Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jenna Richter"'
The WNT target SP5 negatively regulates WNT transcriptional programs in human pluripotent stem cells
Autor:
Ian J. Huggins, Tomas Bos, Olivia Gaylord, Christina Jessen, Brianna Lonquich, Angeline Puranen, Jenna Richter, Charlotte Rossdam, David Brafman, Terry Gaasterland, Karl Willert
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
WNT/β-catenin signaling is an essential regulator of many developmental processes. Here, the authors provide evidence that activation of the WNT in human pluripotent stem cells leads to expression WNT target gene SP5, which then acts to diminish exp
Externí odkaz:
https://doaj.org/article/7264afb5c1c3408ea9b76760065ca559
Autor:
Stephanie Grainger, Jenna Richter, Raquel Espín Palazón, Claire Pouget, Brianna Lonquich, Sara Wirth, Kathrin Sabine Grassme, Wiebke Herzog, Matthew R. Swift, Brant M. Weinstein, David Traver, Karl Willert
Publikováno v:
Cell Reports, Vol 17, Iss 6, Pp 1595-1606 (2016)
All mature blood cell types in the adult animal arise from hematopoietic stem and progenitor cells (HSPCs). However, the developmental cues regulating HSPC ontogeny are incompletely understood. In particular, the details surrounding a requirement for
Externí odkaz:
https://doaj.org/article/41708572565849e5a7e7ccb860acec85
Autor:
Nathan Kumar, Jenna Richter, Josh Cutts, Kevin T Bush, Cleber Trujillo, Sanjay K Nigam, Terry Gaasterland, David Brafman, Karl Willert
Publikováno v:
eLife, Vol 4 (2015)
The field of tissue engineering entered a new era with the development of human pluripotent stem cells (hPSCs), which are capable of unlimited expansion whilst retaining the potential to differentiate into all mature cell populations. However, these
Externí odkaz:
https://doaj.org/article/27f020729a6c4f04b5fe3dcd04b64c52
Autor:
Chet Huan Oon, Jenna Richter, David Gonzalez, Jordan Setayesh, Jacob M. Wozniak, Brianna Lonquich, Stephanie Grainger, David Traver, Marvic Carrillo-Terrazas, Caramai N. Kamei, Rocio Barahona, Jack Houston, Nicole Nguyen, Karl Willert, Iain A. Drummond
Publikováno v:
Nature cell biology
Wnt signalling drives a plethora of processes in development, homeostasis, and disease; however, the role and mechanism of individual ligand/receptor (Wnt/Frizzled, Fzd) interactions in specific biological processes remain poorly understood. Wnt9a is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1f783914bd670eb6fa07f576f9935ac
https://pubmed.ncbi.nlm.nih.gov/31110287
https://pubmed.ncbi.nlm.nih.gov/31110287
Autor:
Nam-Phuong Nguyen, Brianna Lonquich, David Traver, Barahona R, Setayesh J, Jack Houston, Chet Huan Oon, Iain A. Drummond, David Gonzalez, Marvic Carrillo-Terrazas, Jenna Richter, Stephanie Grainger, Jacob M. Wozniak, Karl Willert, Caramai N. Kamei
SummaryThe mechanisms of Wnt-Frizzled (Fzd) signaling selectivity and their biological implications remain unclear. We demonstrate for the first time that the epidermal growth factor receptor (EGFR) is required as a co-factor for Wnt signaling. Using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acf8500323f3a6641a4ccbf2a8ae3faa
Autor:
David Traver, Karl Willert, Elizabeth Ng, Andrew G. Elefanty, Edouard G. Stanley, Jenna Richter
Publikováno v:
Genes; Volume 9; Issue 2; Pages: 66
Genes
Genes
Hematopoietic stem cells (HSCs) differentiate into all cell types of the blood and can be used therapeutically to treat hematopoietic cancers and disorders. Despite decades of research, it is not yet possible to derive therapy-grade HSCs from pluripo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdadebb773fddee30dc367e21d19a075
The WNT target SP5 negatively regulates WNT transcriptional programs in human pluripotent stem cells
Autor:
Karl Willert, Tomas Bos, Christina Jessen, Ian J. Huggins, Angeline Puranen, Brianna Lonquich, David A. Brafman, Terry Gaasterland, Charlotte Rossdam, Jenna Richter, Olivia Gaylord
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Nature communications, vol 8, iss 1
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Nature communications, vol 8, iss 1
The WNT/β-catenin signaling pathway is a prominent player in many developmental processes, including gastrulation, anterior–posterior axis specification, organ and tissue development, and homeostasis. Here, we use human pluripotent stem cells (hPS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679314a79da915c20548407d5bb5fed6
http://europepmc.org/articles/PMC5647328
http://europepmc.org/articles/PMC5647328
Publikováno v:
Critical reviews in biochemistry and molecular biology, vol 52, iss 4
Hematopoietic stem cells (HSCs) can self renew and differentiate into all cell types of the blood. This is therapeutically important as HSC transplants can provide a curative effect for blood cancers and disorders. The process by which HSCs develop h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bfc3768f8696be4c2a9abd2920cea38
https://pubmed.ncbi.nlm.nih.gov/28508727
https://pubmed.ncbi.nlm.nih.gov/28508727
Autor:
Matthew R. Swift, Raquel Espin Palazon, Stephanie Grainger, Wiebke Herzog, Jenna Richter, Karl Willert, Sara A. Wirth, Brant M. Weinstein, Claire Pouget, Brianna Lonquich, David Traver, Kathrin S. Grassme
Publikováno v:
Cell reports, vol 17, iss 6
Cell reports
Cell Reports, Vol 17, Iss 6, Pp 1595-1606 (2016)
Cell reports
Cell Reports, Vol 17, Iss 6, Pp 1595-1606 (2016)
Summary All mature blood cell types in the adult animal arise from hematopoietic stem and progenitor cells (HSPCs). However, the developmental cues regulating HSPC ontogeny are incompletely understood. In particular, the details surrounding a require
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81eeebbe116e84f3affba063d70763e4
https://escholarship.org/uc/item/8sc654bf
https://escholarship.org/uc/item/8sc654bf