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Amplified in breast cancer 1 expression in breast cancer

Autor: Mangesh A. Thorat, Dmitry Turbin, David G. Huntsman, Akira Morimiya, Harikrishna Nakshatri, Jeng Mh, Zhang Q, Samuel Leung, Sunil Badve

Publikováno v: Histopathology. 53:634-641

Aims: The amplified in breast cancer 1 (AIB1), steroid receptor co-activator family member, acts as an oestrogen receptor (ER) co-activator. Acting with HER-2, it is thought to play a role in endocrine resistance by facilitating ER–growth factor cr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ded495651d464fbd488a8ababc0d3fea
https://doi.org/10.1111/j.1365-2559.2008.03155.x

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HOXB13 is downregulated in colorectal cancer to confer TCF4-mediated transactivation

Autor: Chaeyong Jung, Lee Sj, Jeng Mh, Hao Zhang, H. Sheng, Kim Rs, Thomas A. Gardner, Patrick J. Loehrer, C. Kao

Publikováno v: British Journal of Cancer

Mutations in the Wnt signalling cascade are believed to cause aberrant proliferation of colorectal cells through T-cell factor-4 (TCF4) and its downstream growth-modulating factors. HOXB13 is exclusively expressed in prostate and colorectum. In prost

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20595bb3344bc927710ecf64a6ab86e2
https://doi.org/10.1038/sj.bjc.6602631

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Adaptive hypersensitivity to estrogen: mechanism for superiority of aromatase inhibitors over selective estrogen receptor modulators for breast cancer treatment and prevention

Autor: Richard J. Santen, Zhang Z, Wei Yue, Berstein L, Shigeru Masamura, Jeng Mh, Robert X.-D. Song, Rakesh Kumar

Publikováno v: Endocrine-related cancer. :111-130

Clinical observations suggest that human breast tumors can adapt to endocrine therapy by developing hypersensitivity to estradiol (E(2)). To understand the mechanisms responsible, we examined estrogenic stimulation of cell proliferation in a model sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65084cc387ad27b4a5ce4bd89a47e1ab
https://doi.org/10.1677/erc.0.0100111

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Adaptive mechanisms induced by long-term estrogen deprivation in breast cancer cells

Autor: Richard J. Santen, Liana Adam, Wei Yue, Robert X.-D. Song, S Masamura, Jeng Mh, Rakesh Kumar

Publikováno v: Molecular and Cellular Endocrinology. 193:29-42

Clinical observations suggest that human breast tumors can adapt in response to endocrine therapy by developing hypersensitivity to estradiol. To understand the mechanisms responsible, we examined estrogenic stimulation of cell proliferation in a mod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37899cf90a0fa54279d3aa0e12a39742
https://doi.org/10.1016/s0303-7207(02)00093-x

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Long-term estradiol deprivation in breast cancer cells up-regulates growth factor signaling and enhances estrogen sensitivity

Autor: J. Lawrence, Wei Yue, Richard J. Santen, Masamura A, Berstein L, Zhang Z, Rakesh Kumar, Robert X.-D. Song, Jeng Mh

Publikováno v: Endocrine-related cancer. 12

Deprivation of estrogen causes breast tumors in women to adapt and develop enhanced sensitivity to this steroid. Accordingly, women relapsing after treatment with oophorectomy, which substantially lowers estradiol for a prolonged period, respond seco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8a6e22bc84b55f5cc19f3a441b28574
https://pubmed.ncbi.nlm.nih.gov/16113100

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Adaptive hypersensitivity to estrogen: mechanisms and clinical relevance to aromatase inhibitor therapy in breast cancer treatment

Autor: L.P. MacMahon, Richard J. Santen, Zhang Z, Jeng Mh, Rakesh Kumar, L. Berstein, J. Lawrence, Wei Yue, R.X. Song, Shigeru Masamura

Publikováno v: The Journal of steroid biochemistry and molecular biology. 95(1-5)

Breast tumors in women can adapt to endocrine deprivation therapy by developing hypersensitivity to estradiol. For this reason, aromatase inhibitors can be effective in women relapsing after treatment with tamoxifen or following oophorectomy. To unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2396a28da420bb2a08ecb5564f073457
https://pubmed.ncbi.nlm.nih.gov/16024245

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