Výsledky vyhledávání - "Jenneke Kloezeman"

Akademický článek

Locally-Delivered T-Cell-Derived Cellular Vehicles Efficiently Track and Deliver Adenovirus Delta24-RGD to Infiltrating Glioma

Autor: Rutger K. Balvers, Zineb Belcaid, Sanne K. van den Hengel, Jenneke Kloezeman, Jeroen de Vrij, Hiroaki Wakimoto, Rob C. Hoeben, Reno Debets, Sieger Leenstra, Clemens Dirven, Martine L.M. Lamfers

Publikováno v: Viruses, Vol 6, Iss 8, Pp 3080-3096 (2014)

Oncolytic adenoviral vectors are a promising alternative for the treatment of glioblastoma. Recent publications have demonstrated the advantages of shielding viral particles within cellular vehicles (CVs), which can be targeted towards the tumor micr

Externí odkaz: https://doaj.org/article/2668f9a73c0b4395a972d8b6dbf912a9

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Akademický článek

The in vivo therapeutic efficacy of the oncolytic adenovirus Delta24-RGD is mediated by tumor-specific immunity.

Autor: Anne Kleijn, Jenneke Kloezeman, Elike Treffers-Westerlaken, Giulia Fulci, Sieger Leenstra, Clemens Dirven, Reno Debets, Martine Lamfers

Publikováno v: PLoS ONE, Vol 9, Iss 5, p e97495 (2014)

The oncolytic adenovirus Delta24-RGD represents a new promising therapeutic agent for patients with a malignant glioma and is currently under investigation in clinical phase I/II trials. Earlier preclinical studies showed that Delta24-RGD is able to

Externí odkaz: https://doaj.org/article/158d9294c950469e912b1fb756c81cee

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Low-dose oncolytic adenovirus therapy overcomes tumor-induced immune suppression and sensitizes intracranial gliomas to anti-PD-1 therapy

Autor: Tessa Pierson, Zineb Belcaid, Edward van Beelen, Michael Lim, Martine L.M. Lamfers, Denis Routkevitch, Jenneke Kloezeman, Dimitrios Mathios, Mariëlle van der Kaaij, John Choi, Alicia van der Ploeg, Eftychia Stavrakaki, Cor A. Berrevoets, Stefan Sleijfer, Reno Debets, Clemens M F Dirven

Publikováno v: Neuro-Oncology Advances, 2(1), 1-12. Oxford University Press
Neuro-oncology Advances

BackgroundThe tumor-selective human adenovirus Delta24-RGD is currently under investigation in phase II clinical trials for patients with recurrent glioblastoma (GBM). To improve treatments for patients with GBM, we explored the potential of combinin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42838b79230b4d32d11641ce6d3c0f21
https://doi.org/10.1093/noajnl/vdaa011

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A Systematic Comparison Identifies an ATP-Based Viability Assay as Most Suitable Read-Out for Drug Screening in Glioma Stem-Like Cells

Autor: Martine L.M. Lamfers, M. Van Der Kaaij, Anne Kleijn, Sieger Leenstra, Clemens M F Dirven, Jenneke Kloezeman, Rutger K. Balvers

Publikováno v: Stem Cells International
Stem Cells International, Vol 2016 (2016)

Serum-free culture methods for patient-derived primary glioma cultures, selecting for glioma stem-like cells (GSCs), are becoming the gold standard in neurooncology research. These GSCs can be implemented in drug screens to detect patient-specific re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd37612a26d7f47e2df990fbcf48826e
https://doi.org/10.1155/2016/5623235

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Evolution of DNA repair defects during malignant progression of low-grade gliomas after temozolomide treatment

Publikováno v: Acta Neuropathologica, 129(4), 597-607. Springer-Verlag
Acta Neuropathologica, 129, 597-607
Acta Neuropathologica, 129(4), 597-607. Springer Verlag
van Thuijl, H F, Mazor, T, Johnson, BE, Fouse, S D, Aihara, K, Hong, C B, Malmstrom, A, Hallbeck, M, Heimans, J J, Kloezeman, J J, Stenmark-Askmalm, M, Lamfers, M L M, Saito, N, Aburatani, H, Mukasa, A, Berger, M S, Soderkvist, P, Taylor, B S, Molinaro, A M, Wesseling, P, Reijneveld, J C, Chang, S M, Ylstra, B & Costello, J F 2015, ' Evolution of DNA repair defects during malignant progression of low-grade gliomas after temozolomide treatment ', Acta Neuropathologica, vol. 129, no. 4, pp. 597-607 . https://doi.org/10.1007/s00401-015-1403-6
Acta neuropathologica, vol 129, iss 4
Acta neuropathologica, 129(4), 597-607. Springer Verlag
Acta Neuropathologica, 129(4), 597. Springer Verlag
Acta Neuropathologica, 129, 4, pp. 597-607

