Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jenna Dotson"'
Autor:
Glen Stevens, Hilal Erdogan, Eleanor Pimentel, Jenna Dotson, Asa Stevens, David Shapiro-Ilan, Fatma Kaplan, Paul Schliekelman, Edwin Lewis
Publikováno v:
Biological Control. 181:105220
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5069f1584bc6e1c7c393c6d520b34535
https://doi.org/10.1016/j.biocontrol.2023.105220
https://doi.org/10.1016/j.biocontrol.2023.105220
Autor:
Laurent Salphati, Nicole Blaquiere, Cristina Lewis, Steven Do, Binqing Wei, Steven T. Staben, Aleksandr Kolesnikov, Alan G. Olivero, Erin K. Bradley, Jim Nonomiya, Lionel Rouge, Jenna Dotson, Jodie Pang, Vickie Tsui, John Lesnick, Richard Goldsmith, Timothy P. Heffron, Ping Wu, Jeremy Murray, Christian Wiesmann
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:897-901
Substructural class effects surrounding replacement of a 'cis' N-methyl aniline amide within potent and selective thienobenzoxepin PI3-kinase inhibitors are disclosed. While a simple aryl to alkyl switch was not tolerated due to differences in prefer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63e276c9ba5f322f7d0b934889b837f9
https://doi.org/10.1016/j.bmcl.2012.10.121
https://doi.org/10.1016/j.bmcl.2012.10.121
Autor:
Bing-Yan Zhu, Daniel J. Burdick, Cristina Lewis, Leslie Lee, Jodie Pang, Timothy P. Heffron, Lionel Rouge, Hoa Le, Jim Nonomiya, Michael Siu, Deepak Sampath, Christian Wiesmann, Alan G. Olivero, Laurent Salphati, Steven Do, Daniel P. Sutherlin, Ping Wu, Steve Sideris, Jeremy Murray, Steven T. Staben, Vickie Tsui, Richard Goldsmith, Wei Wei Prior, Jenna Dotson, John Lesnick
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:4054-4058
Starting from thienobenzopyran HTS hit 1, co-crystallization, molecular modeling and metabolic analysis were used to design potent and metabolically stable inhibitors of PI3-kinase. Compound 15 demonstrated PI3K pathway suppression in a mouse MCF7 xe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f3ae4dfd1334a411e6cc97f4dfb59ea
https://doi.org/10.1016/j.bmcl.2011.04.124
https://doi.org/10.1016/j.bmcl.2011.04.124
Autor:
Lori Friedman, Lionel Rouge, Daniel P. Sutherlin, Georgette Castanedo, Adrian Folkes, Nan Chi Wan, Wei Wei Prior, Shumei Wang, Emile Plise, Ping Wu, Seema R. Bhat, Cristina Lewis, Deepak Sampath, Jeremy Murray, Alan G. Olivero, Jim Nonomiya, Timothy P. Heffron, Leslie Lee, Laurent Salphati, Irina Chuckowree, Steven T. Staben, Vickie Tsui, Bing-Yan Zhu, Christian Weismann, Jenna Dotson, Jodie Pang, John Lesnick
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6048-6051
Starting from HTS hit 1a, X-ray co-crystallization and molecular modeling were used to design potent and selective inhibitors of PI3-kinase. Bioavailablity in this series was improved through careful modulation of physicochemical properties. Compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f5dfb15d68c0d5ace550e093eca7d77
https://doi.org/10.1016/j.bmcl.2010.08.067
https://doi.org/10.1016/j.bmcl.2010.08.067
Autor:
Shumei Wang, Susan Wong, Laurent Salphati, Simon Mathieu, John Lesnick, Deepak Sampath, Nan Chi Wan, Jodie Pang, Irina Chuckowree, Alan G. Olivero, Cristina Lewis, Daniel P. Sutherlin, Jim Nonomiya, Adrian Folkes, Zhigang Chang, Christian Wiesmann, Tim Heffron, Lori Friedman, Jenna Dotson, Richard Goldsmith, Georgette Castanedo, Wei Wei Prior, Steve Sideris, Leslie Lee, Vickie Tsui, Qingping Tian, Bing-Yan Zhu, Megan Berry
Publikováno v:
Journal of Medicinal Chemistry. 53:1086-1097
