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pro vyhledávání: '"Jena Fediuk"'
Autor:
Jena Fediuk, Shyamala Dakshinamurti
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 93:185-194
Persistent pulmonary hypertension of the newborn (PPHN) is defined as the failure of normal pulmonary vascular relaxation at birth. Hypoxia is known to impede postnatal disassembly of the actin cytoskeleton in pulmonary arterial myocytes, resulting i
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 302:L13-L26
Actin polymerization (APM), regulated by Rho GTPases, promotes myocyte force generation. Hypoxia is known to impede postnatal disassembly of the actin cytoskeleton in pulmonary arterial (PA) myocytes. We compared basal and agonist-induced APM in myoc
Publikováno v:
Fibrogenesis & Tissue Repair
Background Persistent pulmonary hypertension of the newborn (PPHN) is characterized by vasoconstriction and pulmonary vascular remodeling. Remodeling is believed to be a response to physical or chemical stimuli including pro-mitotic inflammatory medi
Publikováno v:
Pediatric Pulmonology. 46:1194-1208
Rationale Neonatal pulmonary hypertension is characterized by hypoxia, abnormal vascular remodeling, and impaired alveolarization. Nitric oxide (NO) regulates cell replication and activation of apoptosis. Our objective was to examine cell phenotype-s
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 307(11)
In hypoxic pulmonary arterial (PA) myocytes, challenge with thromboxane mimetic U46619 induces marked actin polymerization and contraction, phenotypic features of persistent pulmonary hypertension of the newborn (PPHN). Rho GTPases regulate the actin
Autor:
Martha Hinton, P.P. Lizotte, Jena Fediuk, Shyamala Dakshinamurti, Nora Nolette, Anurag Singh Sikarwar
Publikováno v:
Pulmonary pharmacologytherapeutics. 30
Persistent Pulmonary Hypertension of the Newborn (PPHN) is characterized by sustained vasospasm and an increased thromboxane:prostacyclin ratio. Thromboxane (TP) receptors signal via Gαq to mobilize IP 3 and Ca 2+ , causing pulmonary arterial constr
Autor:
Jena Fediuk, Shyamala Dakshinamurti
Publikováno v:
D63. SIGNAL TRANSDUCTION: MEMBRANE RECEPTORS AND INTRACELLULAR PATHWAYS.
Publikováno v:
Free radical biologymedicine. 48(7)
8-Isoprostane, a ROS-derived prostanoid that acts via the thromboxane receptor (TP), is implicated in neonatal pulmonary hypertension. The purpose of this study was to examine the effect of hypoxia on vascular smooth muscle ROS generation, 8-isoprost