Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jendrik, Schöppe"'
Autor:
Sille Remm, Dario De Vecchis, Jendrik Schöppe, Cedric A. J. Hutter, Imre Gonda, Michael Hohl, Simon Newstead, Lars V. Schäfer, Markus A. Seeger
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Mycobacterium tuberculosis is protected from antibiotic therapy by a multi-layered hydrophobic cell envelope. Major facilitator superfamily (MFS) transporter Rv1410 and the periplasmic lipoprotein LprG are involved in transport of triacylgly
Externí odkaz:
https://doaj.org/article/1960b492e8a54571b9bda14e84f5dd05
Autor:
Jendrik Schöppe, Janosch Ehrenmann, Christoph Klenk, Prakash Rucktooa, Marco Schütz, Andrew S. Doré, Andreas Plückthun
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Neurokinin receptors are G protein-coupled receptors. Here the authors present three crystal structures of the neurokinin 1 receptor (NK1R) in complex with small-molecule antagonists including aprepitant and netupitant and observe that these clinical
Externí odkaz:
https://doaj.org/article/6c1b5d05ad4143f2afd6b9134b37d802
Autor:
Cristian, Thom, Janosch, Ehrenmann, Santiago, Vacca, Yann, Waltenspühl, Jendrik, Schöppe, Ohad, Medalia, Andreas, Plückthun
Publikováno v:
Science Advances
Description
Neuropeptide-bound NK1R:G protein complex structures explain mechanisms ranging from insurmountable antagonism to activation.
The neurokinin 1 receptor (NK1R) is involved in inflammation and pain transmission. This pathophysiolo
Neuropeptide-bound NK1R:G protein complex structures explain mechanisms ranging from insurmountable antagonism to activation.
The neurokinin 1 receptor (NK1R) is involved in inflammation and pain transmission. This pathophysiolo
Publikováno v:
Science Advances
Human oxytocin receptor structure reveals the basis for ligand recognition and allosteric modulation by lipids and ions.
The peptide hormone oxytocin modulates socioemotional behavior and sexual reproduction via the centrally expressed oxytocin
The peptide hormone oxytocin modulates socioemotional behavior and sexual reproduction via the centrally expressed oxytocin
The parathyroid hormone 1 receptor (PTH1R) is a major regulator of mineral ion homeostasis and bone metabolism and is thus considered an attractive drug target for the treatment of disorders in calcium metabolism and bone-related diseases such as ost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f8e36bbdc07cc8bc225e5b6dd476ed0
https://doi.org/10.5167/uzh-181173
https://doi.org/10.5167/uzh-181173
Autor:
Prakash Rucktooa, Janosch Ehrenmann, Jendrik Schöppe, Marco Schütz, Christoph Klenk, Andrew S. Doré, Andreas Plückthun
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications
Nature Communications
Neurokinins (or tachykinins) are peptides that modulate a wide variety of human physiology through the neurokinin G protein-coupled receptor family, implicated in a diverse array of pathological processes. Here we report high-resolution crystal struc
Publikováno v:
Journal of Molecular Biology. 426:691-721
Antibodies are the most versatile binding proteins in nature with six loops creating a flexible continuous interaction surface. However, in some molecular formats, antibodies are aggregation prone. Designed ankyrin repeat proteins (DARPins) were succ
Publikováno v:
Journal of Molecular Biology
BCL-W is a member of the BCL-2 family of anti-apoptotic proteins. A key event in the regulation of apoptosis is the heterodimerization between anti-apoptotic and pro-apoptotic family members, which involves a conserved surface-exposed groove on the a
Autor:
Pascal Egloff, Christoph Klenk, Lutz Kummer, Jendrik Schöppe, Andreas Plückthun, Erik Sedlák, Matthias Hillenbrand, Janosch Ehrenmann, Gabriela Nagy-Davidescu, Marco Schütz
Publikováno v:
Scientific Reports
Despite recent successes, many G protein-coupled receptors (GPCRs) remained refractory to detailed molecular studies due to insufficient production yields, even in the most sophisticated eukaryotic expression systems. Here we introduce a robust metho
Autor:
Alexander Batyuk, Renato Zenobi, Yufan Wu, Basri Gülbakan, Lutz Kummer, Christoph Klenk, K. Dane Wittrup, Peer R. E. Mittl, Seymour de Picciotto, Erik Sedlák, Andreas Plückthun, Franziska Zosel, Jendrik Schöppe, Marco Schütz, Gregory A. Newby
Publikováno v:
Journal of Molecular Biology
Fluorescent probes constitute a valuable toolbox to address a variety of biological questions and they have become irreplaceable for imaging methods. Commonly, such probes consist of fluorescent proteins or small organic fluorophores coupled to biolo