrawal latencies to radiant heat and increased hindpaw edema. At the peak of hyperalgesia, the content of immunoreactive guanosine 3′, 5′-cyclic monophosphate (i-cGMP) was increased, whi
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 302(3)
Since the initial observations that stimulation of sensory neurons produces vasodilation, plasma extravasation, and hypersensitivity, much progress has been made in understanding the etiology of neurogenic inflammation. Studies have focused largely o
Publikováno v:
European journal of pharmacology. 345(2)
Cannabinoids have been widely reported to produce antinociception in models such as tail flick and hot plate. However, their role in modulating thermal hyperalgesia is unknown. The potency of some drugs, such as the opioids, increases during hyperalg
Cannabinoids, such as Δ9-THC, are capable of inhibiting nociception, i.e., pain transmission, at least in part, by interacting with spinal Gi/Go-coupled cannabinoid receptors. What is not known, however, is the antinociceptive role ofendogenousspina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72290e8e26426c8845600d822fdcc115
https://europepmc.org/articles/PMC6793401/
https://europepmc.org/articles/PMC6793401/
Publikováno v:
European journal of pharmacology. 319(2-3)
Antinociceptive effects of cannabinoids are well documented. However, the physiological role of endogenous cannabinoids in nociception is unknown. We evaluated the effects of the cannabinoid receptor antagonist SR 141716A (N-piperidino-5-(4-chlorophe