Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Jenna H Newman"'
Autor:
Sharad Goyal, Howard L Kaufman, Andrew Zloza, Ann W Silk, Vineet Gupta, Shang-Jui Wang, Bruce G Haffty, Nicole R LeBoeuf, Sachin R Jhawar, Jose A Guevara-Patino, Timothy M Kuzel, Jochen Reiser, Aditya Thandoni, Praveen K Bommareddy, Jenna H Newman, Amanda L Marzo, Preston Daniels, Devora Schiff, Darrion Mitchell, Christopher Simmons, Ahmed Lasfar, Eileena F Giurini
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 7 (2023)
Background Immunotherapies are becoming front-line treatments for many advanced cancers, and combinations of two or more therapies are beginning to be investigated. Based on their individual antitumor capabilities, we sought to determine whether comb
Externí odkaz:
https://doaj.org/article/aa466472bc1745428fedfc56b28b3f77
Autor:
John P. Finnigan, Jenna H. Newman, Yury Patskovsky, Larysa Patskovska, Andrew S. Ishizuka, Geoffrey M. Lynn, Robert A. Seder, Michelle Krogsgaard, Nina Bhardwaj
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract T cell receptors (TCR) are pivotal in mediating tumour cell cytolysis via recognition of mutation-derived tumour neoantigens (neoAgs) presented by major histocompatibility class-I (MHC-I). Understanding the factors governing the emergence of
Externí odkaz:
https://doaj.org/article/c618911c78714f43801b9d080ea8aa73
Autor:
Mark N. Stein, Jyoti Malhotra, Rohinton S. Tarapore, Usha Malhotra, Ann W. Silk, Nancy Chan, Lorna Rodriguez, Joseph Aisner, Robert D. Aiken, Tina Mayer, Bruce G. Haffty, Jenna H. Newman, Salvatore M. Aspromonte, Praveen K. Bommareddy, Ricardo Estupinian, Charles B. Chesson, Evita T. Sadimin, Shengguo Li, Daniel J. Medina, Tracie Saunders, Melissa Frankel, Aparna Kareddula, Sherrie Damare, Elayne Wesolowsky, Christian Gabel, Wafik S. El-Deiry, Varun V. Prabhu, Joshua E. Allen, Martin Stogniew, Wolfgang Oster, Joseph R. Bertino, Steven K. Libutti, Janice M. Mehnert, Andrew Zloza
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-9 (2019)
Abstract Background ONC201 is a small molecule antagonist of DRD2, a G protein-coupled receptor overexpressed in several malignancies, that has prolonged antitumor efficacy and immunomodulatory properties in preclinical models. The first-in-human tri
Externí odkaz:
https://doaj.org/article/cc2e3e6b70b34104941a2588a1bfa557
Autor:
Matthew D. Park, Ivan Reyes-Torres, Jessica LeBerichel, Pauline Hamon, Nelson M. LaMarche, Samarth Hegde, Meriem Belabed, Leanna Troncoso, John A. Grout, Assaf Magen, Etienne Humblin, Achuth Nair, Martina Molgora, Jinchao Hou, Jenna H. Newman, Adam M. Farkas, Andrew M. Leader, Travis Dawson, Darwin D’Souza, Steven Hamel, Alfonso Rodriguez Sanchez-Paulete, Barbara Maier, Nina Bhardwaj, Jerome C. Martin, Alice O. Kamphorst, Ephraim Kenigsberg, Maria Casanova-Acebes, Amir Horowitz, Brian D. Brown, Lucas Ferrari De Andrade, Marco Colonna, Thomas U. Marron, Miriam Merad
Publikováno v:
Nature Immunology. 24:792-801
Autor:
Marco Rossi, Salvatore M. Aspromonte, Frederick J. Kohlhapp, Jenna H. Newman, Alex Lemenze, Russell J. Pepe, Samuel M. DeFina, Nora L. Herzog, Robert Donnelly, Timothy M. Kuzel, Jochen Reiser, Jose A. Guevara-Patino, Andrew Zloza
Publikováno v:
Diagnostics, Vol 12, Iss 4, p 958 (2022)
Through a multitude of studies, the gut microbiota has been recognized as a significant influencer of both homeostasis and pathophysiology. Certain microbial taxa can even affect treatments such as cancer immunotherapies, including the immune checkpo
Externí odkaz:
