Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment

Autor: Jie Li, Christopher R. Chin, Hsia-Yuan Ying, Cem Meydan, Matthew R. Teater, Min Xia, Pedro Farinha, Katsuyoshi Takata, Chi-Shuen Chu, Yiyue Jiang, Jenna Eagles, Verena Passerini, Zhanyun Tang, Martin A. Rivas, Oliver Weigert, Trevor J. Pugh, Amy Chadburn, Christian Steidl, David W. Scott, Robert G. Roeder, Christopher E. Mason, Roberta Zappasodi, Wendy Béguelin, Ari M. Melnick

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)

Abstract Despite regulating overlapping gene enhancers and pathways, CREBBP and KMT2D mutations recurrently co-occur in germinal center (GC) B cell-derived lymphomas, suggesting potential oncogenic cooperation. Herein, we report that combined haploin

Externí odkaz: https://doaj.org/article/a274f96f577b412184a054e29a28c213

Integrated analysis of cell-free DNA for the early detection of cancer in people with Li-Fraumeni Syndrome

Autor: Derek Wong, Ping Luo, Leslie Oldfield, Haifan Gong, Ledia Brunga, Ron Rabinowicz, Vallijah Subasri, Clarissa Chan, Tiana Downs, Kirsten M Farncombe, Beatrice Luu, Maia Norman, Jenna Eagles, Stephenie Pederson, Johanna Wellum, Arnavaz Danesh, Stephenie Prokopec, Eric Zhao, Nadia Znassi, Bernard Lam, Kayla Marsh, Yogi Sundaravadanam, Dax Torti, David Malkin, Raymond H Kim, Trevor J Pugh

SummaryDespite advances in cancer therapeutics, early detection is often the best prognostic indicator for survival (1). People with Li-Fraumeni syndrome harbor a germline pathogenic variant in the tumor suppressor geneTP53(2) and face a near 100% li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8069e2b3a2a11e5649e840964c3cee9a
https://doi.org/10.1101/2022.10.07.22280848

Personalized circulating tumor DNA analysis as a predictive biomarker in solid tumor patients treated with pembrolizumab

Autor: Philippe L. Bedard, Youstina Hanna, Jenna Eagles, Derek L. Clouthier, Alexey Aleshin, Himanshu Sethi, Iulia Cirlan, Marco A. J. Iafolla, Svetlana Shchegrova, Aaron R. Hansen, Scott C. Lien, Paul Billings, Trevor J. Pugh, Scott V. Bratman, Maggie C. Louie, Anna Spreafico, Wei Xu, S. Y. Cindy Yang, Albiruni Ryan Abdul Razak, Pamela S. Ohashi, Zhihui Liu, Stephanie Lheureux, Kayla Marsh, Lillian L. Siu, Bernhard Zimmermann, Dax Torti

Publikováno v: Nature Cancer. 1:873-881

Immune checkpoint blockade (ICB) provides clinical benefit to a subset of patients with cancer. However, existing biomarkers do not reliably predict treatment response across diverse cancer types. Limited data exist to show how serial circulating tum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6975c8528e9d0a74c47e83f9b4163d27
https://doi.org/10.1038/s43018-020-0096-5

