Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Jen-Chih Hsieh"'
Autor:
Allen Oak, Chengxiang Fan, Ying Zheng, Arben Nace, Ruifeng Yang, Anisa Ray, Jen-Chih Hsieh, George Cotsarelis
Publikováno v:
Journal of Clinical and Translational Science, Vol 7, Pp 23-23 (2023)
OBJECTIVES/GOALS: Current clinical practice recommends occlusive dressings (e.g., film and hydrocolloid) for wounds with variable regenerative capacities. However, clinical evidence suggests that occlusion may hinder regeneration. Our objective was t
Externí odkaz:
https://doaj.org/article/09f704f26f234c21b0ff4d7917b80a2d
Publikováno v:
Methods Mol Biol
Methods in Molecular Biology ISBN: 9781493937844
Methods in Molecular Biology ISBN: 9781493937844
The hair follicle (HF) is a dynamic structure readily accessible within the skin, and contains various pools of stem cells that have a broad regenerative potential during normal homeostasis and in response to injury. Recent discoveries demonstrating
Autor:
Jen-Chih Hsieh, Janet K. Lighthouse, Thomas A. Rosenquist, Liqun Zhang, Bernadette C. Holdener
Publikováno v:
Developmental Dynamics. 240:577-588
Deletion of the Mesd gene region blocks gastrulation and mesoderm differentiation in mice. MESD is a chaperone for the Wnt co-receptors: low-density lipoprotein receptor-related protein (LRP) 5 and 6 (LRP5/6). We hypothesized that loss of Wnt signali
Autor:
Fatma O. Kok, Howard I. Sirotkin, Jen-Chih Hsieh, Emma C. Oster, Laura Mentzer, Clarissa A. Henry
Publikováno v:
Developmental Biology. 307(2):214-226
Somitogenesis is a highly controlled process that results in segmentation of the paraxial mesoderm. Notch pathway activity in the presomitic mesoderm is fundamental for management of synchronized gene expression which is necessary for regulation of s
Publikováno v:
Nature Neuroscience. 6:701-707
Dorsoventral patterning of the telencephalon is established early in forebrain development and underlies many of the regional subdivisions that are critical to the later organization of neural circuits in the cerebral cortex and basal ganglia. Sonic
Autor:
Kristen Brown, Thomas A. Rosenquist, Liqun Zhang, Charles DeRossi, Jen-Chih Hsieh, Lance Lee, Stephen Wefer, Mary E. Wines, Bernadette C. Holdener
Publikováno v:
Cell. 112:355-367
Specification of embryonic polarity and pattern formation in multicellular organisms requires inductive signals from neighboring cells. One approach toward understanding these interactions is to study mutations that disrupt development. Here, we demo
Autor:
Laurent Kodjabachian, Amir Rattner, Igor B. Dawid, Jen Chih Hsieh, Philip M. Smallwood, Jeremy Nathans, Martha L. Rebbert, Cindy Harryman Samos, Roel Nusse
Publikováno v:
Nature. 398:431-436
The Wnt proteins constitute a large family of extracellular signalling molecules that are found throughout the animal kingdom and are important for a wide variety of normal and pathological developmental processes1,2. Here we describe Wnt-inhibitory
Publikováno v:
Proceedings of the National Academy of Sciences. 96:3546-3551
Biochemical studies of Wnt signaling have been hampered by difficulties in obtaining large quantities of soluble, biologically active Wnt proteins. In this paper, we report the production in Drosophila S2 cells of biologically active Xenopus Wnt8 (XW
Autor:
Nancy A. Jenkins, Amir Rattner, Philip M. Smallwood, Jeremy Nathans, N. G. Copeland, Debra J. Gilbert, Jen Chih Hsieh
Publikováno v:
Proceedings of the National Academy of Sciences. 94:2859-2863
This paper describes the identification of a new family of mammalian genes that encode secreted proteins containing homology to the cysteine-rich ligand-binding domain found in the frizzled family of transmembrane receptors. The secreted frizzled-rel
Autor:
Jen Chih Hsieh, Purnima Bhanot, Cindy Harryman Samos, Jennifer P. Macke, Jeremy Nathans, Marcel Brink, Roel Nusse, Yanshu Wang, Deborah J. Andrew
Publikováno v:
Nature. 382:225-230
Receptors for Wingless and other signalling molecules of the Wnt gene family have yet to be identified. We show here that cultured Drosophila cells transfected with a novel member of the frizzled gene family in Drosophila, Dfz2, respond to added Wing