Contains fulltext : 155226.pdf (Publisher’s version ) (Closed access) Temozolomide (TMZ) increases the overall survival of patients with glioblastoma (GBM), but its role in the clinical management of diffuse low-grade gliomas (LGG) is still being d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da29b22ce3c0f46a49a1cc6e38119e78
https://doi.org/10.1007/s00401-015-1403-6

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In vitro screening of clinical drugs identifies sensitizers of oncolytic viral therapy in glioblastoma stem-like cells

Autor: Rutger K. Balvers, Sean E. Lawler, Michał Nowicki, Jenneke Kloezeman, Ennio Antonio Chiocca, B G van den Hoogen, W van den Bossche, Andreas Kremer, Martine L.M. Lamfers, Sieger Leenstra, L. M. E. Berghauser Pont, Clemens M F Dirven, Hiroaki Wakimoto

Publikováno v: Gene Therapy, 22(12), 947-959. Nature Publishing Group

Oncolytic viruses (OV) have broad potential as an adjuvant for the treatment of solid tumors. The present study addresses the feasibility of clinically applicable drugs to enhance the oncolytic potential of the OV Delta24-RGD in glioblastoma. In tota

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::843b03de1e747f67923b7afe78f4f19d
https://doi.org/10.1038/gt.2015.72

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DNA Methylation and Somatic Mutations Converge on the Cell Cycle and Define Similar Evolutionary Histories in Brain Tumors

Publikováno v: Cancer Cell, 28(3), 307-317. Cell Press
Cancer cell, vol 28, iss 3

SummaryThe evolutionary history of tumor cell populations can be reconstructed from patterns of genetic alterations. In contrast to stable genetic events, epigenetic states are reversible and sensitive to the microenvironment, prompting the question

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40ccae5a81373ee750cd2cfb86b4d1d1
https://hdl.handle.net/1765/85078

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The Sequence of Delta24-RGD and TMZ Administration in Malignant Glioma Affects the Role of CD8(+)T Cell Anti-tumor Activity

Autor: Chantal Burghoorn-Maas, Martine L.M. Lamfers, Suzan D. Pas, Reno Debets, Sieger Leenstra, Anne Kleijn, Wouter B.L. van den Bossche, Clemens M F Dirven, Jeroen de Vrij, Zineb Belcaid, Jenneke Kloezeman, Erik S. Haefner

Publikováno v: Molecular Therapy-Oncolytics, 5, 11-19. Cell Press
Molecular Therapy: Oncolytics, Vol 5, Iss C, Pp 11-19 (2017)

The conditionally replicating oncolytic adenovirus Delta24-RGD (Ad) is currently under investigation in clinical trials for glioblastoma, including in combination with temozolomide (TMZ), the standard chemotherapy for this tumor. Previously, we showe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b810104e6374f4d57ea81e8f5908083
https://pure.eur.nl/en/publications/4533f29a-5405-46a1-a03e-34fe09af80cd

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The Bcl-2 inhibitor Obatoclax overcomes resistance to histone deacetylase inhibitors SAHA and LBH589 as radiosensitizers in patient-derived glioblastoma stem-like cells

Autor: Jenneke Kloezeman, Peter J. van der Spek, Sigrid M. A. Swagemakers, Subramanian Venkatesan, Clemens M F Dirven, Jochem K H Spoor, Lotte M. E. Berghauser Pont, Sieger Leenstra, Martine L.M. Lamfers

Publikováno v: Genes & Cancer

Glioblastoma has shown resistance to histone deacetylase inhibitors (HDACi) as radiosensitizers in cultures with Bcl-XL over-expression. We study the efficacy of SAHA/RTx and LBH589/RTx when manipulating Bcl-2 family proteins using the Bcl- 2 inhibit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d315124750fc7d8db8671f929e177b90
https://doi.org/10.18632/genesandcancer.42

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