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

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Zechen, Chong, Oliver, Drechsel, Lewis Jonathan Dursi, Roland, Eils, Shadrielle M, G Espiritu, Robert, S Fulton, Shengjie, Gao, Josep L, L Gelpi, Mark, B Gerstein, Santiago, Gonzalez, Ivo, G Gut, Faraz, Hach, Michael, C Heinold, Jonathan, Hinton, Taobo, Hu, Vincent, Huang, Huang, Yi, Barbara, Hutter, David, R Jones, Jongsun, Jung, Natalie, Jäger, Hyung-Lae, Kim, Kortine, Kleinheinz, Sushant, Kumar, Yogesh, Kumar, Christopher, M Lalansingh, Ivica, Letunic, Dimitri, Livitz, Eric, Z Ma, Yosef, E Maruvka, R Jay Mashl, Andrew, Menzies, Ana, Milovanovic, Morten Muhlig Nielsen, Stephan, Ossowski, Nagarajan, Paramasivam, Jakob Skou Pedersen, Marc, D Perry, Montserrat, Puiggròs, Keiran, M Raine, Esther, Rheinbay, Romina, Royo, S Cenk Sahinalp, Iman, Sarrafi, Matthias, Schlesner, Jared, T Simpson, Lucy, Stebbings, Miranda, D Stobbe, Jon, W Teague, Grace, Tiao, David, Torrents, Jeremiah, A Wala, Jiayin, Wang, Sebastian, M Waszak, Joachim, Weischenfeldt, Michael, C Wendl, Johannes, Werner, 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Charles, Short, Raunak, Shrestha, Suyash, S Shringarpure, Craig, Shriver, Shimin, Shuai, Nikos, Sidiropoulos, Reiner, Siebert, Anieta, M Sieuwerts, Lina, Sieverling, Sabina, Signoretti, Katarzyna, O Sikora, Michele, Simbolo, Ronald, Simon, Janae, V Simons, Peter, T Simpson, Samuel, Singer, Nasa, Sinnott-Armstrong, Payal, Sipahimalani, Tara, J Skelly, Marcel, Smid, Jaclyn, Smith, Karen, Smith-McCune, Nicholas, D Socci, Heidi, J Sofia, Matthew, G Soloway, Lei, Song, Anil, K Sood, Sharmila, Sothi, Christos, Sotiriou, Cameron, M Soulette, Paul, N Span, Paul, T Spellman, Sperandio, Nicola, Andrew, J Spillane, Oliver, Spiro, Jonathan, Spring, Johan, Staaf, Peter, F Stadler, Peter, Staib, Stefan, G Stark, Ólafur Andri Stefánsson, Oliver, Stegle, Lincoln, D Stein, Alasdair, Stenhouse, Stephan, Stilgenbauer, Michael, R Stratton, Jonathan, R Stretch, Henk, G Stunnenberg, Hong, Su, Xiaoping, Su, Ren, X Sun, Stephanie, Sungalee, Hana, Susak, Akihiro, Suzuki, Fred, Sweep, Monika, Szczepanowski, 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Publikováno v: Nature Communications, 11(1):4748. Nature Publishing Group
Nature communications, 11(1):4748. Nature Publishing Group
Nature communications, 11 (1
NATURE COMMUNICATIONS
Nature Communications, 11 (1)
Nature Communications, Vol 11, Iss 1, Pp 1-27 (2020)
Bailey, M H, Meyerson, W U, Dursi, L J, Wang, L B, Dong, G, Liang, W W, Weerasinghe, A, Li, S, Kelso, S, Akbani, R, Anur, P, Bailey, M H, Buchanan, A, Chiotti, K, Covington, K, Creason, A, Ding, L, Weischenfeldt, J, Brunak, S, Ding, L, Favero, F, MC3 Working Group, PCAWG novel somatic mutation calling methods working group & PCAWG Consortium 2020, ' Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples ', Nature Communications, vol. 11, no. 1, 4748 . https://doi.org/10.1038/s41467-020-18151-y
Bailey, Matthew H; Meyerson, William U; Dursi, Lewis Jonathan; Wang, Liang-Bo; Dong, Guanlan; Liang, Wen-Wei; Weerasinghe, Amila; Li, Shantao; Kelso, Sean; Saksena, Gordon; Ellrott, Kyle; Wendl, Michael C; Wheeler, David A; Getz, Gad; Simpson, Jared T; Gerstein, Mark B; Ding, Li (2020). Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples. Nature Communications, 11(1), p. 4748. Springer Nature 10.1038/s41467-020-18151-y
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Universidad de Barcelona
Nature Communications, 11, 1
Recercat. Dipósit de la Recerca de Catalunya
Digital.CSIC. Repositorio Institucional del CSIC
Nature Communications, 11
RUO: Repositorio Institucional de la Universidad de Oviedo
Universidad de Oviedo (UNIOVI)
Bailey, M H, Meyerson, W U, Dursi, L J, Wang, L B, Dong, G, Liang, W W, Weerasinghe, A, Li, S, Kelso, S, Akbani, R, Anur, P, Bailey, M H, Buchanan, A, Chiotti, K, Covington, K, Creason, A, Ding, L, MC3 Working Group, PCAWG novel somatic mutation calling methods working group & PCAWG Consortium 2020, ' Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples ', Nature Communications, vol. 11, no. 1, 4748 . https://doi.org/10.1038/s41467-020-18151-y
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)

MC3 Working Group: Rehan Akbani21, Pavana Anur22, Matthew H. Bailey1,2,3, Alex Buchanan9, Kami Chiotti9, Kyle Covington12,23, Allison Creason9, Li Ding1,2,3,20, Kyle Ellrott9, Yu Fan21, Steven Foltz1,2, Gad Getz8,14,15,16, Walker Hale12, David Haussl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79caf69aa08507159a37977adcb4937b
https://www.bib.irb.hr/1104730

Integration of Genomic and Transcriptomic Features in Pancreatic Cancer Reveals Increased Cell Cycle Progression in Metastases

Autor: Bradly G. Wouters, Sulaiman Nanji, Stefano Serra, George Zogopoulos, Joan Miguel Romero, Michelle Chan-Seng-Yue, Calvin Law, Dianne E. Chadwick, Paul M. Krzyzanowski, Lars G.T. Jorgensen, Jenna Eagles, Jessica Miller, Anna Dodd, David W. Hedley, Alyssa L. Smith, Amy Zhang, Grainne M. O'Kane, Xuemei Luo, Sandra Fischer, Sara Hafezi Bakhtiari, Sheng-Ben Liang, Julie M. Wilson, Gavin W. Wilson, Steven Gallinger, Ilinca Lungu, Mathieu Lemire, Jennifer J. Knox, Gloria M. Petersen, Talia Golan, Ayelet Borgida, Heather Armstrong, Ashton A. Connor, Sean P. Cleary, Prashant Bavi, Faiyaz Notta, Michael H.A. Roehrl, Faridah Mbabaali, Derin Caglar, Gun Ho Jang, John M. S. Bartlett, Michael A. Hollingsworth, Robert E. Denroche, Daniele Merico, Sarah P. Thayer

Publikováno v: SSRN Electronic Journal.

We integrated clinical, genomic and transcriptomic data from 217 primaries and 101 metastases from 289 patients to characterize progression of pancreatic ductal adenocarcinoma. Driver genes alterations, mutational and expression-based signatures were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::418394416d84907891f82f14f939fd82
https://doi.org/10.2139/ssrn.3188387