Rare variants and survival of patients with idiopathic pulmonary fibrosis.

Autor: Alonso-Gonzalez A; Research Unit, Hospital Universitario Nuestra Señora de Candelaria, Instituto de Investigación Sanitaria de Canarias, Santa Cruz de Tenerife, Spain., Jáspez D; Genomics Division, Instituto Tecnológico y de Energías Renovables, Santa Cruz de Tenerife, Spain., Lorenzo-Salazar JM; Genomics Division, Instituto Tecnológico y de Energías Renovables, Santa Cruz de Tenerife, Spain., Ma SF; Division of Pulmonary and Critical Care Medicine, University of Virginia, Charlottesville, VA USA., Strickland E; Division of Pulmonary and Critical Care Medicine, University of Virginia, Charlottesville, VA USA., Mychaleckyj J; Center for Public Health Genomics; University of Virginia, Charlottesville, VA, USA., Kim JS; Division of Pulmonary and Critical Care Medicine, University of Virginia, Charlottesville, VA USA., Huang Y; Division of Pulmonary and Critical Care Medicine, University of Virginia, Charlottesville, VA USA., Adegunsoye A; Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL USA., Oldham JM; Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI USA., Steward I; National Heart and Lung Institute, Imperial College London, London, UK., Molyneaux PL; National Heart and Lung Institute, Imperial College London, London, UK.; Royal Brompton and Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Maher TM; National Heart and Lung Institute, Imperial College London, London, UK.; Division of Pulmonary and Critical Care Medicine, University of Southern California, Los Angeles, CA USA., Wain LV; Department of Population Health Sciences, University of Leicester, Leicester, UK.; National Institute for Health Research, Leicester Respiratory Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Allen RJ; Department of Population Health Sciences, University of Leicester, Leicester, UK.; National Institute for Health Research, Leicester Respiratory Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Jenkins RG; National Heart and Lung Institute, Imperial College London, London, UK., Kropski JA; Department of Cell and Developmental Biology, Vanderbilt University.; Department of Veterans Affairs Medical Center, Nashville, TN.; Division of Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, TN USA., Yaspan B; Genentech Inc., San Francisco, CA USA., Blackwell TS; Department of Internal Medicine, University of Michigan, Ann Arbor, MI USA., Zhang D; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Garcia CK; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.; Columbia Precision Medicine Initiative , Columbia University Irving Medical Center, New York, NY, USA., Martinez FJ; Weill Cornell Medical Center, New York, NY USA., Noth I; Division of Pulmonary and Critical Care Medicine, University of Virginia, Charlottesville, VA USA., Flores C; Research Unit, Hospital Universitario Nuestra Señora de Candelaria, Instituto de Investigación Sanitaria de Canarias, Santa Cruz de Tenerife, Spain.; Genomics Division, Instituto Tecnológico y de Energías Renovables, Santa Cruz de Tenerife, Spain.; Facultad de Ciencias de la Salud, Universidad Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain.; CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Oct 15. Date of Electronic Publication: 2024 Oct 15.

1-year health outcomes associated with systemic corticosteroids for COVID-19: a longitudinal cohort study.

