Western Diet-Fed, Aortic-Banded Ossabaw Swine

Autor: T. Dylan Olver, PhD, Jenna C. Edwards, BS, Thomas J. Jurrissen, BS, Adam B. Veteto, MS, John L. Jones, MS, Chen Gao, BS, Christoph Rau, PhD, Chad M. Warren, MS, Paula J. Klutho, PhD, Linda Alex, PhD, Stephanie C. Ferreira-Nichols, BS, Jan R. Ivey, BS, Pamela K. Thorne, MS, Kerry S. McDonald, PhD, Maike Krenz, MD, Christopher P. Baines, PhD, R. John Solaro, PhD, Yibin Wang, PhD, David A. Ford, PhD, Timothy L. Domeier, PhD, Jaume Padilla, PhD, R. Scott Rector, PhD, Craig A. Emter, PhD

Publikováno v: JACC: Basic to Translational Science, Vol 4, Iss 3, Pp 404-421 (2019)

Summary: The development of new treatments for heart failure lack animal models that encompass the increasingly heterogeneous disease profile of this patient population. This report provides evidence supporting the hypothesis that Western Diet−fed,

Externí odkaz: https://doaj.org/article/234f0de86b414fc8be6239d78aedf7cf

The right ventricular transcriptome signature in Ossabaw swine with cardiometabolic heart failure: implications for the coronary vasculature

Autor: Bradley S. Fleenor, Laurel A. Grisanti, Shannon C Kelly, Craig A. Emter, T. Dylan Olver, An Ouyang, Christoph Rau, Jaume Padilla, R. Scott Rector, Yibin Wang, Jenna C. Edwards, Pamela K. Thorne, Timothy L. Domeier

Publikováno v: Physiol Genomics

Heart failure (HF) patients with deteriorating right ventricular (RV) structure and function have a nearly twofold increased risk of death compared with those without. Despite the well-established clinical risk, few studies have examined the molecula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dc9d5706d82dd236b31128496538e41
https://europepmc.org/articles/PMC7988741/

Endothelial dysfunction occurs independently of adipose tissue inflammation and insulin resistance in ovariectomized Yucatan miniature-swine

Autor: Gabriela S. Lin, Jaume Padilla, Jessica A. Hiemstra, Victoria J. Vieira-Potter, T. Dylan Olver, Michelle L. Gastecki, Jenna C. Edwards, Zachary I. Grunewald, Craig A. Emter, Rebecca J. Welly, Thomas J. Jurrissen, Nathan C. Winn

Publikováno v: Adipocyte. 7:35-44

In rodents, experimentally-induced ovarian hormone deficiency increases adiposity and adipose tissue (AT) inflammation, which is thought to contribute to insulin resistance and increased cardiovascular disease risk. However, whether this occurs in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40b6b94491542b99500d316f401cb500
https://doi.org/10.1080/21623945.2017.1405191

Western Diet-Fed, Aortic-Banded Ossabaw Swine: A Preclinical Model of Cardio-Metabolic Heart Failure

Autor: R. John Solaro, Chad M. Warren, Chen Gao, Timothy L. Domeier, Stephanie C. Ferreira-Nichols, Jan R. Ivey, Maike Krenz, Linda Alex, Jaume Padilla, John L. Jones, Yibin Wang, Thomas J. Jurrissen, Christoph Rau, R. Scott Rector, Christopher P. Baines, Jenna C. Edwards, Paula J. Klutho, T. Dylan Olver, David A. Ford, Kerry S. McDonald, Craig A. Emter, Adam B. Veteto, Pamela K. Thorne

Publikováno v: JACC. Basic to translational science, vol 4, iss 3
JACC: Basic to Translational Science
JACC: Basic to Translational Science, Vol 4, Iss 3, Pp 404-421 (2019)

Visual Abstract
Highlights • The combination of a Western-diet and aortic banding results in a cardio-metabolic heart failure phenotype in Ossabaw swine. • Ossabaw swine with cardio-metabolic heart failure display cardiac dysfunction at the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddbaeb8b6b97277796ad4183f62766a6
https://escholarship.org/uc/item/2pt6t1r5

Right Ventricular Hypertrophy is Associated with Increased MAPK8, Fibronectin, and Extracellular Matrix Regulatory Biomarker (MMP/TIMP) mRNA Levels in a Pre‐Clinical Swine Model of HFpEF

Autor: Jenna C. Edwards, Shannon C. Kelly, Craig A. Emter, Christoph Rau, Pamela K. Thorne, T. Dylan Olver, Timothy L. Domeier, Jaume Padilla, Yibin Wang, R. Scott Rector

Publikováno v: The FASEB Journal. 33

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd50e37b680c31435f43aa5fbdeca4a4
https://doi.org/10.1096/fasebj.2019.33.1_supplement.530.4