Screening antivirals with a mCherry-expressing recombinant bovine respiratory syncytial virus: a proof of concept using cyclopamine

Autor: Jenna Fix, Delphyne Descamps, Marie Galloux, Cécile Ferret, Edwige Bouguyon, Siamak Zohari, Katarina Näslund, Sara Hägglund, Ralf Altmeyer, Jean-François Valarcher, Sabine Riffault, Jean-François Eléouët

Publikováno v: Veterinary Research, Vol 54, Iss 1, Pp 1-7 (2023)

Abstract Bovine respiratory syncytial virus (BRSV) is a pathogenic pneumovirus and a major cause of acute respiratory infections in calves. Although different vaccines are available against BRSV, their efficiency remains limited, and no efficient and

Externí odkaz: https://doaj.org/article/57a2ce4153c94fe582863d7f7f2a2d79

RSV hijacks cellular protein phosphatase 1 to regulate M2-1 phosphorylation and viral transcription.

Autor: Charles-Adrien Richard, Vincent Rincheval, Safa Lassoued, Jenna Fix, Christophe Cardone, Camille Esneau, Sergei Nekhai, Marie Galloux, Marie-Anne Rameix-Welti, Christina Sizun, Jean-François Eléouët

Publikováno v: PLoS Pathogens, Vol 14, Iss 3, p e1006920 (2018)

Respiratory syncytial virus (RSV) RNA synthesis occurs in cytoplasmic inclusion bodies (IBs) in which all the components of the viral RNA polymerase are concentrated. In this work, we show that RSV P protein recruits the essential RSV transcription f

Externí odkaz: https://doaj.org/article/f5df6a5db0e04e3b8b75242071b90e5a

Nucleoprotein nanostructures combined with adjuvants adapted to the neonatal immune context: a candidate mucosal RSV vaccine.

Autor: Aude Remot, Xavier Roux, Catherine Dubuquoy, Jenna Fix, Stephan Bouet, Mohammed Moudjou, Jean-François Eléouët, Sabine Riffault, Agnès Petit-Camurdan

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e37722 (2012)

BackgroundThe human respiratory syncytial virus (hRSV) is the leading cause of severe bronchiolitis in infants worldwide. The most severe RSV diseases occur between 2 and 6 months-of-age, so pediatric vaccination will have to be started within the fi

Externí odkaz: https://doaj.org/article/e8b59c5f1336419d9c4e58df6e4c0a5b

Characterization of the Interaction Domains between the Phosphoprotein and the Nucleoprotein of Human Metapneumovirus

Autor: Jean-François Eléouët, Monika Bajorek, Luis Checa Ruano, Marie Galloux, Jenna Fix, Charles-Adrien Richard, Hortense Decool, Olivier Sperandio, Irina Gutsche, Benjamin Bardiaux

Publikováno v: J Virol
Journal of Virology
Journal of Virology, 2022, 96 (2), pp.e0090921. ⟨10.1128/JVI.00909-21⟩

Human metapneumovirus (HMPV) causes severe respiratory diseases in young children. The HMPV RNA genome is encapsidated by the viral nucleoprotein (N), forming an RNA-N complex (N(Nuc)), which serves as the template for genome replication and mRNA tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f7efcc80720167008066e4d77c332fd
https://europepmc.org/articles/PMC8791268/

Depletion of TAX1BP1 amplifies innate immune responses during respiratory syncytial virus infection

Autor: Marie Galloux, Lorène Gonnin, Delphyne Descamps, Jean-François Eléouët, Carole Drajac, Quentin Marquant, Vincent Pietralunga, Armando Morais Ventura, Frédéric Tangy, Andressa Peres de Oliveira, Pierre-Olivier Vidalain, Sarah Madrières, Hidekatsu Iha, Edwige Bouguyon, Jenna Fix

Publikováno v: Journal of Virology
Journal of Virology, American Society for Microbiology, In press, ⟨10.1128/JVI.00912-21⟩
Journal of Virology, 2021, 95 (22), pp.e0091221. ⟨10.1128/JVI.00912-21⟩
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
J Virol

Respiratory syncytial virus (RSV) is the main cause of acute respiratory infections in young children, and also has a major impact in the elderly and immunocompromised people. In the absence of vaccine or efficient treatment, a better understanding o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83661d14e511a3f25e6cf1e4caa97b62
https://hal.inrae.fr/hal-03341825