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LB1580. Efficacy Assessment of MAT2203 Encochleated Oral Formulation of Amphotericin B, in the Neutropenic Mouse Model of Pulmonary Mucormycosis

Autor: Teclegiorgis Gebremariam, Yiyou Gu, Sondus Alkhazraji, Eman Youssef, Theresa Matkovits, Jenel Cobb, Raphael J Mannino, Ashraf S Ibrahim

Publikováno v: Open Forum Infectious Diseases. 9

Background Invasive mucormycosis (IM) is associated with high mortality and morbidity. MAT2203 is an encochleated oral formulation of amphotericin B which has been shown to be safe and effective against murine aspergillosis and murine cryptococcal me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::016352e6f5209d0497bb4e825dc52b58
https://doi.org/10.1093/ofid/ofac492.1890

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Palmitoylation controls the dynamics of budding-yeast heterochromatin via the telomere-binding protein Rif1

Autor: Marc R. Gartenberg, Catherine A. Fox, Sookhee Park, Jenel Cobb, Erin Patterson, Anjon Audhya

Publikováno v: Proceedings of the National Academy of Sciences. 108:14572-14577

The posttranslational addition of palmitate to cysteines occurs ubiquitously in eukaryotic cells, where it functions in anchoring target proteins to membranes and in vesicular trafficking. Here we show that the Saccharomyces cerevisiae palmitoyltrans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::293357537116b53d158efa96724fd536
https://doi.org/10.1073/pnas.1105262108

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Abstract 3838: NKP-2235 exhibits a novel pattern of cytotoxicity with synergism across a broad range of antitumor agents demonstrated in multiple tumor types

Autor: Jenel Cobb, Angela Ogden, Rebecca Baerga, Hooshmand Sheshbaradaran

Publikováno v: Cancer Research. 72:3838-3838

Background: NKP-2235 is a first-in-class, orally bioavailable gallium based anti-cancer compound. The intracellular targets for NKP-2235 include the endoplasmic reticulum (ER). NKP-2235 treatment of tumor cells causes ER stress, intracellular Ca2+ re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::89d20422528194b68cebcaffa500337f
https://doi.org/10.1158/1538-7445.am2012-3838

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Abstract B223: NKP-1339 synergistic activity in both in vitro and in vivo preclinical models highlights the therapeutic opportunity for NKP-1339 combination trials with a broad range of antitumor agents

Autor: Hooshmand Sheshbaradaran, Angela Ogden, Rebecca Baerga, Jenel Cobb

Publikováno v: Molecular Cancer Therapeutics. 10:B223-B223

Background: NKP-1339 is a novel transferrin targeted ruthenium based compound that has shown promising single agent anti-cancer activity in preclinical models and in man. The compound has a novel mechanism of action, with GRP78 down-regulation includ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4062b961f39d9b9a72cbfb369221015c
https://doi.org/10.1158/1535-7163.targ-11-b223

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