https://doaj.org/article/fb4d6e6cb67047918d92eaad3c631ea6
Autor:
Frederick J. Kohlhapp, Erica J. Huelsmann, Andrew T. Lacek, Jason M. Schenkel, Jevgenijs Lusciks, Joseph R. Broucek, Josef W. Goldufsky, Tasha Hughes, Janet P. Zayas, Hubert Dolubizno, Ryan T. Sowell, Regina Kühner, Sarah Burd, John C. Kubasiak, Arman Nabatiyan, Sh’Rae Marshall, Praveen K. Bommareddy, Shengguo Li, Jenna H. Newman, Claude E. Monken, Sasha H. Shafikhani, Amanda L. Marzo, Jose A. Guevara-Patino, Ahmed Lasfar, Paul G. Thomas, Edmund C. Lattime, Howard L. Kaufman, Andrew Zloza
Publikováno v:
Cell Reports, Vol 17, Iss 4, Pp 957-965 (2016)
In light of increased cancer prevalence and cancer-specific deaths in patients with infections, we investigated whether infections alter anti-tumor immune responses. We report that acute influenza infection of the lung promotes distal melanoma growth
Externí odkaz:
https://doaj.org/article/21c3de3968b44525b8ba15963e57feea
Autor:
Joseph R. Broucek, Eileena F. Giurini, Nora L. Herzog, Lisa K. Denzin, Gabriel Guevara-Aleman, C. Brent Chesson, Ricardo Estupinian, Marco Rossi, Mary J. Fidler, Raquel E. Redondo, Jai S. Rudra, Joyce Paras, Jochen Reiser, Amanda L. Marzo, Jyoti Malhotra, Shang Jui Wang, Emily S. Ruiz, Stuti Buddhadev, Howard L. Kaufman, Saeed Tarabichi, Sachin R. Jhawar, Frederick J. Kohlhapp, Daniel J. Medina, Mones M. Aboelatta, David Rotter, Shengguo Li, Leonard Y. Lee, Vineet Gupta, John Langenfeld, Ann W. Silk, Russell J. Pepe, Kajal Gupta, Timothy M. Kuzel, Jason M. Schenkel, Derek B. Sant'Angelo, Abdulkareem Abed, Jenna H. Newman, Michael J. Lee, Praveen K. Bommareddy, Salvatore M. Aspromonte, Ahmed Lasfar, Eric A. Singer, Michael P. Kane, Christina Nowicki, Arnold B. Rabson, Andrew Zloza, Paul G. Thomas, Josef W. Goldufsky
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Immunotherapy has revolutionized cancer treatment, yielding unprecedented long-term responses and survival. However, a significant proportion of patients remain refractory, which correlates with the absence of immune-infiltrated (“hot
Autor:
Nina Bhardwaj, Jenna H. Newman
Publikováno v:
Trends Immunol
Currently, immunotherapy is not effective for all cancer patients, partly due to an inability to mount sufficient tumor-specific T cell responses. Here, we highlight a recent study by Lhuillier et al. demonstrating that radiation potentiates neoantig
Autor:
Amir Horowitz, Jenna H. Newman
Publikováno v:
Nat Rev Immunol
A preprint by Hasim et al. shows that tumour cell-derived PD1 can be acquired by natural killer cells through trogocytosis, which dampens their anti-tumour effector function.
Autor:
Praveen K. Bommareddy, Wafik S. El-Deiry, Tracie Saunders, Salvatore M. Aspromonte, Lorna Rodriguez, Rohinton Tarapore, Janice M. Mehnert, Steven K. Libutti, Nancy Chan, Ann W. Silk, Jenna H. Newman, Charles B. Chesson, Elayne Wesolowsky, Daniel J. Medina, Christian Gabel, Martin Stogniew, Shengguo Li, Joseph R. Bertino, Joshua E. Allen, Mark N. Stein, Evita Sadimin, Aparna Kareddula, Joseph Aisner, Sherrie Damare, Jyoti Malhotra, Wolfgang Oster, Varun V. Prabhu, Bruce G. Haffty, Andrew Zloza, Ricardo Estupinian, Tina M. Mayer, Melissa Frankel, Robert Aiken, Usha Malhotra
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-9 (2019)
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-9 (2019)
Background ONC201 is a small molecule antagonist of DRD2, a G protein-coupled receptor overexpressed in several malignancies, that has prolonged antitumor efficacy and immunomodulatory properties in preclinical models. The first-in-human trial of ONC