Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Jenna Hoersten"'
Autor:
Felix Lansing, Liliya Mukhametzyanova, Teresa Rojo-Romanos, Kentaro Iwasawa, Masaki Kimura, Maciej Paszkowski-Rogacz, Janet Karpinski, Tobias Grass, Jan Sonntag, Paul Martin Schneider, Ceren Günes, Jenna Hoersten, Lukas Theo Schmitt, Natalia Rodriguez-Muela, Ralf Knöfler, Takanori Takebe, Frank Buchholz
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Correction of disease-causing large genomic inversions remains challenging. Here, the authors developed a dual designer-recombinase system (RecF8) that efficiently corrects a 140 kb inversion frequently found in patients with severe Hemophilia A.
Externí odkaz:
https://doaj.org/article/8d46d2035aed42e78c73c8d76348317f
Autor:
Milica Jelicic, Lukas Theo Schmitt, Maciej Paszkowski-Rogacz, Angelika Walder, Nadja Schubert, Jenna Hoersten, Duran Sürün, Frank Buchholz
Publikováno v:
Nucleic Acids Research.
Tyrosine-type site-specific recombinases (Y-SSRs) are versatile tools for genome engineering due to their ability to mediate excision, integration, inversion and exchange of genomic DNA with single nucleotide precision. The ever-increasing need for s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d407f57466e8e50f8c8648d25b1f16e4
https://doi.org/10.1093/nar/gkad366
https://doi.org/10.1093/nar/gkad366
Autor:
Jenna Hoersten, Gloria Ruiz-Gómez, Felix Lansing, Teresa Rojo-Romanos, Lukas Theo Schmitt, Jan Sonntag, M Teresa Pisabarro, Frank Buchholz
Publikováno v:
Nucleic Acids Research
Tyrosine site-specific recombinases (SSRs) represent a versatile genome editing tool with considerable therapeutic potential. Recent developments to engineer and evolve SSRs into heterotetramers to improve target site flexibility signified a critical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::834fb4ecb1aa0978c82962a59d1a9ffe
https://pubmed.ncbi.nlm.nih.gov/34951450
https://pubmed.ncbi.nlm.nih.gov/34951450
Publikováno v:
BIOspektrum. 27:139-141
Recent advances in nuclease-based genome editing allow for the correction of many point-mutations causing diseases. However, correcting genetic alterations caused by larger chromosomal rearrangements remain challenging with this approach. Designer-re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93b1996442185ba0e5c2e8e77b3ea595
https://doi.org/10.1007/s12268-021-1549-9
https://doi.org/10.1007/s12268-021-1549-9