Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Jenna L. Betters"'
Autor:
Gwynneth Thomas, Jenna L. Betters, Caleb C. Lord, Amanda L. Brown, Stephanie Marshall, Daniel Ferguson, Janet Sawyer, Matthew A. Davis, John T. Melchior, Lawrence C. Blume, Allyn C. Howlett, Pavlina T. Ivanova, Stephen B. Milne, David S. Myers, Irina Mrak, Vera Leber, Christoph Heier, Ulrike Taschler, Jacqueline L. Blankman, Benjamin F. Cravatt, Richard G. Lee, Rosanne M. Crooke, Mark J. Graham, Robert Zimmermann, H. Alex Brown, J. Mark Brown
Publikováno v:
Cell Reports, Vol 5, Iss 2, Pp 508-520 (2013)
The serine hydrolase α/β hydrolase domain 6 (ABHD6) has recently been implicated as a key lipase for the endocannabinoid 2-arachidonylglycerol (2-AG) in the brain. However, the biochemical and physiological function for ABHD6 outside of the central
Externí odkaz:
https://doaj.org/article/458ed2401c5a458c8f277853db671abf
Autor:
Feng Guo, Yinyan Ma, Anil K.G. Kadegowda, Jenna L. Betters, Ping Xie, George Liu, Xiuli Liu, Hongming Miao, Juanjuan Ou, Xiong Su, Zhenlin Zheng, Bingzhong Xue, Hang Shi, Liqing Yu
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 8, Pp 2109-2120 (2013)
Triglyceride (TG) accumulation in hepatocytes (hepatic steatosis) preludes the development of advanced nonalcoholic fatty liver diseases (NAFLDs) such as steatohepatitis, fibrosis, and cirrhosis. Mutations in human Comparative Gene Identification-58
Externí odkaz:
https://doaj.org/article/c612d0766f394fa39435d54e04dc42a4
Autor:
Jorge M. Caviglia, Jenna L. Betters, Dianne-Helerie Dapito, Caleb C. Lord, Sean Sullivan, Streamson Chua, Terry Yin, Anna Sekowski, Haiyan Mu, Lawrence Shapiro, J. Mark Brown, Dawn L. Brasaemle
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 11, Pp 2032-2042 (2011)
Adipose triglyceride lipase (ATGL) catalyzes the first step of triacylglycerol hydrolysis in adipocytes. Abhydrolase domain 5 (ABHD5) increases ATGL activity by an unknown mechanism. Prior studies have suggested that the expression of ABHD5 is limiti
Externí odkaz:
https://doaj.org/article/b63b3cdc7a4c4a2d99379e8b3caeb489
Autor:
Lin Jia, Yinyan Ma, Shunxing Rong, Jenna L. Betters, Ping Xie, Soonkyu Chung, Nanping Wang, Weiqing Tang, Liqing Yu
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 11, Pp 3135-3144 (2010)
Niemann-Pick C1-Like 1 (NPC1L1) mediates intestinal absorption of dietary and biliary cholesterol. Ezetimibe, by inhibiting NPC1L1 function, is widely used to treat hypercholesterolemia in humans. Interestingly, ezetimibe treatment appears to attenua
Externí odkaz:
https://doaj.org/article/a69c908d5d254de2aee222581724fc82
Autor:
J. Mark Brown, Jenna L. Betters, Caleb Lord, Yinyan Ma, Xianlin Han, Kui Yang, Heather M. Alger, John Melchior, Janet Sawyer, Ramesh Shah, Martha D. Wilson, Xiuli Liu, Mark J. Graham, Richard Lee, Rosanne Crooke, Gerald I. Shulman, Bingzhong Xue, Hang Shi, Liqing Yu
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 11, Pp 3306-3315 (2010)
Mutations of Comparative Gene Identification-58 (CGI-58) in humans cause triglyceride (TG) accumulation in multiple tissues. Mice genetically lacking CGI-58 die shortly after birth due to a skin barrier defect. To study the role of CGI-58 in integrat
Externí odkaz:
https://doaj.org/article/a3b91154d3f44901ab305189eaa5c386
Autor:
Martina Schweiger, Chase K Neumann, Justin D. Lathia, Russell Watts, Rudolf Zechner, Richard G. Lee, Guenter Haemmerle, Caleb C. Lord, J. Mark Brown, Rosanne M. Crooke, Jenna L. Betters, Amy C. Burrows, Takuya F. Sakaguchi, Anthony D. Gromovsky, Jessica Sacks, Gwynneth Thomas, Stephanie M. Marshall, Amanda L. Brown, Richard Lehner, Mark J. Graham, Rebecca C. Schugar, Daniel Ferguson
Publikováno v:
Cell Reports, Vol 16, Iss 4, Pp 939-949 (2016)
SummaryAdipose triglyceride lipase (ATGL) and comparative gene identification 58 (CGI-58) are critical regulators of triacylglycerol (TAG) turnover. CGI-58 is thought to regulate TAG mobilization by stimulating the enzymatic activity of ATGL. However
Autor:
J. Mark Brown, David S. Myers, Amanda L. Brown, Lawrence C. Blume, John T. Melchior, Stephanie M. Marshall, Mark J. Graham, H. Alex Brown, Benjamin F. Cravatt, Ulrike Taschler, Daniel Ferguson, Robert Zimmermann, Janet K. Sawyer, Jenna L. Betters, Stephen B. Milne, Rosanne M. Crooke, Caleb C. Lord, Vera Leber, Matthew A. Davis, Gwynneth Thomas, Allyn C. Howlett, Irina Mrak, Richard G. Lee, Pavlina T. Ivanova, Christoph Heier, Jacqueline L. Blankman
Publikováno v:
Cell Reports, Vol 5, Iss 2, Pp 508-520 (2013)
Summary The serine hydrolase α/β hydrolase domain 6 (ABHD6) has recently been implicated as a key lipase for the endocannabinoid 2-arachidonylglycerol (2-AG) in the brain. However, the biochemical and physiological function for ABHD6 outside of the
Autor:
John S. Parks, Michael B. Fessler, Soonkyu Chung, Rosanne M. Crooke, Stephen B. Milne, David S. Myers, Mingxia Liu, J. Mark Brown, Richard G. Lee, Matthew A. Davis, Caleb C. Lord, H. Alex Brown, Jennifer H. Madenspacher, Mark J. Graham, Jenna L. Betters, Dawn L. Brasaemle, Pavlina T. Ivanova, Gwynneth Thomas
Publikováno v:
Diabetes
Mutations of comparative gene identification 58 (CGI-58) in humans cause Chanarin-Dorfman syndrome, a rare autosomal recessive disease in which excess triacylglycerol (TAG) accumulates in multiple tissues. CGI-58 recently has been ascribed two distin
Publikováno v:
Annual Review of Physiology. 73:239-259
Increased blood cholesterol is an independent risk factor for atherosclerotic cardiovascular disease. Cholesterol homeostasis in the body is controlled mainly by endogenous synthesis, intestinal absorption, and hepatic excretion. Niemann-Pick C1-Like
Autor:
Nanping Wang, Jenna L. Betters, Yinyan Ma, Ping Xie, Liqing Yu, Lin Jia, Shunxing Rong, Weiqing Tang, Soonkyu Chung
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 11, Pp 3135-3144 (2010)
Niemann-Pick C1-Like 1 (NPC1L1) mediates intestinal absorption of dietary and biliary cholesterol. Ezetimibe, by inhibiting NPC1L1 function, is widely used to treat hypercholesterolemia in humans. Interestingly, ezetimibe treatment appears to attenua