Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Jeng P. Lu"'
Publikováno v:
Discover Psychology, Vol 4, Iss 1, Pp 1-9 (2024)
Abstract Researchers have identified university students and military personnel as highly susceptible to the stress and emotional challenges imposed by the Coronavirus disease 2019 (COVID-19) pandemic. The objective of this study was to compare the p
Externí odkaz:
https://doaj.org/article/853e3da99c5741058a4842289240e01f
Autor:
Sophia Engelhard, Montserrat Estruch, Shuyu Qin, Christoph A. Engelhard, Francisco G. Rodriguez-Gonzalez, Martine Drilsvik, Javier Martin-Gonzalez, Jeng-Wei Lu, David Bryder, Claus Nerlov, Joachim Weischenfeldt, Kristian Reckzeh, Kim Theilgaard-Mönch
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114475- (2024)
Summary: Endomucin (EMCN) currently represents the only hematopoietic stem cell (HSC) marker expressed by both murine and human HSCs. Here, we report that EMCN+ long-term repopulating HSCs (LT-HSCs; CD150+CD48−LSK) have a higher long-term multi-lin
Externí odkaz:
https://doaj.org/article/3dfc405563e042acaabd1378d8d20651
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 12, Pp 1187-1197 (2018)
KRAS mutations are a major risk factor in colorectal cancers. In particular, a point mutation of KRAS of amino acid 12, such as KRAS V12, renders it stable activity in oncogenesis. We found that krasV12 promotes intestinal carcinogenesis by generatin
Externí odkaz:
https://doaj.org/article/c9e9fa6f0c21499e86361cff4ad79ced
Autor:
Yan Li, Ai Qi Lee, Zhiyuan Lu, Yuxi Sun, Jeng-Wei Lu, Ziheng Ren, Na Zhang, Dong Liu, Zhiyuan Gong
Publikováno v:
Cells, Vol 11, Iss 11, p 1810 (2022)
The crosstalk between tumors and their local microenvironment has been well studied, whereas the effect of tumors on distant tissues remains understudied. Studying how tumors affect other tissues is important for understanding the systemic effect of
Externí odkaz:
https://doaj.org/article/b91e75bcf60d4eaa9d5e7a7542f072c9
Autor:
Tzu-Chun Kan, Mei-Hsiang Lin, Chun-Chia Cheng, Jeng-Wei Lu, Ming-Thau Sheu, Yuan-Soon Ho, Sri Rahayu, Jungshan Chang
Publikováno v:
Pharmaceutics, Vol 14, Iss 4, p 839 (2022)
Cisplatin is one of the most common therapeutics used in treatments of several types of cancers. To enhance cisplatin lipophilicity and reduce resistance and side effects, a polyfluorinated bipyridine-modified cisplatin analogue, dichloro[4,4’-bis(
Externí odkaz:
https://doaj.org/article/544131621a934047b7c9de05ddc9bc17
Autor:
Giimel Ajnai, Chun-Chia Cheng, Tzu-Chun Kan, Jeng-Wei Lu, Sri Rahayu, Amy Chiu, Jungshan Chang
Publikováno v:
Pharmaceutics, Vol 14, Iss 4, p 847 (2022)
Tumor hypoxia is a hallmark of solid tumors and emerged as the therapeutic target for cancer treatments, such as a prodrug Tirapazamine (TPZ) activated in hypoxia. To increase tumor accumulation, gold nanoparticles (GNPs) were selected to conjugate w
Externí odkaz:
https://doaj.org/article/aad744552299478a892f4cfecdeccfa4
Publikováno v:
Biomedicines, Vol 10, Iss 1, p 95 (2022)
The poor prognosis of patients diagnosed with hepatocellular carcinoma (HCC) is directly associated with the multi-step process of tumor metastasis. TWIST1, a basic helix-loop-helix (bHLH) transcription factor, is the most important epithelial-mesenc
Externí odkaz:
https://doaj.org/article/7db9503a94aa410bbf718708f2841e95
Autor:
Yu-Hsuan Fu, Chi-Yang Tseng, Jeng-Wei Lu, Wen-Hui Lu, Pei-Qi Lan, Chien-Yuan Chen, Da-Liang Ou, Liang-In Lin
Publikováno v:
Biomedicines, Vol 9, Iss 12, p 1869 (2021)
Pyrvinium pamoate, a widely-used anthelmintic agent, reportedly exhibits significant anti-tumor effects in several cancers. However, the efficacy and mechanisms of pyrvinium against myeloid leukemia remain unclear. The growth inhibitory effects of py
Externí odkaz:
https://doaj.org/article/9c8b24e3337a444b99a06965c2eb87d3
Publikováno v:
Biomedicines, Vol 9, Iss 8, p 974 (2021)
Intestinal carcinogenesis is a multistep process that begins with epithelial hyperplasia, followed by a transition to an adenoma and then to a carcinoma. Many etiological factors, including KRAS mutations and inflammation, have been implicated in onc
Externí odkaz:
https://doaj.org/article/88e411ba8b734eca8d39e11ef544c015
Publikováno v:
Pharmaceuticals, Vol 14, Iss 9, p 867 (2021)
The poor prognosis for patients with hepatocellular carcinoma (HCC) is related directly to metastasis. The Twist1 gene encodes for a transcription factor essential to embryogenesis. It has also been shown to promote epithelial-to-mesenchymal transiti
Externí odkaz:
https://doaj.org/article/02de9608b77b4c8fb4f4298d6e79b639