Melanogenesis Inhibitors from the Rhizoma of Ligusticum Sinense in B16-F10 Melanoma Cells In Vitro and Zebrafish In Vivo

Autor: Yi Tzu Chu, Li Ling Syu, Su Jung Hsu, Min Chi Cheng, Jender Wu, Ching Kuo Lee, Tzong-Huei Lee, Chia Hsiung Cheng

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 19, Iss 12, p 3994 (2018)
Volume 19
Issue 12

The rhizoma of Ligusticum sinense, a Chinese medicinal plant, has long been used as a cosmetic for the whitening and hydrating of the skin in ancient China. In order to investigate the antimelanogenic components of the rhizoma of L. sinense, we perfo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f36cd7921b60f07ed8eb82a5662ba7a6
https://pubmed.ncbi.nlm.nih.gov/30545008

Vitamin K3-2,3-epoxide induction of apoptosis with activation of ROS-dependent ERK and JNK protein phosphorylation in human glioma cells

Autor: Liang Yo Yang, Guan Cheng Huang, Shing Chuan Shen, Yen Chou Chen, Chih Chiang Chien, Min Chi Cheng, Jender Wu, Che Tong Lin

Publikováno v: Chemico-Biological Interactions. 193:3-11

2-Methyl-1,4-naphthoquinone (menadione or vitamin K3; EPO) and K3-2,3-epoxide (EPO1), but not vitamin K3-3-OH (EPO2), exhibited cytotoxicity that caused DNA fragmentation and chromatin condensation in U87 and C6 cells. EPO1 showed more-potent cytotox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b56ab06eea7df20dd37fcf93f9f47da
https://doi.org/10.1016/j.cbi.2011.03.008

Anti-angiogenic action of 5,5-diphenyl-2-thiohydantoin-N10 (DPTH-N10)

Autor: Jender Wu, Pei-Yin Ho, Wen Sen Lee, Yu Chih Liang, Yuan Liu, Li Ching Chen, Cheng Kuo Cheng, Chiung-Tong Chen

Publikováno v: Cancer Letters. 271:294-305

Previously, we demonstrated that 5,5-diphenyl-2-thiohydantoin (DPTH) exerts an anti-proliferation effect on subcultured human umbilical vein endothelial cells (HUVEC). In the present study, we show that 2(naphthalen-2-ylmethylsulfanyl)-5,5-diphenyl-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd5fa63f11d6a528801ecda9b4e679c4
https://doi.org/10.1016/j.canlet.2008.06.016

Photolysis of NSAIDs. Part 3: Structural elucidation of photoproducts of tolmetin in methanol

Autor: Jender Wu, Ming Thau Sheu, An Bang Wu, Chih Jui Chen, Su Hui Chao

Publikováno v: Tetrahedron Letters. 45:8107-8109

A sample of 10 mM tolmetin in methanol was photo-irradiated with a Hanovia 200 W high-pressure quartz Hg lamp for four days. In total, eight photoproducts were observed from the HPLC chromatogram. Three major photoproducts were separated, and their s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f657df0b17c2d7ef6ac5794aebf1428c
https://doi.org/10.1016/j.tetlet.2004.08.177

Anti-proliferation effect of 5,5-diphenyl-2-thiohydantoin (DPTH) in human vascular endothelial cells

Autor: Ming Thau Sheu, Yuan Liu, Jender Wu, Chun Ru Shih, Yu Chih Liang, Wen Sen Lee, Shyr Yi Lin

Publikováno v: Biochemical pharmacology. 67(1)

The aim of this study was to examine the anti-proliferation effect of 5,5-diphenyl-2-thiohydantoin (DPTH), an analogue of antiepileptic drug phenytoin (5,5-diphenylhydantoin), on human umbilical vein endothelial cells (HUVEC) and its possible molecul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f4a66962cf8930309409ed34e3cc78b
https://pubmed.ncbi.nlm.nih.gov/14667929