Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Jenica D. Tapocik"'
Autor:
Jenica D. Tapocik, Kristin eCeniccola, Cheryl L. Mayo, Melanie L Schwandt, Matthew eSolomon, Bi-Dar eWang, Truong V. Luu, Jacqueline eOlender, Thomas eHarrigan, Thomas M. Maynard, Greg I Elmer, Norman H. Lee
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 9 (2016)
Long-term opioid treatment results in reduced therapeutic efficacy and in turn leads to an increase in the dose required to produce equivalent pain relief and alleviate break-through or insurmountable pain. Altered gene expression is a likely means f
Externí odkaz:
https://doaj.org/article/328cfb36e42f4af0a689410a753f2090
Autor:
Markus Heilig, A.B. Pincus, R. Damazdic, Courtney E. King, Cheryl L. Mayo, Jenica D. Tapocik, Dana L. Brady, J.R. Mitchell, Jesse R. Schank, Gregory I. Elmer
Publikováno v:
Behav Brain Res
Exposure to traumatic events during childhood increases the risk of adult psychopathology, including anxiety, depression, alcohol use disorders and their co-morbidity. Early life trauma also results in increased symptom complexity, treatment resistan
Autor:
April N. Le, Lorenzo Leggio, Lisa A. Farinelli, Enoch Cobbina, Jenica D. Tapocik, Fatemeh Akhlaghi, Mwlod Ghareeb, Mehdi Farokhnia, Alexandra A. Dias, Markus Heilig, Mary R. Lee, Melanie L. Schwandt, Sofia Bouhlal
Publikováno v:
Molecular psychiatry
Rodent studies indicate that ghrelin receptor blockade reduces alcohol consumption. However, no ghrelin receptor blockers have been administered to heavy alcohol drinking individuals. Therefore, we evaluated the safety, tolerability, pharmacokinetic
Autor:
Jenica D. Tapocik, Marcus W. Meinhardt, Andrea L. Johnstone, Simone Pfarr, Estelle Barbier, Wolfgang H. Sommer, Claes Wahlestedt, Markus Heilig
Publikováno v:
Genes, Brain and Behavior. 16:86-100
Despite its limited immediate reinforcement value, alcohol has a potent ability to induce neuroadaptations that promote its incentive salience, escalation of voluntary alcohol intake and aversion resistant alcohol seeking. A constellation of these tr
Autor:
Esi Domi, Samara Vilca, Christopher A. Rienas, Bohdan B. Khomtchouk, Zane Zeier, Danielle Maryanski, Nadja S. Andrade, Jenica D. Tapocik, Markus Heilig, Keli L. Rodriguez, Derek J. Van Booven, Estelle Barbier, Andrea L. Johnstone, Rustam Esanov, Claes Wahlestedt, Michael-Christopher Keogh, Marcus W. Meinhardt, Kenneth Lowe, Wolfgang H. Sommer
Publikováno v:
Addiction Biology
Epigenetic enzymes oversee long‐term changes in gene expression by integrating genetic and environmental cues. While there are hundreds of enzymes that control histone and DNA modifications, their potential roles in substance abuse and alcohol depe
Autor:
Jenica D. Tapocik, Andrea L. Johnstone, Bohdan B. Khomtchouk, Claes Wahlestedt, Daniel Nätt, Jesse R. Schank, Eric Augier, D. J. Van Booven, Caleb Pitcairn, A. Borich, Faazal Rehman, Estelle Barbier, Markus Heilig, Hui Sun, C. A. Rienas
Publikováno v:
Europe PubMed Central
Molecular psychiatry
Molecular psychiatry
Epigenetic processes have been implicated in the pathophysiology of alcohol dependence, but the specific molecular mechanisms mediating dependence-induced neuroadaptations remain largely unknown. Here, we found that a history of alcohol dependence pe
Autor:
Annika Thorsell, Matthew Solomon, Camilla Karlsson, Faazal Rehman, Jesse R. Schank, Markus Heilig, Andrea Stojakovic, Jenica D. Tapocik, Estelle Barbier, David Engblom, Karl Björk
Publikováno v:
Addiction Biology. 22:1279-1288
Proinflammatory activity has been postulated to play a role in addictive processes and stress responses, but the underlying mechanisms remain largely unknown. Here, we examined the role of interleukin 1 (IL-1) and tumor necrosis factor-α (TNF-α) in
Publikováno v:
Pharmacol Biochem Behav
Early life trauma dramatically increases the risk of developing major depressive disorder (MDD), and is associated with a markedly decreased adult treatment response to antidepressants. Novel treatment approaches are required to treat childhood traum
Autor:
Jenica D. Tapocik, Alexandra Pincus, Andrew Pilling, Hui Sun, Matthew Solomon, Jesse R. Schank, Markus Heilig, Meghan E. Flanigan, Estelle Barbier, Courtney E. King
Publikováno v:
The Journal of Neuroscience. 34:4581-4588
Escalation of voluntary alcohol consumption is a hallmark of alcoholism, but its neural substrates remain unknown. In rats, escalation occurs following prolonged exposure to cycles of alcohol intoxication, and is associated with persistent, wide-rang
Autor:
Colin A. Hodgkinson, Jenica D. Tapocik, Eric Augier, Markus Heilig, Wei Xiong, Qiaoping Yuan, Mitsuru Kimura, Howard J. Edenberg, Pei Hong Shen, Estelle Barbier, Camilla Karlsson, David M. Lovinger, Austin Y. Feng, Mary Anne Enoch, David Goldman, Zhifeng Zhou, Tiebing Liang, Meghan E. Flanigan
Publikováno v:
Proceedings of the National Academy of Sciences. 110:16963-16968
Identification of genes influencing complex traits is hampered by genetic heterogeneity, the modest effect size of many alleles, and the likely involvement of rare and uncommon alleles. Etiologic complexity can be simplified in model organisms. By ge