Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Jenifer, Saffi"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Colorectal carcinoma (CRC) is the third most common malignancy worldwide, and second in number of deaths in the world. The molecular pathogenesis of CRC is heterogeneous and can affect several genes. Moreover, genomic instability is recogniz
Externí odkaz:
https://doaj.org/article/de6bd27820924a85bf5a3e294b5e5846
Autor:
Verônica Bidinotto Brito, Leopoldo Vinicius Martins Nascimento, Dinara Jaqueline Moura, Jenifer Saffi
Publikováno v:
Arquivos Brasileiros de Cardiologia, Vol 117, Iss 6, Pp 1147-1158 (2021)
Resumo Fundamento A doxorrubicina (DOX) é frequentemente usada para tratar muitos tipos de cânceres, apesar da cardiotoxicidade dose-dependente. Como alternativa, o resveratrol é um polifenol que tem demonstrado efeitos cardioprotetores em vários
Externí odkaz:
https://doaj.org/article/1f57c5aab56e4807b904cc71442fe5f7
Autor:
Daniel de Barcellos Azambuja, Helena de Castro e Gloria, Gabriel e Silva Montenegro, Antonio Nocchi Kalil, Jean-Sébastien Hoffmann, Natalia Motta Leguisamo, Jenifer Saffi
Publikováno v:
Genes, Vol 14, Iss 6, p 1270 (2023)
Background: Homologous recombination repair (HR) is the most accurate repair pathway for double-strand breaks and replication fork disruption that is capable of faithfully restoring the original nucleotide sequence of the broken DNA. The deficiency o
Externí odkaz:
https://doaj.org/article/f295c914852b4ec29442c0d5954c0895
Autor:
Helena de Castro e Gloria, Laura Jesuíno Nogueira, Patrícia Bencke Grudzinski, Paola Victória da Costa Ghignatti, Temenouga Nikolova Guecheva, Natalia Motta Leguisamo, Jenifer Saffi
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-13 (2021)
Abstract Background The advances in colorectal cancer (CRC) treatment include the identification of deficiencies in Mismatch Repair (MMR) pathway to predict the benefit of adjuvant 5-fluorouracil (5-FU) and oxaliplatin for stage II CRC and immunother
Externí odkaz:
https://doaj.org/article/dcf276d4558c4c30b375683e31671e78
Autor:
Adriana Castro Pinheiro, Ianka Jacondino Nunes, Wesley Vieira Ferreira, Paula Pellenz Tomasini, Cristiano Trindade, Carolina Cristóvão Martins, Ethel Antunes Wilhelm, Robson da Silva Oliboni, Paulo Augusto Netz, Rafael Stieler, Osvaldo de Lazaro Casagrande, Jenifer Saffi
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 376 (2023)
Cu(II) complexes bearing NNO-donor Schiff base ligands (2a, b) have been synthesized and characterized. The single crystal X-ray analysis of the 2a complex revealed that a mononuclear and a dinuclear complex co-crystallize in the solid state. The ele
Externí odkaz:
https://doaj.org/article/db83ae18b7a443f0a9f58f90185166d4
Autor:
Franciele Faccio Busatto, Sofiane Y. Mersaoui, Yilun Sun, Yves Pommier, Jean-Yves Masson, Jenifer Saffi
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Topoisomerase 2 (TOP2) inhibitors are drugs widely used in the treatment of different types of cancer. Processing of their induced-lesions create double-strand breaks (DSBs) in the DNA, which is the main toxic mechanism of topoisomerase inhibitors to
Externí odkaz:
https://doaj.org/article/45e3879ae15d4f908ae61d3a9d47acfa
Autor:
Daniel de Barcelos Azambuja, Helena de Castro E Glória, Gabriel e Silva Montenegro, Antonio Nocchi Kalil, Jean-Sébastien Hoffmann, Natalia Leguisamo, Jenifer Saffi
Background: Homologous Recombination (HR) is the most accurate repair pathway for double-strand breaks and replication fork disruption that is capable of faithfully restoring the original nucleotide sequence of the broken DNA. The deficiency in this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de356d2867fa747217d699c151d7f363
https://doi.org/10.20944/preprints202305.1126.v1
https://doi.org/10.20944/preprints202305.1126.v1
Autor:
Paula Pellenz Tomasini, Temenouga Nikolova Guecheva, Natalia Motta Leguisamo, Sarah Péricart, Anne-Cécile Brunac, Jean Sébastien Hoffmann, Jenifer Saffi
Publikováno v:
Cancers, Vol 13, Iss 13, p 3130 (2021)
Despite the ample improvements of CRC molecular landscape, the therapeutic options still rely on conventional chemotherapy-based regimens for early disease, and few targeted agents are recommended for clinical use in the metastatic setting. Moreover,
Externí odkaz:
https://doaj.org/article/8532efca07654885bea4462d8b20995f
Autor:
Bruna Donida, Desirèe P. Marchetti, Carlos Eduardo Diaz Jacques, Graziela Ribas, Marion Deon, Paula Manini, Helen Tais da Rosa, Dinara Jaqueline Moura, Jenifer Saffi, Roberto Giugliani, Carmen Regla Vargas
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 11, Iss C, Pp 46-53 (2017)
Morquio A disease (Mucopolysaccharidosis type IVA, MPS IVA) is one of the 11 mucopolysaccharidoses (MPSs), a heterogeneous group of inherited lysosomal storage disorders (LSDs) caused by deficiency in enzymes need to degrade glycosaminoglycans (GAGs)
Externí odkaz:
https://doaj.org/article/fe0ec210696843fbbba3498aa68f3530
Autor:
Camila Simioni Vanzin, Caroline Paula Mescka, Bruna Donida, Desirèe Padilha Marchetti, Carlos Eduardo Jacques, Tatiane Hauschild, Jéssica Lamberty Faverzani, Marion Deon, Dinara Moura, Jenifer Saffi, Daniella de Moura Coelho, Moacir Wajner, Angela T.S. Wyse, Carmen Regla Vargas
Publikováno v:
Clinical and Biomedical Research, Vol 38, Iss 1 (2018)
Introduction: Homocysteine (Hcy) tissue accumulation occurs in a metabolic disease characterized biochemically by cystathionine β-synthase (CBS) deficiency and clinically by mental retardation, vascular problems, and skeletal abnormalities. Previous
Externí odkaz:
https://doaj.org/article/b36ae36dd098482790e2470350a1ab3d