In situ analysis of neuronal injury and neuroinflammation during HIV-1 infection

Autor: Jenna B. Honeycutt, Angela Wahl, Jacob K. Files, Alexis F. League, Barkha J. Yadav-Samudrala, J. Victor Garcia, Sylvia Fitting

Publikováno v: Retrovirology, Vol 21, Iss 1, Pp 1-16 (2024)

Abstract Background Since the introduction of combination antiretroviral therapy (cART) the brain has become an important human immunodeficiency virus (HIV) reservoir due to the relatively low penetration of many drugs utilized in cART into the centr

Externí odkaz: https://doaj.org/article/d5ece5e4edd64dc59a5cd3a175ce3050

In Vivo Suppression of HIV Rebound by Didehydro-Cortistatin A, a 'Block-and-Lock' Strategy for HIV-1 Treatment

Autor: Mohammad Fallahi, Susana T. Valente, Christopher C. Nixon, Jenna B. Honeycutt, Perry Tsai, Cari F. Kessing, Lydie Trautmann, J. Victor Garcia, Guillaume Mousseau, Chuan Li, Hiroshi Takata, Phong T. Ho

Publikováno v: Cell Reports, Vol 21, Iss 3, Pp 600-611 (2017)

HIV-1 Tat activates viral transcription and limited Tat transactivation correlates with latency establishment. We postulated a “block-and-lock” functional cure approach based on properties of the Tat inhibitor didehydro-Cortistatin A (dCA). HIV-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::167bb69b313881856d617b6086ad4cb2
http://www.sciencedirect.com/science/article/pii/S2211124717313852

T cells establish and maintain CNS viral infection in HIV-infected humanized mice

Autor: Michael D. Swanson, Christopher S. Evans, Baolin Liao, Shayla L. Birath, Francesca Prince, Angela Wahl, William O. Thayer, Rachel A. Cleary, J. Victor Garcia, Joseph J. Eron, Christopher C. Nixon, Joann D. Kuruc, Oksana Zakharova, Patricia A. Sheridan, Jenna B. Honeycutt

The human brain is an important site of HIV replication and persistence during antiretroviral therapy (ART). Direct evaluation of HIV infection in the brains of otherwise healthy individuals is not feasible; therefore, we performed a large-scale stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::920d8a3e78f0e877da6d54417b9f6780

ART influences HIV persistence in the female reproductive tract and cervicovaginal secretions

Autor: Michael D. Swanson, Amy Richardson, Angela Wahl, Tomonori Nochi, Rikke Olesen, Julie M. Long, Martin Tolstrup, Martina Kovarova, Jenna B. Honeycutt, J. Victor Garcia, Morgan Chateau, Michael G. Hudgens, Lars Østergaard, Paul W. Denton

Publikováno v: Olesen, R, Swanson, M D, Kovarova, M, Nochi, T, Chateau, M, Honeycutt, J B, Long, J M, Denton, P W, Hudgens, M G, Richardson, A, Tolstrup, M, Østergaard, L J, Wahl, A & Garcia, J V 2016, ' ART influences HIV persistence in the female reproductive tract and cervicovaginal secretions ', Journal of Clinical Investigation . https://doi.org/10.1172/JCI64212

The recently completed HIV prevention trials network study 052 is a landmark collaboration demonstrating that HIV transmission in discordant couples can be dramatically reduced by treating the infected individual with antiretroviral therapy (ART). Ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a94964332ea998c6e59072d3fdfa3a9
https://pure.au.dk/portal/da/publications/art-influences-hiv-persistence-in-the-female-reproductive-tract-and-cervicovaginal-secretions(3aee42ff-96d5-4fd0-ae5d-35d3b9f314dc).html

Humanized mouse models for HIV-1 infection of the CNS

Autor: Patricia A. Sheridan, J. Victor Garcia, Glenn K. Matsushima, Jenna B. Honeycutt

Since the onset of the HIV epidemic, there has been a shift from a deadly diagnosis to the management of a chronic disease. This shift is the result of the development of highly effective drugs that are able to suppress viral replication for years. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d006065c32939bdc906747cc0ed160eb
https://europepmc.org/articles/PMC4418936/