Autor: Leavy OC; Department of Population Health Sciences, University of Leicester, Leicester, UK.; The Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.; These authors contributed equally., Russell RJ; The Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.; These authors contributed equally., Harrison EM; Centre for Medical Informatics, The Usher Institute, University of Edinburgh, Edinburgh, UK., Lone NI; The Usher Institute, University of Edinburgh, Edinburgh, UK.; Royal Infirmary of Edinburgh, NHS Lothian, Edinburgh, UK., Kerr S; Centre for Medical Informatics, The Usher Institute, University of Edinburgh, Edinburgh, UK.; Roslin Institute, University of Edinburgh, Edinburgh, UK., Docherty AB; Centre for Medical Informatics, The Usher Institute, University of Edinburgh, Edinburgh, UK., Sheikh A; The Usher Institute, University of Edinburgh, Edinburgh, UK., Richardson M; The Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK., Elneima O; The Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK., Greening NJ; The Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK., Harris VC; The Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.; University Hospitals of Leicester NHS Trust, Leicester, UK., Houchen-Wolloff L; Centre for Exercise and Rehabilitation Science, NIHR Leicester Biomedical Research Centre-Respiratory, University of Leicester, Leicester, UK.; Department of Respiratory Sciences, University of Leicester, Leicester, UK.; Therapy Department, University Hospitals of Leicester, NHS Trust, Leicester, UK., McAuley HJC; The Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK., Saunders RM; The Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK., Sereno M; The Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK., Shikotra A; NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK., Singapuri A; The Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK., Aul R; St George's University Hospitals NHS Foundation Trust, London, UK., Beirne P; The Leeds Teaching Hospitals NHS Trust, Leeds, UK., Bolton CE; University of Nottingham, Nottingham, UK.; Nottingham University Hospitals NHS Trust, Nottingham, UK.; NIHR Nottingham Biomedical Research Centre, Nottingham, UK., Brown JS; UCL Respiratory, Department of Medicine, University College London, Rayne Institute, London, UK., Choudhury G; University of Edinburgh, Edinburgh, UK.; NHS Lothian, Edinburgh, UK., Diar Bakerly N; Manchester Metropolitan University, Manchester, UK.; Salford Royal NHS Foundation Trust, Manchester, UK., Easom N; Infection Research Group, Hull University Teaching Hospitals, Hull, UK.; University of Hull, Hull, UK., Echevarria C; The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK., Fuld J; Department of Respiratory Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; University of Cambridge, Cambridge, UK.; NIHR Cambridge Clinical Research Facility, Cambridge, UK., Hart N; Lane Fox Respiratory Service, Guy's and St Thomas NHS Foundation Trust, London, UK., Hurst JR; University College London, London, UK.; Royal Free London NHS Foundation Trust, London, UK., Jones M; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.; NIHR Southampton Biomedical Research Centre, University Hospitals Southampton, Southampton, UK., Parekh D; University of Birmingham, Birmingham, UK.; University Hospital Birmingham NHS Foundation Trust, Birmingham, UK., Pfeffer P; Barts Health NHS Trust, London, UK.; Queen Mary University of London, London, UK., Rahman NM; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Oxford, UK.; CAMS Oxford Institute, Oxford, UK., Rowland-Jones S; University of Sheffield, Sheffield, UK.; Sheffield Teaching NHS Foundation Trust, Sheffield, UK., Shah AM; Kings College London, London, UK.; Kings College London NHS Foundation Trust, London, UK., Wootton DG; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.; Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.; NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, University of Liverpool, Liverpool, UK., Jolley C; Kings College London, London, UK.; Kings College London NHS Foundation Trust, London, UK., Thompson AAR; University of Sheffield, Sheffield, UK.; Sheffield Teaching NHS Foundation Trust, Sheffield, UK., Chalder T; Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK.; South London and Maudsley NHS Trust, London, UK., Davies MJ; University Hospitals of Leicester NHS Trust, Leicester, UK.; NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.; Diabetes Research Centre, University of Leicester, Leicester, UK., De Soyza A; Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, UK.; Newcastle upon Tyne Teaching Hospitals Trust, Newcastle upon Tyne, UK., Geddes JR; NIHR Oxford Health Biomedical Research Centre, University of Oxford, Oxford, UK.; Oxford Health NHS Foundation Trust, Oxford, UK., Greenhalf W; Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.; University of Liverpool, Liverpool, UK.; The CRUK Liverpool Experimental Cancer Medicine Centre, Liverpool, UK., Heller S; Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK., Howard L; Imperial College Healthcare NHS Trust, London, UK.; Imperial College London, London, UK., Jacob J; Centre for Medical Image Computing, University College London, London, UK.; Lungs for Living Research Centre, University College London, London, UK., Jenkins RG; National Heart and Lung Institute, Imperial College London, London, UK., Lord JM; MRC Versus Arthritis Centre for Musculoskeletal Ageing Research, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.; NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham and the University of Birmingham, Birmingham, UK., Man WD; Royal Brompton and Harefield Clinical Group, Guy's and St Thomas NHS Foundation Trust, London, UK.; NHLI, Imperial College London, London, UK., McCann GP; NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK., Neubauer S; NIHR Oxford Health Biomedical Research Centre, University of Oxford, Oxford, UK.; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Openshaw PJM; National Heart and Lung Institute, Imperial College London, London, UK., Porter J; UCL Respiratory, Department of Medicine, University College London, Rayne Institute, London, UK.; ILD Service, University College London Hospital, London, UK., Rowland MJ; Kadoorie Centre for Critical Care Research, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Scott JT; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK., Semple MG; NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.; Respiratory Medicine, Alder Hey Children's Hospital, Liverpool, UK., Singh SJ; The Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK., Thomas D; Imperial College London, London, UK., Toshner M; NIHR Cambridge Clinical Research Facility, Cambridge, UK.; Cambridge NIHR BRC, Cambridge, UK., Lewis K; Hywel Dda University Health Board, Wales, UK.; University of Swansea, Wales, UK.; Respiratory Innovation Wales, Wales, UK., Heaney LG; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK.; Belfast Health and Social Care Trust, Belfast, UK., Briggs A; London School of Hygiene and Tropical Medicine, London, UK., Zheng B; London School of Hygiene and Tropical Medicine, London, UK., Thorpe M; Centre for Medical Informatics, The Usher Institute, University of Edinburgh, Edinburgh, UK., Quint JK; NHLI, Imperial College London, London, UK., Chalmers JD; University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., Ho LP; NIHR Oxford Biomedical Research Centre, Oxford, UK.; MRC Human Immunology Unit, University of Oxford, Oxford, UK., Horsley A; Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.; Manchester University NHS Foundation Trust, Manchester, UK., Marks M; Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK.; Hospital for Tropical Diseases, University College London Hospital, London, UK.; Division of Infection and Immunity, University College London, London, UK., Poinasamy K; Asthma and Lung UK, London, UK., Raman B; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Wain LV; Department of Population Health Sciences, University of Leicester, Leicester, UK.; The Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK., Brightling CE; The Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK., Evans RA; The Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.; University Hospitals of Leicester NHS Trust, Leicester, UK.

