Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jena B Goodman"'
Autor:
Yuxiang Zhou, Xueping Wan, Kerstin Seidel, Mo Zhang, Jena B. Goodman, Francesca Seta, Naomi Hamburg, Jingyan Han
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 18 (2021)
Background Persistent activation of endoplasmic reticulum stress and the unfolded protein response (UPR) induces vascular cell apoptosis, contributing to atherogenesis. Aging and hypercholesterolemia are 2 independent proatherogenic factors. How they
Externí odkaz:
https://doaj.org/article/7b7730c287e648edad5d66189bb73eea
Autor:
Xiaoyong Tong, Marcello Panagia, Fuzhong Qin, Deborah A. Siwik, Jena B Goodman, Dominique Croteau, David R. Pimentel, Richard A. Cohen, Ion A. Hobai, Ivan Luptak, Markus Bachschmid, Wilson S. Colucci, Robert J. Morgan, Jordan M. Chambers
Publikováno v:
Circulation. 142:2459-2469
Background: SERCA [sarco(endo)plasmic reticulum calcium ATPase] is regulated by oxidative posttranslational modifications at cysteine 674 (C674). Because sarcoplasmic reticulum (SR) calcium has been shown to play a critical role in mediating mitochon
Publikováno v:
Organelle and Molecular Targeting ISBN: 9781003092773
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c8d2a735a4ee3aa56c1b24e41bfe705
https://doi.org/10.1201/9781003092773-9
https://doi.org/10.1201/9781003092773-9
Autor:
Jingyan Han, Xueping Wan, Kerstin Seidel, Mo Zhang, Francesca Seta, Naomi M. Hamburg, Jena B Goodman, Yuxiang Zhou
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 18 (2021)
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 18 (2021)
Background Persistent activation of endoplasmic reticulum stress and the unfolded protein response (UPR) induces vascular cell apoptosis, contributing to atherogenesis. Aging and hypercholesterolemia are 2 independent proatherogenic factors. How they
Autor:
Dorina Avram, Jeff Arni Valisno, Eric Y. Helm, Francesca Seta, Lisia Venegas, Joel May, Enkhjargal Budbazar, Christopher J. Nicholson, Richard A. Cohen, Kathleen G. Morgan, Gary F. Mitchell, Kuldeep Singh, Jena B Goodman
Publikováno v:
Circulation research. 128(6)
Rationale: BCL11B (B-cell leukemia 11b) is a transcription factor known as an essential regulator of T lymphocytes and neuronal development during embryogenesis. A genome-wide association study showed that a gene desert region downstream of BCL11B ,
Autor:
Wilson S. Colucci, Jordan M. Chambers, David R. Pimentel, Deborah A. Siwik, Ivan Luptak, Fuzhong Qin, Ion A. Hobai, Jena B Goodman, Marcello Panagia, Dominique Croteau
Publikováno v:
Circulation. 142
Background: Inhibitors of sodium glucose linked transporter 2 (SGLT2i) improve heart failure (HF) outcomes in patients independent of diabetes. While animal studies suggest SGLT2i improve cardiac metabolism, the effect of SGLT2i on mitochondrial func
Autor:
Willem J. Laursen, Vincent P. Schulz, Owen H. Funk, Patrick G. Gallagher, Sviatoslav N. Bagriantsev, Elena O. Gracheva, Marco Mastrotto, Eve R. Schneider, Jena B. Goodman
Publikováno v:
Proceedings of the National Academy of Sciences. 111:14941-14946
Relying almost exclusively on their acute sense of touch, tactile-foraging birds can feed in murky water, but the cellular mechanism is unknown. Mechanical stimuli activate specialized cutaneous end organs in the bill, innervated by trigeminal affere
Autor:
Wilson S. Colucci, Ivan Luptak, Dominique Croteau, Michael T. Kirber, Deborah A. Siwik, Jena B Goodman, David R. Pimentel
Publikováno v:
Free Radical Biology and Medicine. 128:S27
Background Although sarco-endoplasmic reticulum ATPase-2 (SERCA) is located in close proximity to mitochondria, its role in the regulation of mitochondrial calcium ([Ca2+]m) is not clear. Reactive oxygen species (ROS) such as H2O2 can oxidize SERCA a
Autor:
Jin Sub Kim, Wilson S. Colucci, Jihua Tian, David R. Pimentel, Andreia Biolo, Richard A. Cohen, Cao Gao, Jena B Goodman, Deborah A. Siwik, Reiko Matsui, Fuzhong Qin
Publikováno v:
Free Radical Biology and Medicine. 128:S38
Background Glutaredoxin 1 (Grx1), an antioxidant enzyme, plays an important role in protecting cells from oxidative stress and apoptosis, events associated with myocardial remodeling and failure. Transgenic mice with cardiac-specific overexpression o
Autor:
Dana K. Merriman, Willem J. Laursen, Sviatoslav N. Bagriantsev, Owen H. Funk, Dominik Pesta, Jena B. Goodman, Marco Mastrotto, Elena O. Gracheva, Nicholas T. Ingolia, Gerald I. Shulman
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 112, iss 5
Hibernating mammals possess a unique ability to reduce their body temperature to ambient levels, which can be as low as −2.9 °C, by active down-regulation of metabolism. Despite such a depressed physiologic phenotype, hibernators still maintain ac