Robust Quantification of Phosphodiesterase-4D in Monkey Brain with PET and ¹¹C-Labeled Radioligands That Avoid Radiometabolite Contamination.

Autor: Meijuan Jiang, Shiyu Tang, Jenkins, Madeline D., Lee, Adrian C., Kenou, Bruny, Knoer, Carson, Santamaria, Jose Montero, Shawn Wu, Liow, Jeih-San, Zoghbi, Sami S., Zanotti-Fregonara, Paolo, Innis, Robert B., Telu, Sanjay, Pike, Victor W.

Publikováno v: Journal of Nuclear Medicine; Aug2024, Vol. 65 Issue 8, p1-6, 6p

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

First-in-Human Evaluation of ¹⁸F-PF-06445974, a PET Radioligand That Preferentially Labels Phosphodiesterase-4B.

Autor: Yuichi Wakabayashi, Stenkrona, Per, Arakawa, Ryosuke, Xuefeng Yan, Van Buskirk, Maia G., Jenkins, Madeline D., Santamaria, Jose A. Montero, Maresca, Kevin P., Akihiro Takano, Liow, Jeih-San, Chappie, Thomas A., Varrone, Andrea, Nag, Sangram, Lei Zhang, Hughes, Zoë A., Schmidt, Christopher J., Doran, Shawn D., Mannes, Andrew, Zanotti-Fregonara, Paolo, Ooms, Maarten

Publikováno v: Journal of Nuclear Medicine; Dec2022, Vol. 63 Issue 12, p1919-1924, 6p

Discovery of a High-Affinity Fluoromethyl Analog of [ ¹¹ C]5-Cyano- N -(4-(4-methylpiperazin-1-yl)-2-(piperidin-1-yl)phenyl)furan-2-carboxamide ([ ¹¹ C]CPPC) and Their Comparison in Mouse and Monkey as Colony-Stimulating Factor 1 Receptor Positron Emission Tomography Radioligands.

Autor: Altomonte S; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health Building 10, B3 C346A, 10 Center Drive, Bethesda, Maryland 20892, United States., Yan X; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health Building 10, B3 C346A, 10 Center Drive, Bethesda, Maryland 20892, United States., Morse CL; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health Building 10, B3 C346A, 10 Center Drive, Bethesda, Maryland 20892, United States., Liow JS; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health Building 10, B3 C346A, 10 Center Drive, Bethesda, Maryland 20892, United States., Jenkins MD; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health Building 10, B3 C346A, 10 Center Drive, Bethesda, Maryland 20892, United States., Montero Santamaria JA; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health Building 10, B3 C346A, 10 Center Drive, Bethesda, Maryland 20892, United States., Zoghbi SS; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health Building 10, B3 C346A, 10 Center Drive, Bethesda, Maryland 20892, United States., Innis RB; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health Building 10, B3 C346A, 10 Center Drive, Bethesda, Maryland 20892, United States., Pike VW; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health Building 10, B3 C346A, 10 Center Drive, Bethesda, Maryland 20892, United States.

Publikováno v: ACS pharmacology & translational science [ACS Pharmacol Transl Sci] 2023 Mar 10; Vol. 6 (4), pp. 614-632. Date of Electronic Publication: 2023 Mar 10 (Print Publication: 2023).