The PI3K/AKT/mTOR pathway has been shown to play an important role in cancer. Starting with compounds 1 and 2 (GDC-0941) as templates, (thienopyrimidin-2-yl)aminopyrimidines were discovered as potent inhibitors of PI3K or both PI3K and mTOR. Structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a01dbe4957dc3c1f294e6e22c73dcc85
https://doi.org/10.1021/jm901284w
https://doi.org/10.1021/jm901284w
Autor:
Laura Corson, Thomas Hunsaker, Yingqing Ran, Andrea G. Cochran, Elizabeth Blackwood, Hans-Willi Krell, Leslie Walker, Jun Li, Birong Zhang, Aihe Zhou, Jason Halladay, Thomas E. Rawson, Bing-Yan Zhu, Carter Fields, Brian Safina, Mark Ultsch, Matthias Rüth, Tracy Kleinheinz, Angela McNutt, Dan Burdick, Jun Liang, Jason Drummond, Petra Rüger, Christian Wiesmann, Bernhard Goller, Guy Georges, Gail Lewis Phillips, Anja Limberg, John Moffat, Jenna Dotson
Publikováno v:
Journal of Medicinal Chemistry. 51:4465-4475
Aurora kinase inhibitors have attracted a great deal of interest as a new class of antimitotic agents. We report a novel class of Aurora inhibitors based on a pentacyclic scaffold. A prototype pentacyclic inhibitor 32 (AKI-001) derived from two early
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6298eaa13aa6a279801fb4d948e210a7
https://doi.org/10.1021/jm800052b
https://doi.org/10.1021/jm800052b
Autor:
Kevin R Clark, Thomas R. Gadek, Martin E. Struble, James H. Bourell, Denise A. Ockey, Jenna Dotson, John T. Stults
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:37-44
A novel class of nonpeptide inhibitors of stromelysin (MMP-3) has been discovered with the use of mass spectrometry. The method relies on the development of structure–activity relationships by mass spectrometry (SAR by MS) and utilizes information
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b66b0c91c5bac46b85e9ceadce0c11c
https://doi.org/10.1016/j.bmc.2003.10.053
https://doi.org/10.1016/j.bmc.2003.10.053
Autor:
Vickie Tsui, Laurent Salphati, Binqing Wei, Linda Bao, Richard Goldsmith, Niel Pegg, Megan Berry, Wei Wei Prior, Bing-Yan Zhu, Jim Nonomiya, Shumei Wang, Ping Wu, Jeremy Murray, Timothy P. Heffron, Adrian Folks, Irina Chuckowree, Qingping Tian, Alan G. Olivero, Janet L. Gunzner, Cristina Lewis, Jodie Pang, Lionel Rouge, Nan Chi Wan, Simon Mathieu, Georgette Castanedo, Christian Wiesmann, Lori Friedman, John Lesnick, Daniel P. Sutherlin, Jenna Dotson, Deepak Sampath
Publikováno v:
Journal of medicinal chemistry. 54(21)
The discovery of 2 (GDC-0980), a class I PI3K and mTOR kinase inhibitor for oncology indications, is described. mTOR inhibition was added to the class I PI3K inhibitor 1 (GDC-0941) scaffold primarily through the substitution of the indazole in 1 for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92ddde0beea93ee1938d2e986322ae16
https://pubmed.ncbi.nlm.nih.gov/21981714
https://pubmed.ncbi.nlm.nih.gov/21981714
Autor:
Daniel P. Sutherlin, Linda Bao, Megan Berry, Georgette Castanedo, Irina Chuckowree, Jenna Dotson, Adrian Folks, Lori Friedman, Richard Goldsmith, Janet Gunzner, Timothy Heffron, John Lesnick, Cristina Lewis, Simon Mathieu, Jeremy Murray, Jim Nonomiya, Jodie Pang, Niel Pegg, Wei Wei Prior, Lionel Rouge
Publikováno v:
Journal of Medicinal Chemistry; Nov2011, Vol. 54 Issue 21, p7579-7587, 9p
Autor:
Thomas E. Rawson, Matthias Rüth, Elizabeth Blackwood, Dan Burdick, Laura Corson, Jenna Dotson, Jason Drummond, Carter Fields, Guy J. Georges, Bernhard Goller, Jason Halladay, Thomas Hunsaker, Tracy Kleinheinz, Hans-Willi Krell, Jun Li, Jun Liang, Anja Limberg, Angela McNutt, John Moffat, Gail Phillips
Publikováno v:
Journal of Medicinal Chemistry; Jul2008, Vol. 51 Issue 15, p4465-4475, 11p