Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Jenna McLaren"'
Autor:
Yuxiang Dong, Yogesh Sonawane, Steven P. Maher, Anne-Marie Zeeman, Victor Chaumeau, Amélie Vantaux, Caitlin A. Cooper, Francis C. K. Chiu, Eileen Ryan, Jenna McLaren, Gong Chen, Sergio Wittlin, Benoît Witkowski, François Nosten, Kamaraj Sriraghavan, Dennis E. Kyle, Clemens H. M. Kocken, Susan A. Charman, Jonathan L. Vennerstrom
Publikováno v:
ACS Omega. 7:12401-12411
The catechol derivative RC-12 (WR 27653) (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e050e54dd84232f0b99386c14fc1b10a
https://doi.org/10.1021/acsomega.2c01099
https://doi.org/10.1021/acsomega.2c01099
Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439
Autor:
Nada Abla, Yuxiang Dong, Daniel Hunziker, Jörg J. Möhrle, André Alker, Jenna McLaren, Hugues Matile, Jonathan L. Vennerstrom, Kasiram Katneni, Christian Scheurer, Susan A. Charman, Sriraghavan Kamaraj, Scott Blundell, Xiaofang Wang, Sergio Wittlin, Lin Zhou, Francis C. K. Chiu, David M. Shackleford, Qingjie Zhao
Publikováno v:
ACS Infect Dis
OZ439 is a potent synthetic ozonide evaluated for the treatment of uncomplicated malaria. The metabolite profile of OZ439 was characterized in vitro using human liver microsomes combined with LC/MS-MS, chemical derivatization, and metabolite synthesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3be4a450af4d05a8bd5e3a45a546d15
https://doi.org/10.1021/acsinfecdis.1c00225
https://doi.org/10.1021/acsinfecdis.1c00225
Autor:
Pradipsinh K. Rathod, Margaret A. Phillips, Michael J. Palmer, Sreekanth Kokkonda, Farah El Mazouni, John H. White, David Waterson, Iñigo Angulo-Barturen, María Belén Jiménez-Díaz, Maria Santos Martinez-Martinez, Helena Barker, Leticia Huertas-Valentin, Jenna McLaren, Santiago Ferrer, Jeremy N. Burrows, Shatrughan P Shahi, Karen L. White, Maria Jose Lafuente-Monasterio, Dave Matthews, Gong Chen, Francis C. K. Chiu, David M. Shackleford, Elly Crighton, Kasiram Katneni, Xiaoyi Deng, Sergio Wittlin, Diana R. Tomchick, Susan A. Charman, Rajesh Chittimalla
Publikováno v:
J Med Chem
Malaria puts at risk nearly half the world's population and causes high mortality in sub-Saharan Africa, while drug resistance threatens current therapies. The pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase (DHODH) is a validated target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9c8bca2acecd67955624d5564e79816
https://doi.org/10.1021/acs.jmedchem.0c00311
https://doi.org/10.1021/acs.jmedchem.0c00311
Autor:
Simon Campbell, Karen L. White, Susann H. Krake, Gong Chen, Eileen Ryan, Jenna McLaren, Paul Willis, Pablo David G. Martinez, Luiz C. Dias, Susan A. Charman
Publikováno v:
European Journal of Medicinal Chemistry. 126:929-936
Phenotypic HTS campaigns with a blood stage malaria assay have been used to discover novel chemotypes for malaria treatment with potential alternative mechanisms of action compared to existing agents. N1-(5-(3-Chloro-4-fluorophenyl)furan-2-yl)-N3,N3-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be1d01a0557ae9b17c0c988452064a8
https://doi.org/10.1016/j.ejmech.2016.12.024
https://doi.org/10.1016/j.ejmech.2016.12.024