Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Jenifer, Thewalt"'
Autor:
Tejas Phaterpekar, Jenifer Thewalt, Reza Siavashi, Sherry S.W. Leung, Alicia Alonso, Félix M. Goñi
Publikováno v:
Biophysical Journal. 117:296-306
Sphingolipids constitute a significant fraction of cellular plasma membrane lipid content. Among sphingolipids, ceramide levels are usually very low. However, in some cell processes like apoptosis, cell membrane ceramide levels increase markedly beca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07c67bd64d41fcca221ea8dbc46d6593
https://doi.org/10.1016/j.bpj.2019.05.027
https://doi.org/10.1016/j.bpj.2019.05.027
Autor:
Tagore S. Bandaru, Lucie Delemotte, Mohammad-Reza Ghovanloo, Olaf S. Andersen, Karen Nelkenbrecher, Jenifer Thewalt, Koushik Choudhury, Mohamed A. Fouda, Kaveh Rayani, Peter C. Ruben, Samuel J. Goodchild, Radda Rusinova, Damon Poburko, Tejas Phaterpekar, Abeline R. Watkins
Publikováno v:
The Journal of General Physiology
Ghovanloo et al. combined in silico and in vitro approaches to determine the mechanism by which CBD inhibits the skeletal muscle Na+ channel Nav1.4. Their findings suggest that CBD acts directly, by binding inside the Nav1.4 pore, as well as indirect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bf43d6793ca2a56262e33cb024d91e8
https://doi.org/10.1085/jgp.202012701
https://doi.org/10.1085/jgp.202012701
Autor:
Radda Rusinova, Damon Poburko, Karen Nelkenbrecher, Mohamed A. Fouda, Jenifer Thewalt, Samuel J. Goodchild, Koushik Choudhury, Olaf S. Andersen, Kaveh Rayani, Abeline R. Watkins, Tejas Phaterpekar, Mohammad-Reza Ghovanloo, Tagore S. Bandaru, Lucie Delemotte, Peter C. Ruben
Cannabis sativa contains active constituents called phytocannabinoids. Some phytocannabinoids are psychotropic and others are not. The primary non-psychotropic phytocannabinoid is cannabidiol (CBD), which is proposed to be therapeutic against many co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::492ceb9e6fa1253e1919317a38d39a16
https://doi.org/10.1101/2020.06.30.180943
https://doi.org/10.1101/2020.06.30.180943
Publikováno v:
Langmuir. 33:14405-14413
We report here the first exploration of the nature of the hydrophobic region of bilayer membranes formed from sterol-modified phospholipids [Huang, Z.; Szoka, F. C., Sterol-Modified Phospholipids: Cholesterol and Phospholipid Chimeras with Improved B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0f793fe927f5defcba7f02735c6f61
https://doi.org/10.1021/acs.langmuir.7b03299
https://doi.org/10.1021/acs.langmuir.7b03299
Autor:
Mohsen Ramezanpour, Miranda L. Schmidt, Jayesh A. Kulkarni, Iulia Bodnariuc, Pieter R. Cullis, Jenifer Thewalt, Sherry S.W. Leung, D. P. Tieleman
Publikováno v:
Nanoscale. 11(30)
Lipid nanoparticles (LNPs) composed of ionizable cationic lipids are currently the leading systems for siRNA delivery in liver disease, with the major limitation of low siRNA release efficacy into the cytoplasm. Ionizable cationic lipids are known to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44448d88d37cc7b4877fcf6f168e7e12
https://pubmed.ncbi.nlm.nih.gov/31334542
https://pubmed.ncbi.nlm.nih.gov/31334542
Autor:
Jenifer Thewalt, D. Peter Tieleman
Publikováno v:
Journal of Drug Targeting. 24:768-773
We are on the cusp of a new era in therapeutics which will be characterized by drugs that can be individually tailored to a patient to be more effective and less likely to cause side effects. One of the most successful ways to deliver such drugs to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d882adb5d40bd9516ff63c9b1018e76
https://doi.org/10.1080/1061186x.2016.1221957
https://doi.org/10.1080/1061186x.2016.1221957
Computational and experimental approaches for investigating nanoparticle-based drug delivery systems
Autor:
Jenifer Thewalt, Sherry S.W. Leung, Mohsen Ramezanpour, D. P. Tieleman, Karelia H. Delgado-Magnero, Bashe Y. M. Bashe
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1858:1688-1709
Most therapeutic agents suffer from poor solubility, rapid clearance from the blood stream, a lack of targeting, and often poor translocation ability across cell membranes. Drug/gene delivery systems (DDSs) are capable of overcoming some of these bar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3a32f657fe6657ae244eea64a95048c
https://doi.org/10.1016/j.bbamem.2016.02.028
https://doi.org/10.1016/j.bbamem.2016.02.028
Publikováno v:
Biophysical Journal. 118:389a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff759e838c3bb4c3cf2f09788df732b8
https://doi.org/10.1016/j.bpj.2019.11.2217
https://doi.org/10.1016/j.bpj.2019.11.2217
Autor:
Maria M. Darjuan, Roy van der Meel, Sam Chen, Jayesh A. Kulkarni, Pieter R. Cullis, Yuen Yi C. Tam, Jenifer Thewalt, Joanne E. Mercer
Publikováno v:
ACS Nano, 12(5), 4787. American Chemical Society
Lipid nanoparticles (LNPs) containing short interfering RNA (LNP-siRNA) and optimized ionizable cationic lipids are now clinically validated systems for silencing disease-causing genes in hepatocytes following intravenous administration. However, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10de66175324329e292196cf1ddbfd68
https://dspace.library.uu.nl/handle/1874/366568
https://dspace.library.uu.nl/handle/1874/366568
We have studied the dependence of the phase and domain characteristics of sphingomyelin (SM)/cholesterol model membranes on sterol content and temperature using deuterium nuclear magnetic resonance. NMR spectra of N-palmitoyl(D31)-D-erythro-sphingosy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b56e84445d1af36a4ed8a2d82597824d
https://europepmc.org/articles/PMC5883621/
https://europepmc.org/articles/PMC5883621/