Výsledky vyhledávání - "Jenna M. McCracken"

Francisella tularensis Modulates a Distinct Subset of Regulatory Factors and Sustains Mitochondrial Integrity to Impair Human Neutrophil Apoptosis

Autor: Jenna M. McCracken, Ramona L. McCaffrey, Lauren C. Kinkead, Lee-Ann H. Allen

Publikováno v: Journal of Innate Immunity. 8:299-313

Tularemia is a disease characterized by profound neutrophil accumulation and tissue destruction. The causative organism, Francisella tularensis, is a facultative intracellular bacterium that replicates in neutrophil cytosol, inhibits caspase activati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ea1ca93c425246746a6b3b8b6d2a9f40
https://doi.org/10.1159/000443882

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Regulation of Human Neutrophil Apoptosis and Lifespan in Health and Disease

Autor: Jenna M. McCracken, Lee-Ann H. Allen

Publikováno v: Journal of Cell Death
Journal of Cell Death, Vol 2014, Iss 7, Pp 15-23 (2014)
Japanese Clinical Medicine, Vol 7 (2014)

Neutrophils (also called polymorphonuclear leukocytes, PMNs) are the most abundant white blood cells in humans and play a central role in innate host defense. Another distinguishing feature of PMNs is their short lifespan. Specifically, these cells s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7354e2f4f890836e72c00b5d09b7257c
http://europepmc.org/articles/PMC4167320

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Natural IgM Mediates Complement-Dependent Uptake of Francisella tularensis by Human Neutrophils via Complement Receptors 1 and 3 in Nonimmune Serum

Autor: Justin W. Kaufman, Jenna M. McCracken, Matthew E. Long, Justin T. Schwartz, Lee-Ann H. Allen, Jason H. Barker

Publikováno v: The Journal of Immunology. 189:3064-3077

A fundamental step in the life cycle of Francisella tularensis is bacterial entry into host cells. F. tularensis activates complement, and recent data suggest that the classical pathway is required for complement factor C3 deposition on the bacterial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d823eed225f47b369c21384e93eb73
https://doi.org/10.4049/jimmunol.1200816

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Francisella tularensis Alters Human Neutrophil Gene Expression: Insights into the Molecular Basis of Delayed Neutrophil Apoptosis

Autor: Frank R. DeLeo, Jenna M. McCracken, Lee-Ann H. Allen, Sarmistha Bandyopadhyay, Justin T. Schwartz, Adeline R. Whitney, Scott D. Kobayashi

Publikováno v: Journal of Innate Immunity. 5:124-136

We demonstrated recently that Francisella tularensis profoundly impairs human neutrophil apoptosis, but how this is achieved is largely unknown. Herein we used human oligonucleotide microarrays to test the hypothesis that changes in neutrophil gene e

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https://doi.org/10.1159/000342430

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Francisella tularensis Modulates a Distinct Subset of Regulatory Factors and Sustains Mitochondrial Integrity to Impair Human Neutrophil Apoptosis

Autor: Jenna M, McCracken, Lauren C, Kinkead, Ramona L, McCaffrey, Lee-Ann H, Allen

Publikováno v: Journal of innate immunity. 8(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6e50ba25cda54eabea63ecf89fe6c351
https://pubmed.ncbi.nlm.nih.gov/26906922

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Bacterial lipoproteins and other factors released byFrancisella tularensismodulate human neutrophil lifespan: Effects of aTLR1SNP on apoptosis inhibition

Autor: David S. Weiss, Laura C. Whitmore, Justin W. Kaufman, Lee-Ann H. Allen, Lauren C. Kinkead, Bradley D. Jones, Joshua R. Fletcher, Jason H. Barker, Jenna M. McCracken, Brandi B. Ketelsen

Publikováno v: Cellular Microbiology

Francisella tularensis infects several cell types including neutrophils, and aberrant neutrophil accumulation contributes to tissue destruction during tularaemia. We demonstrated previously that F. tularensis strains Schu S4 and live vaccine strain m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15b5d6055a4dcc06bb03af573f8eeadd
https://doi.org/10.1111/cmi.12795

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Francisella tularensis inhibits the intrinsic and extrinsic pathways to delay constitutive apoptosis and prolong human neutrophil lifespan

Autor: Drew C. Fayram, Justin T. Schwartz, Justin W. Kaufman, Jason H. Barker, Jenna M. McCracken, Lee-Ann H. Allen

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 188(7)

Francisella tularensis is a facultative intracellular bacterium that infects many cell types, including neutrophils. We demonstrated previously that F. tularensis inhibits NADPH oxidase assembly and activity and then escapes the phagosome to the cyto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e274b0fd40712b0969b51435ae7922e
https://pubmed.ncbi.nlm.nih.gov/22357630

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EccA1, a Component of the Mycobacterium marinum ESX-1 Protein Virulence Factor Secretion Pathway, Regulates Mycolic Acid Lipid Synthesis

Autor: David A. Ball, Eric J. Brown, Brigitte Y. Watkins, Jenna M. McCracken, Shilpa A. Joshi, Nina Aggarwal, Fredric Carlsson, Kassidy K. Huynh, Mei G. Sun

Publikováno v: Chemistry & Biology. (3):372-380

Summary Pathogenic mycobacteria, which cause multiple diseases including tuberculosis, secrete factors essential for disease via the ESX-1 protein export system and are partially protected from host defenses by their lipid-rich cell envelopes. These

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