Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Jenna L. Jewell"'
Publikováno v:
JCI Insight, Vol 8, Iss 13 (2023)
The mammalian target of rapamycin complex 1 (mTORC1) senses multiple upstream stimuli to orchestrate anabolic and catabolic events that regulate cell growth and metabolism. Hyperactivation of mTORC1 signaling is observed in multiple human diseases; t
Externí odkaz:
https://doaj.org/article/b0e8b281061e4634ab98ed5a5893bba5
Autor:
Chase H. Melick, Jenna L. Jewell
Publikováno v:
Genes, Vol 11, Iss 9, p 989 (2020)
The mammalian target of rapamycin (mTOR) is an evolutionary conserved Ser/Thr protein kinase that senses multiple upstream stimuli to control cell growth, metabolism, and autophagy. mTOR is the catalytic subunit of mTOR complex 1 (mTORC1). A signific
Externí odkaz:
https://doaj.org/article/ab419d58807241f6abae113c75db571e
Autor:
Shihai Zhang, Huanyu Wang, Chase H Melick, Mi-Hyeon Jeong, Adna Curukovic, Shweta Tiwary, Tshering D Lama-Sherpa, Delong Meng, Kelly A Servage, Nicholas G James, Jenna L Jewell
Publikováno v:
PLoS Genetics, Vol 17, Iss 10, p e1009832 (2021)
The mammalian target of rapamycin complex 1 (mTORC1) senses multiple stimuli to regulate anabolic and catabolic processes. mTORC1 is typically hyperactivated in multiple human diseases such as cancer and type 2 diabetes. Extensive research has focuse
Externí odkaz:
https://doaj.org/article/358b3427813548ef951b4b856085d782
Publikováno v:
Biochemical Society Transactions. 51:655-664
The Rag GTPases are an evolutionarily conserved family that play a crucial role in amino acid sensing by the mammalian target of rapamycin complex 1 (mTORC1). mTORC1 is often referred to as the master regulator of cell growth. mTORC1 hyperactivation
Autor:
Josephine W. Thinwa, Zhongju Zou, Emily Parks, Salwa Sebti, Kelvin Hui, Yongjie Wei, Vibha Singh, Greg Urquhart, Jenna L. Jewell, Julie K. Pfeiffer, Beth Levine, Tiffany A. Reese, Michael U. Shiloh
Virophagy, the selective autophagosomal engulfment and degradation of viral components, is crucial for antiviral immunity. However, the mechanisms leading to viral antigen recognition and autophagy induction remain poorly understood. Here, we identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a14f446e39a5beb9926a75ec48ecd15
https://doi.org/10.1101/2022.09.20.508746
https://doi.org/10.1101/2022.09.20.508746
Autor:
Delong Meng, Qianmei Yang, Mi-Hyeon Jeong, Adna Curukovic, Shweta Tiwary, Chase H. Melick, Tshering D. Lama-Sherpa, Huanyu Wang, Mariela Huerta-Rosario, Greg Urquhart, Lauren G. Zacharias, Cheryl Lewis, Ralph J. DeBerardinis, Jenna L. Jewell
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Mammalian target of rapamycin complex 1 (mTORC1) senses amino acids to control cell growth, metabolism, and autophagy. Some amino acids signal to mTORC1 through the Rag GTPase, whereas glutamine and asparagine activate mTORC1 through a Rag GTPase-ind
Publikováno v:
J Biol Chem
mTOR complex 1 (mTORC1) senses nutrients to mediate anabolic processes within the cell. Exactly how mTORC1 promotes cell growth remains unclear. Here, we identified a novel mTORC1-interacting protein called protein kinase A anchoring protein 8L (AKAP
Autor:
Jenna L. Jewell, Chase H. Melick
Publikováno v:
Biochemical Journal
The mammalian target of rapamycin (mTOR) is an evolutionarily conserved Ser/Thr kinase that comprises two complexes, termed mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). mTORC1 phosphorylates S6K1 at Thr 389, whereas mTORC2 phosphorylates AKT
Autor:
Jenna L. Jewell, Delong Meng, Qianmei Yang, Rishika Navlani, Anderson R. Frank, Chase H. Melick, Huanyu Wang
Publikováno v:
Journal of Biological Chemistry. 295:2890-2899
Nutrient sensing by cells is crucial, and when this sensing mechanism is disturbed, human disease can occur. mTOR complex 1 (mTORC1) senses amino acids to control cell growth, metabolism, and autophagy. Leucine, arginine, and methionine signal to mTO
Autor:
Shweta Tiwary, Tshering D. Lama-Sherpa, Delong Meng, Shihai Zhang, Jenna L. Jewell, Nicholas G. James, Mi Hyeon Jeong, Chase H. Melick, Adna Curukovic, Huanyu Wang, Kelly A. Servage
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 17, Iss 10, p e1009832 (2021)
PLoS Genetics, Vol 17, Iss 10, p e1009832 (2021)
The mammalian target of rapamycin complex 1 (mTORC1) senses multiple stimuli to regulate anabolic and catabolic processes. mTORC1 is typically hyperactivated in multiple human diseases such as cancer and type 2 diabetes. Extensive research has focuse