Publikováno v: ERJ open research [ERJ Open Res] 2024 Sep 30; Vol. 10 (5). Date of Electronic Publication: 2024 Sep 30 (Print Publication: 2024).

Cluster analysis of blood biomarkers to identify molecular patterns in pulmonary fibrosis: assessment of a multicentre, prospective, observational cohort with independent validation.

Autor: Fainberg HP; NIHR Imperial Biomedical Respiratory Research Centre, National Heart and Lung Institute, Imperial College London, London, UK. Electronic address: h.fainberg@imperial.ac.uk., Moodley Y; NHMRC Centre of Research Excellence in Pulmonary Fibrosis, Camperdown, NSW, Australia; Centre for Respiratory Health, School of Biomedical Sciences, University of Western Australia, Nedlands, WA, Australia; Cell Biology Group, Institute for Respiratory Health, Nedlands, WA, Australia; Department of Respiratory Medicine, Fiona Stanley Hospital, Murdoch, WA, Australia., Triguero I; Department of Computer Science and Artificial Intelligence, DaSCI Andalusian Institute in Data Science and Computational Intelligence, University of Granada, Granada, Spain; School of Computer Science, University of Nottingham, Nottingham, UK., Corte TJ; Royal Prince Alfred Hospital, Camperdown, NSW, Australia; The University of Sydney Central Clinical School, Camperdown, NSW, Australia., Sand JMB; Hepatic and Pulmonary Research, Nordic Bioscience, Herlev, Denmark., Leeming DJ; Hepatic and Pulmonary Research, Nordic Bioscience, Herlev, Denmark., Karsdal MA; Hepatic and Pulmonary Research, Nordic Bioscience, Herlev, Denmark., Wells AU; NIHR Imperial Biomedical Respiratory Research Centre, National Heart and Lung Institute, Imperial College London, London, UK; Interstitial Lung Disease Unit, Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust, London, UK., Renzoni E; NIHR Imperial Biomedical Respiratory Research Centre, National Heart and Lung Institute, Imperial College London, London, UK; Interstitial Lung Disease Unit, Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust, London, UK., Mackintosh J; Department of Thoracic Medicine, The Prince Charles Hospital, Brisbane, QLD, Australia., Tan DBA; NHMRC Centre of Research Excellence in Pulmonary Fibrosis, Camperdown, NSW, Australia; Centre for Respiratory Health, School of Biomedical Sciences, University of Western Australia, Nedlands, WA, Australia; Cell Biology Group, Institute for Respiratory Health, Nedlands, WA, Australia., Li R; NHMRC Centre of Research Excellence in Pulmonary Fibrosis, Camperdown, NSW, Australia; Centre for Respiratory Health, School of Biomedical Sciences, University of Western Australia, Nedlands, WA, Australia; Cell Biology Group, Institute for Respiratory Health, Nedlands, WA, Australia., Porte J; Centre for Respiratory Research and NIHR Biomedical Research Centre, University of Nottingham, Nottingham, UK., Braybrooke R; Centre for Respiratory Research and NIHR Biomedical Research Centre, University of Nottingham, Nottingham, UK., Saini G; Centre for Respiratory Research and NIHR Biomedical Research Centre, University of Nottingham, Nottingham, UK., Johnson SR; Centre for Respiratory Research and NIHR Biomedical Research Centre, University of Nottingham, Nottingham, UK., Wain LV; Department of Population Health Sciences, University of Leicester, Leicester, UK; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Molyneaux PL; NIHR Imperial Biomedical Respiratory Research Centre, National Heart and Lung Institute, Imperial College London, London, UK; Interstitial Lung Disease Unit, Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust, London, UK., Maher TM; NIHR Imperial Biomedical Respiratory Research Centre, National Heart and Lung Institute, Imperial College London, London, UK; Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Stewart ID; NIHR Imperial Biomedical Respiratory Research Centre, National Heart and Lung Institute, Imperial College London, London, UK., Jenkins RG; NIHR Imperial Biomedical Respiratory Research Centre, National Heart and Lung Institute, Imperial College London, London, UK; Interstitial Lung Disease Unit, Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust, London, UK.

