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Akademický článek

TDP-43-stratified single-cell proteomics of postmortem human spinal motor neurons reveals protein dynamics in amyotrophic lateral sclerosis

Autor: Amanda J. Guise, Santosh A. Misal, Richard Carson, Jen-Hwa Chu, Hannah Boekweg, Daisha Van Der Watt, Nora C. Welsh, Thy Truong, Yiran Liang, Shanqin Xu, Gina Benedetto, Jake Gagnon, Samuel H. Payne, Edward D. Plowey, Ryan T. Kelly

Publikováno v: Cell Reports, Vol 43, Iss 1, Pp 113636- (2024)

Summary: A limitation of conventional bulk-tissue proteome studies in amyotrophic lateral sclerosis (ALS) is the confounding of motor neuron (MN) signals by admixed non-MN proteins. Here, we leverage laser capture microdissection and nanoPOTS single-

Externí odkaz: https://doaj.org/article/8a6acb1de53f412fbde8d06f4b44f6e9

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Akademický článek

Integrated molecular response of exposure to traffic-related pollutants in the US trucking industry

Autor: Douglas I. Walker, Jaime E. Hart, Chirag J. Patel, Ruthann Rudel, Jen-hwa Chu, Eric Garshick, Kurt D. Pennell, Francine Laden, Dean P. Jones

Publikováno v: Environment International, Vol 158, Iss , Pp 106957- (2022)

Exposure to traffic-related pollutants, including diesel exhaust, is associated with increased risk of cardiopulmonary disease and mortality; however, the precise biochemical pathways underlying these effects are not known. To investigate biological

Externí odkaz: https://doaj.org/article/da01ed5681c84f55b12c44e785f7b6af

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