Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation

Autor: Karin E. J. Rödström, Alexander Cloake, Janina Sörmann, Agnese Baronina, Kathryn H. M. Smith, Ashley C. W. Pike, Jackie Ang, Peter Proks, Marcus Schewe, Ingelise Holland-Kaye, Simon R. Bushell, Jenna Elliott, Els Pardon, Thomas Baukrowitz, Raymond J. Owens, Simon Newstead, Jan Steyaert, Elisabeth P. Carpenter, Stephen J. Tucker

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Abstract Potassium channels of the Two-Pore Domain (K2P) subfamily, KCNK1-KCNK18, play crucial roles in controlling the electrical activity of many different cell types and represent attractive therapeutic targets. However, the identification of high

Externí odkaz: https://doaj.org/article/9ac3923cca8e4d1e92ffe481cfd471bf

A functional family of fluorescent nucleotide analogues to investigate actin dynamics and energetics

Autor: Jenna Elliott, Jessica Colombo, Pekka Lappalainen, Konstantin Kogan, Alphée Michelot, Tommi Kotila, Audrey Guillotin, Adrien Antkowiak

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-020-20827-4⟩
Nature Communications, Nature Publishing Group, 2021, 12, pp.548. ⟨10.1038/s41467-020-20827-4⟩
Nature Communications, 2021, 12 (1), ⟨10.1038/s41467-020-20827-4⟩
Nature Communications, 2021, 12, pp.548. ⟨10.1038/s41467-020-20827-4⟩

Actin polymerization provides force for vital processes of the eukaryotic cell, but our understanding of actin dynamics and energetics remains limited due to the lack of high-quality probes. Most current probes affect dynamics of actin or its interac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6dc536806899363eef32858a0c0e224
https://doaj.org/article/887eda43f8084479b43243044a31eee3