Výsledky vyhledávání - "Jenell R Smith"

Akademický článek

Salmon and human thrombin differentially regulate radicular pain, glial-induced inflammation and spinal neuronal excitability through protease-activated receptor-1.

Autor: Jenell R Smith, Peter P Syre, Shaina A Oake, Kristen J Nicholson, Christine L Weisshaar, Katrina Cruz, Robert Bucki, Bethany C Baumann, Paul A Janmey, Beth A Winkelstein

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e80006 (2013)

Chronic neck pain is a major problem with common causes including disc herniation and spondylosis that compress the spinal nerve roots. Cervical nerve root compression in the rat produces sustained behavioral hypersensitivity, due in part to the earl

Externí odkaz: https://doaj.org/article/6b96131a04ba44b08e106a53dbb32f8a

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Nerve Root Compression Increases Spinal Astrocytic Vimentin in Parallel With Sustained Pain and Endothelial Vimentin in Association With Spinal Vascular Reestablishment

Autor: Jenell R. Smith, Jasmine Lee, Beth A. Winkelstein

Publikováno v: Spine. 42:1434-1439

Temporal immunohistochemistry analysis of spinal cord tissue from a rat model of cervical radiculopathy.The goal was to measure spinal endothelial and astrocytic vimentin expression after a painful nerve root compression to define spinal cellular exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c5b40f7c1fa990f77e978cbf4c7420
https://doi.org/10.1097/brs.0000000000002103

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A Synthetic Agonist to Vasoactive Intestinal Peptide Receptor-2 Induces Regulatory T Cell Neuroprotective Activities in Models of Parkinson’s Disease

Autor: Krista L. Namminga, Scott Shandler, R. Lee Mosley, Jenell R. Smith, Jatin Machhi, Yaman Lu, Wenhui Yan, Howard E. Gendelman, Katherine E. Olson

Publikováno v: Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience, Vol 13 (2019)

A paradigm shift has emerged in Parkinson’s disease (PD) highlighting the prominent role of CD4+ Tregs in pathogenesis and treatment. Bench to bedside research, conducted by others and our own laboratories, advanced a neuroprotective role for Tregs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c51025ac3b78ba493c4c181597e40ae0
http://europepmc.org/articles/PMC6759633

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Burst and Tonic Spinal Cord Stimulation Differentially Activate GABAergic Mechanisms to Attenuate Pain in a Rat Model of Cervical Radiculopathy

Autor: Christine L. Weisshaar, Melanie D. Goodman-Keiser, Beth A. Winkelstein, Nathan D. Crosby, Martha E. Zeeman, Jenell R. Smith

Publikováno v: IEEE Transactions on Biomedical Engineering. 62:1604-1613

Objective: Spinal cord stimulation (SCS) is widely used to treat neuropathic pain. Burst SCS, an alternative mode of stimulation, reduces neuropathic pain without paresthesia. However, the effects and mechanisms of burst SCS have not been compared to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59c7c645530ae69eccc40a700c024a7e
https://doi.org/10.1109/tbme.2015.2399374

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Stimulation Parameters Define the Effectiveness of Burst Spinal Cord Stimulation in a Rat Model of Neuropathic Pain

Autor: Nathan D. Crosby, Martha E. Zeeman, Jenell R. Smith, Melanie D. Goodman Keiser, Beth A. Winkelstein

Publikováno v: Neuromodulation: Technology at the Neural Interface. 18:1-8

Introduction Although burst spinal cord stimulation (SCS) has been reported to reduce neuropathic pain, no study has explicitly investigated how the different parameters that define burst SCS may modulate its efficacy. The effectiveness of burst SCS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e6bc5a660ff7528ff488ec974446b9
https://doi.org/10.1111/ner.12221

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The role of spinal thrombin through protease-activated receptor 1 in hyperalgesia after neural injury

Autor: Jenell R. Smith, Beth A. Winkelstein

Publikováno v: Journal of neurosurgery. Spine. 26(4)

OBJECTIVE Painful neuropathic injuries induce blood–spinal cord barrier (BSCB) breakdown, allowing pro-inflammatory serum molecules to cross the BSCB, which contributes to nociception. The goal of these studies was to determine whether the blood-bo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::976cd6f4012303d68047d20a548078ed
https://pubmed.ncbi.nlm.nih.gov/28059686

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Effect of the Ligand in Atom Transfer Radical Polymerization Reactions Initiated by Photodimers of 9-Bromoanthracene

Autor: William T. Eckenhoff, Jenell R. Smith, Sona Thakur, Nicole A. Cohen, Tomislav Pintauer, Eric S. Tillman

Publikováno v: Macromolecular Chemistry and Physics. 210:263-268

Slow initiation from the bridgehead radical in atom transfer radical polymerization (ATRP) reactions initiated by 9-bromoanthracene photodimers leads to polymers' products possessing high PDI values and higher than expected M n values. We report here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::205b3ed10b143d67ee7986824d55741b
https://doi.org/10.1002/macp.200800481

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9-Bromoanthracene photodimers as initiators in controlled radical polymerization: Silane radical atom abstraction coupled with nitroxide mediated polymerization

Autor: Nathan D. Contrella, Jenell R. Smith, Sona Thakur, Nicole A. Cohen, Eric S. Tillman

Publikováno v: Journal of Polymer Science Part A: Polymer Chemistry. 46:6016-6022

Slow initiation relative to propagation has previously prevented photo-dimers of 9-bromoanthracene or 9-chloroanthracene, formed by [4 + 4] photocyclization reactions of the analogous 9-haloanthracene, from being viable initiators in atom transfer ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::151d17cb8b2b184c913fe5aa3aba3fa9
https://doi.org/10.1002/pola.22903

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