Publikováno v: The Lancet. Respiratory medicine [Lancet Respir Med] 2024 Sep; Vol. 12 (9), pp. 681-692. Date of Electronic Publication: 2024 Jul 15.

TOLLIP SNP and Antimicrobial Treatment Effect in Idiopathic Pulmonary Fibrosis.

Autor: Whalen W; Division of Pulmonary and Critical Care, Department of Medicine., Berger K; Division of Pulmonary and Critical Care, Department of Medicine., Kim JS; Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia., Simmons W; Division of Biostatistics, Department of Population Health Sciences, and., Ma SF; Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia., Kaner RJ; Division of Pulmonary and Critical Care, Department of Medicine.; Department of Genetic Medicine, New York Presbyterian-Weill Cornell Medicine, New York, New York., Martinez FJ; Division of Pulmonary and Critical Care, Department of Medicine., Anstrom KJ; University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina., Parfrey H; University of Cambridge and Royal Papworth Hospital National Health Service Foundation Trust, Cambridge, United Kingdom., Maher TM; University of Southern California, Los Angeles, California.; National Heart and Lung Institute, Imperial Biomedical Research Centre, and National Institute for Health and Care Research Margaret Turner Warwick Centre for Fibrosing Lung Disease, Imperial College London, London, United Kingdom., Hammond M; Norwich Clinical Trials Unit and., Clark AB; Norwich Clinical Trials Unit and., Thickett D; Institute of Inflammation and Aging, University of Birmingham, Birmingham, United Kingdom., Jenkins RG; National Heart and Lung Institute, Imperial Biomedical Research Centre, and National Institute for Health and Care Research Margaret Turner Warwick Centre for Fibrosing Lung Disease, Imperial College London, London, United Kingdom., Wilson AM; Norwich Medical School, University of East Anglia, Norwich, United Kingdom; and., Noth I; Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia.

Publikováno v: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2024 Aug 15; Vol. 210 (4), pp. 508-511.

Phase 2, Double-Blind, Placebo-controlled Trial of a c-Jun N-Terminal Kinase Inhibitor in Idiopathic Pulmonary Fibrosis.

Autor: Mattos WLLD; Hospital Nossa Senhora da Conceição, Porto Alegre, Brazil., Khalil N; Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Spencer LG; Aintree Chest Centre, Liverpool University Hospital NHS Foundation Trust, Liverpool, United Kingdom., Bonella F; Center for Interstitial and Rare Lung Disease, Department of Pneumology, Ruhrlandklinik, University of Duisburg-Essen, Essen, Germany., Folz RJ; Division of Pulmonary, Critical Care and Sleep Medicine, Houston Methodist Research Institute, Houston, Texas., Rolf JD; Kelowna Respiratory Clinic, Kelowna, British Columbia, Canada., Mogulkoc N; Department of Pulmonary Medicine, Ege University Hospital, Izmir, Turkey., Lancaster LH; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Jenkins RG; Imperial Biomedical Research Center and.; Royal Brompton and Harefield Hospital, London, United Kingdom., Lynch DA; Department of Radiology, National Jewish Health, Denver, Colorado., Noble PW; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California., Maher TM; Interstitial Lung Disease Unit, National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Keck School of Medicine, University of Southern California, Los Angeles, California., Cottin V; Department of Respiratory Medicine, Louis Pradel Hospital, Lyon, France.; University Claude Bernard Lyon 1, UMR 754, INRAE, Lyon, France., Senger S; Bristol Myers Squibb, Princeton, New Jersey; and.; Cytel Inc., Waltham, Massachusetts., Horan GS; Bristol Myers Squibb, Princeton, New Jersey; and., Greenberg S; Bristol Myers Squibb, Princeton, New Jersey; and., Popmihajlov Z; Bristol Myers Squibb, Princeton, New Jersey; and.

Publikováno v: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2024 Aug 15; Vol. 210 (4), pp. 435-443.