Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jenna K. Rimel"'
Autor:
Jacob Bassett, Jenna K. Rimel, Shrabani Basu, Pratik Basnet, Jie Luo, Krysta L. Engel, Michael Nagel, Alexander Woyciehowsky, Christopher C. Ebmeier, Craig D. Kaplan, Dylan J. Taatjes, Jeffrey A. Ranish
Publikováno v:
The Journal of biological chemistry. 298(10)
TFIIH is an evolutionarily conserved complex that plays central roles in both RNA polymerase II (pol II) transcription and DNA repair. As an integral component of the pol II preinitiation complex, TFIIH regulates pol II enzyme activity in numerous wa
Autor:
Yang Eric Guo, Brian J. Abraham, Tim-Michael Decker, Dylan J. Taatjes, Jenna K. Rimel, Phillip A. Sharp, Tong Ihn Lee, Charli B. Fant, John C. Manteiga, Krishna Shrinivas, Lena K. Afeyan, Benjamin R. Sabari, Richard A. Young, Jan-Hendrik Spille, Jonathan E. Henninger, Alessandra Dall’Agnese, Alicia V. Zamudio, Nancy M. Hannett, Ann Boija, Ibrahim I Cisse
Publikováno v:
Nature
The synthesis of pre-mRNA by RNA polymerase II (Pol II) involves the formation of a transcription initiation complex, and a transition to an elongation complex1–4. The large subunit of Pol II contains an intrinsically disordered C-terminal domain t
Autor:
Goran Malojčić, Martine Brault, Ines H. Kaltheuner, Lewis C. Cantley, Patrick Deroy, Heeyoun Bunch, Shanhu Hu, Janet Iwasa, Robin D. Dowell, Michael J. Bradley, Christian Clavette, Limei Tao, Peter W. White, Matthias Geyer, Zachary C. Poss, William M. Old, Zachary L. Maas, Shraddha Nayak, Tim-Michael Decker, Christopher C. Ebmeier, Benjamin Erickson, Leah J. Damon, David Bentley, Jenna K. Rimel, Tomer M. Yaron, Jason J. Marineau, Jared L. Johnson, Kristin B. Hamman, Dylan J. Taatjes
Publikováno v:
Genes Dev
CDK7 associates with the 10-subunit TFIIH complex and regulates transcription by phosphorylating the C-terminal domain (CTD) of RNA polymerase II (RNAPII). Few additional CDK7 substrates are known. Here, using the covalent inhibitor SY-351 and quanti
Autor:
Steven Hahn, Olivia Luyties, Susan E. Tsutakawa, Jill O. Fuss, Chi Lin Tsai, James Fishburn, Jenna K. Rimel, Eric J. Tomko, Eric A. Galburt, Dylan J. Taatjes
Publikováno v:
J Mol Biol
Journal of molecular biology, vol 433, iss 14
Journal of molecular biology, vol 433, iss 14
The general transcription factor TFIIH contains three ATP-dependent catalytic activities. TFIIH functions in nucleotide excision repair primarily as a DNA helicase and in Pol II transcription initiation as a dsDNA translocase and protein kinase. Duri
Autor:
Jonathan D. Rubin, Jenna K. Rimel, Charli B. Fant, Zachary L. Maas, Dylan J. Taatjes, Meagan N. Esbin, Michael T. Marr, John Moir, Cecilia B. Levandowski, Kapil Gupta, Andrew Sawyer, Olivia Luyties, Robin D. Dowell, Imre Berger
Publikováno v:
Fant, C B, Levandowski, C B, Gupta, K, Maas, Z L, Moir, J, Rubin, J D, Sawyer, A, Esbin, M N, Rimel, J K, Luyties, O, Marr, M T, Berger, I, Dowell, R D & Taatjes, D J 2020, ' TFIID Enables RNA Polymerase II Promoter-Proximal Pausing ', Molecular Cell, vol. 78, no. 4, pp. 785-793.e8 . https://doi.org/10.1016/j.molcel.2020.03.008
Mol Cell
Mol Cell
Summary RNA polymerase II (RNAPII) transcription is governed by the pre-initiation complex (PIC), which contains TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, RNAPII, and Mediator. After initiation, RNAPII enzymes pause after transcribing less than 100 b
Autor:
Yang Eric, Guo, John C, Manteiga, Jonathan E, Henninger, Benjamin R, Sabari, Alessandra, Dall'Agnese, Nancy M, Hannett, Jan-Hendrik, Spille, Lena K, Afeyan, Alicia V, Zamudio, Krishna, Shrinivas, Brian J, Abraham, Ann, Boija, Tim-Michael, Decker, Jenna K, Rimel, Charli B, Fant, Tong Ihn, Lee, Ibrahim I, Cisse, Phillip A, Sharp, Dylan J, Taatjes, Richard A, Young
Publikováno v:
Nature. 572(7770)
The synthesis of pre-mRNA by RNA polymerase II (Pol II) involves the formation of a transcription initiation complex, and a transition to an elongation complex
Autor:
Tong Ihn Lee, John C. Manteiga, Alicia V. Zamudio, Charli B. Fant, Richard A. Young, Dylan J. Taatjes, Jurian Schuijers, Ann Boija, Nancy M. Hannett, Lena K. Afeyan, Benjamin R. Sabari, Eliot L. Coffey, Alessandra Dall’Agnese, Jenna K. Rimel, Isaac A. Klein, Charles H. Li, Krishna Shrinivas, Yang Eric Guo, Brian J. Abraham
Publikováno v:
PMC
Gene expression is controlled by transcription factors (TFs) that consist of DNA-binding domains (DBDs) and activation domains (ADs). The DBDs have been well characterized, but little is known about the mechanisms by which ADs effect gene activation.
Autor:
Jenna K. Rimel, Dylan J. Taatjes
Publikováno v:
Protein Science : A Publication of the Protein Society
TFIIH is a 10‐subunit complex that regulates RNA polymerase II (pol II) transcription but also serves other important biological roles. Although much remains unknown about TFIIH function in eukaryotic cells, much progress has been made even in just