Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Jen-Shin Song"'
Autor:
Kai-Chia Yeh, Chia-Jui Lee, Jen-Shin Song, Chien-Huang Wu, Teng-Kuang Yeh, Szu-Huei Wu, Tsung-Chin Hsieh, Yen-Ting Chen, Huan-Yi Tseng, Chen-Lung Huang, Chiung-Tong Chen, Jiing-Jyh Jan, Ming-Chen Chou, Kak-Shan Shia, Kuang-Hsing Chiang
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11730 (2022)
CXCR4 antagonists have been claimed to reduce mortality after myocardial infarction in myocardial infarction (MI) animals, presumably due to suppressing inflammatory responses caused by myocardial ischemia-reperfusion injury, thus, subsequently facil
Externí odkaz:
https://doaj.org/article/6648043bcf8f4c41b33a71838ae4c3ac
Autor:
Seong-Jin Yu, Kuo-Jen Wu, Yu-Syuan Wang, Jen-Shin Song, Chien-Huang Wu, Jiing-Jyh Jan, Eunkyung Bae, Hsi Chen, Kak-Shan Shia, Yun Wang
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 19, p 7085 (2020)
Intracerebral hemorrhage (ICH) is a major cause of stroke, with high mortality and morbidity. There is no effective pharmacological therapy for ICH. Previous studies have indicated that CXCR4 antagonists reduced microglia activation, attenuated infil
Externí odkaz:
https://doaj.org/article/8f490ee12d3d48e196464454d22b9bba
Autor:
Kuo-Jen Wu, Seong-Jin Yu, Kak-Shan Shia, Chien-Huang Wu, Jen-Shin Song, Hsuan-Hao Kuan, Kai-Chia Yeh, Chiung-Tong Chen, Eunkyune Bae, Yun Wang M.D., Ph.D.
Publikováno v:
Cell Transplantation, Vol 26 (2017)
C-X-C chemokine receptor type 4 (CXCR4) is a receptor for a pleiotropic chemokine CXCL12. Previous studies have shown that the acute administration of the CXCR4 antagonist AMD3100 reduced neuroinflammation in stroke brain and mobilized bone marrow he
Externí odkaz:
https://doaj.org/article/5de1b142344f431aba5a4763c0f0da4d
Autor:
Yi-Fan Chen, Chien-Huang Wu, Li-Hsien Chen, Hao-Wei Lee, Jinq-Chyi Lee, Teng-Kuang Yeh, Jang-Yang Chang, Ming-Chen Chou, Hui-Ling Wu, Yen-Po Lai, Jen-Shin Song, Kai-Chia Yeh, Chiung-Tong Chen, Chia-Jui Lee, Kak-Shan Shia, Meng-Ru Shen
Publikováno v:
Journal of Medicinal Chemistry. 65:4767-4782
Chemotherapy-induced neurotoxicity is a common adverse effect of cancer treatment. No medication has been shown to be effective in the prevention or treatment of chemotherapy-induced neurotoxicity. Using minoxidil as an initial template for structura
Design, synthesis, and anticancer evaluation of 1-benzo[1,3]dioxol-5-yl-3-N-fused heteroaryl indoles
Autor:
Chun-Hsu Yao, Mine-Hsine Wu, Po-Wei Chang, Szu-Huei Wu, Jen-Shin Song, Hsing-Hao Huang, Yu-Chun Chen, Jinq-Chyi Lee
Publikováno v:
Molecular Diversity.
Autor:
Ning Deng, Yun-Yun Wu, Yanan Feng, Wen-Chieh Hsieh, Jen-Shin Song, Yu-Shiuan Lin, Ya-Hsien Tseng, Wan-Jhu Liao, Yi-Fan Chu, Yu-Cheng Liu, En-Cheng Chang, Chia-Rung Liu, Sheh-Yi Sheu, Ming-Tsan Su, Hung-Chih Kuo, Stanley N. Cohen, Tzu-Hao Cheng
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Earlier work has shown that siRNA-mediated reduction of the SUPT4H or SUPT5H proteins, which interact to form the DSIF complex and facilitate transcript elongation by RNA polymerase II (RNAPII), can decrease expression of mutant gene alleles containi
Autor:
Mine-Hsine Wu, Chuan Shih, Yen-Ting Chen, Teng-Kuang Yeh, Ya-Hui Chi, Yan-Fu Chen, Jen-Shin Song, Ming-Chun Hung, Wan-Ping Wang, Jing-Ya Wang, Ching-Ping Chen, Jen-Yu Yeh, Yu-Chieh Su, Pei-Chen Wang, Yi-Yu Ke, Chia-Hua Tsai, Chiung-Tong Chen, Zhong-Wei Wu, Chun-Ping Chang, Wen-Hsing Lin
Publikováno v:
Journal of Medicinal Chemistry
The A-type Aurora kinase is upregulated in many human cancers, and it stabilizes MYC-family oncoproteins, which have long been considered an undruggable target. Here, we describe the design and synthesis of a series of pyrimidine-based derivatives ab
Autor:
Wen-Chi Hsiao, Kun-Yi Hsin, Zhong-Wei Wu, Jen-Shin Song, Yen-Nan Yeh, Yan-Fu Chen, Chia-Hua Tsai, Pei-Hsuan Chen, Kak-Shan Shia, Chun-Ping Chang, Ming-Shiu Hung
Publikováno v:
Bioorganic chemistry. 130
Cannabinoid receptor 1 (CB1) is a G protein-coupled receptor and a therapeutic target for metabolic disorders. Numerous CB1 antagonists have been developed, but their functional selectivities and bias towards G protein or β-arrestin signaling have n
Autor:
Mine-Hsine Wu, Chuan Shih, Hsiao-Fu Chang, Chun-Ping Chang, Lun K. Tsou, Shau-Hua Ueng, Shiu Hwa Yeh, Chiung-Tong Chen, Yi-Yu Ke, Jen-Shin Song, Sheng-Ren Chen
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Machine learning is a well-known approach for virtual screening. Recently, deep learning, a machine learning algorithm in artificial neural networks, has been applied to the advancement of precision medicine and drug discovery. In this study, we perf
Publikováno v:
Future Medicinal Chemistry. 12:183-192
Aim: Cancer is a major health burden and a leading cause of death worldwide. We sought to discover potential anticancer molecules with novel scaffold for further development of more active agents to address the issue. Methodology: A series of β-carb