Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Jenna M. Frame"'
Autor:
Kathleen E. McGrath, Jenna M. Frame, Katherine H. Fegan, James R. Bowen, Simon J. Conway, Seana C. Catherman, Paul D. Kingsley, Anne D. Koniski, James Palis
Publikováno v:
Cell Reports, Vol 11, Iss 12, Pp 1892-1904 (2015)
Hematopoietic potential arises in mammalian embryos before adult-repopulating hematopoietic stem cells (HSCs). At embryonic day 9.5 (E9.5), we show the first murine definitive erythro-myeloid progenitors (EMPs) have an immunophenotype distinct from p
Externí odkaz:
https://doaj.org/article/269ef6228cb94fd289fb02d1e72d7407
Autor:
Rebecca Soto, Kryn Stankunas, Mariam Hachimi, Jenna M. Frame, Edroaldo Lummertz da Rocha, George Q. Daley, Trista E. North, Gabriel A. Yette, Mohamad Ali Toufic Najia
Publikováno v:
Stem Cell Reports
Summary Across species, hematopoietic stem and progenitor cells (HSPCs) arise during embryogenesis from a specialized arterial population, termed hemogenic endothelium. Here, we describe a mechanistic role for the epigenetic regulator, Enhancer of ze
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02d3aaf78238603db93619fb670f9674
https://doi.org/10.1016/j.stemcr.2021.05.014
https://doi.org/10.1016/j.stemcr.2021.05.014
Autor:
Eleanor Meader, Paul J. Wrighton, Isaac Oderberg, Mindy Leder, Morgan Walcheck, Timothy Long, Eleanor Quenzer, Mariam Hachimi, Jenna M. Frame, Wolfram Goessling, Trista E. North
Publikováno v:
Blood. 140:8570-8571
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f039c363bdc5877569a2b86638ff91c9
https://doi.org/10.1182/blood-2022-170136
https://doi.org/10.1182/blood-2022-170136
Autor:
Jenna M. Frame, Trista E. North
Publikováno v:
Dev Cell
Hematopoietic stem and progenitor cells (HSPCs) arise during embryonic development and are essential for sustaining the blood and immune systems throughout life. Tight regulation of HSPC numbers is critical for hematopoietic homeostasis. Here, we ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28eeba298b509be551637fafed2c9a1e
https://doi.org/10.1016/j.devcel.2021.02.014
https://doi.org/10.1016/j.devcel.2021.02.014
Autor:
Shuai Li, Trista E. North, Kwok-Kin Wong, Patrick Cahan, Linda T. Vo, Ashlee J. Conway, Douglas A. Lauffenburger, Jessica Barragan, Melissa A. Kinney, James J. Collins, Jenna M. Frame, George Q. Daley
Publikováno v:
Nat Biotechnol
A major challenge for stem cell engineering is achieving a holistic understanding of the molecular networks and biological processes governing cell differentiation. To address this challenge, we describe a computational approach that combines gene ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::543d8fcdcd59b0b24e5293cf8364afdd
https://europepmc.org/articles/PMC7235931/
https://europepmc.org/articles/PMC7235931/
Publikováno v:
Seminars in Immunology. 27:379-387
The paradigm that all blood cells are derived from hematopoietic stem cells (HSCs) has been challenged by two findings. First, there are tissue-resident hematopoietic cells, including subsets of macrophages that are not replenished by adult HSCs, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7bbdf4ae8b2556f14cf4fd02b537c5a
https://doi.org/10.1016/j.smim.2016.03.013
https://doi.org/10.1016/j.smim.2016.03.013
Autor:
Alena Yermalovich, Jenna M. Frame, Mariam Hachimi, Michael A. Morse, George Q. Daley, Brianna Hilton, Thorsten M. Schlaeger, Patricia Sousa, Yosra Zhang, Daniel S. Pearson, Vanessa Lundin, Jihan K. Osborne, Areum Han, Trista E. North, Yu Chung Huang, Vivian Morris, Ran Jing, Pheobe Hunter, John Atwater, Caroline Kubaczka
Publikováno v:
Blood. 136:3-3
Erythropoiesis is an intricate process by which lineage-committed erythroid progenitors become mature red blood cells. Reticulocytes are terminal-staged, immature red blood cells with residual RNA after enucleation. In the absence of pathology, retic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35e5d0fc026c1a362057244060d3c3ea
https://doi.org/10.1182/blood-2020-142757
https://doi.org/10.1182/blood-2020-142757
Autor:
Timothy Long, Caroline Kubaczka, Ran Jing, Rebecca Soto, Virginie Esain, Trista E. North, Jenna M. Frame, George Q. Daley, Mariam Hachimi, Wolfram Goessling, Arkadi Shwartz
Publikováno v:
Developmental Cell. 55:133-149.e6
Summary Embryonic hematopoietic stem and progenitor cells (HSPCs) robustly proliferate while maintaining multilineage potential in vivo; however, an incomplete understanding of spatiotemporal cues governing their generation has impeded robust product
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abee040f70d02aab0872fa8c64d72bd6
https://doi.org/10.1016/j.devcel.2020.07.015
https://doi.org/10.1016/j.devcel.2020.07.015
Hematopoietic stem cells (HSCs) reside at the apex of the hematopoietic hierarchy, giving rise to each of the blood lineages found throughout the lifetime of the organism. Since the genetic programs regulating HSC development are highly conserved bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d04edba1adf48c66e59e1c71d4d5cd1
https://doi.org/10.1016/bs.mcb.2016.08.004
https://doi.org/10.1016/bs.mcb.2016.08.004
Autor:
Jenna M. Frame, Paul J. Wrighton, George Q. Daley, Trista E. North, Rebecca Soto, Linda T. Vo, Mariam Hachimi, Wolfram Goessling, Edroaldo Lummertz da Rocha
Publikováno v:
Blood. 134:3710-3710
Understanding how hematopoietic stem cells (HSCs) are specified from mesodermal precursors is essential to the goal of generating patient-specific HSCs capable of multi-potent long-term function. HSCs are born from hemogenic endothelium in select art
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8c04d48a6660e9fafe1cb5ea5118191
https://doi.org/10.1182/blood-2019-131464
https://doi.org/10.1182/blood-2019-131464