Regulation of Osteoclast Growth and Fusion by mTOR/raptor and mTOR/rictor/Akt

Autor: Kerstin Tiedemann, Damien Le Nihouannen, Jenna E. Fong, Osama Hussein, Jake E. Barralet, Svetlana V. Komarova

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 5 (2017)

Osteoclasts are giant bone cells formed by fusion from monocytes and uniquely capable of a complete destruction of mineralized tissues. Previously, we have demonstrated that in energy-rich environment not only osteoclast fusion index (the number of n

Externí odkaz: https://doaj.org/article/8ad46d5f4e494c1bb7ff86ca678fd560

The Movember Prostate Cancer Landscape Analysis: an assessment of unmet research needs

Autor: Sarah T.F. Hsiao, Charles J. Ryan, Beatrice S. Knudsen, Peter L. Choyke, Suneil Jain, Bertrand Tombal, Seanna L. Davidson, Jeremy L. Millar, Tony Crispino, Nadine Brew, Jenna E. Fong, Michelle M. Kouspou, Mark Buzza, Guido Jenster, Nicole Mittmann

Publikováno v: Nature Reviews Urology, 17(9), 499-512. Nature Publishing Group
Nature Reviews. Urology
Nature Reviews. Urology, Vol. 17, no. 9, p. 499-512 (2020)
Kouspou, M M, Fong, J E, Brew, N, Hsiao, S T F, Davidson, S L, Choyke, P L, Crispino, T, Jain, S, Jenster, G W, Knudsen, B S, Millar, J L, Mittmann, N, Ryan, C J, Tombal, B & Buzza, M 2020, ' The Movember Prostate Cancer Landscape Analysis: an assessment of unmet research needs ', Nature Reviews Urology, vol. 17, no. 9, pp. 499-512 . https://doi.org/10.1038/s41585-020-0349-1

Prostate cancer is a heterogeneous cancer with widely varying levels of morbidity and mortality. Approaches to prostate cancer screening, diagnosis, surveillance, treatment and management differ around the world. To identify the highest priority rese

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57ade12cf9147ff585a587bfdf8f5589
https://doi.org/10.1038/s41585-020-0349-1

Breast Cancer Metastases to Bone: Role of the Microenvironment

Autor: Svetlana V. Komarova, Jenna E. Fong

Publikováno v: Breast Cancer-Focusing Tumor Microenvironment, Stem cells and Metastasis

Bone is the preferred site for breast cancer metastasis, which leads to altered mineral metabolism, disruption of bone architecture, and considerable pain burden. Prior to homing to the bone, the primary breast tumour releases soluble factors that le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d10b546a756f80d8b5d08468a43f1ea5
https://doi.org/10.5772/21741

Abstract P6-07-01: CCN3 Impairs Osteoblasts and Stimulates Osteoclast Differentiation To Favor Breast Cancer Metastasis to Bone

Autor: Mark Clemons, Veronique Ouellet, Anna Mourskaia, Jenna E. Fong, Kerstin Tiedemann, D. Tran-Tanh, Pm. Siegel, Eitan Amir, Bernard Perbal, S. Komorova

Publikováno v: Cancer Research. 70:P6-07

Background: The mechanisms underlying the osteotropism of breast cancer are not fully understood. Breast cancer cell lines that aggressively metastasize to bone appear to have increased expression of CCN3 (Nov) compared to those that weakly metastasi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb3e1a96807a78699874fe0b3acd8705
https://doi.org/10.1158/0008-5472.sabcs10-p6-07-01