Zobrazeno 1 - 1
of 1
pro vyhledávání: '"Jen Workman"'
Autor:
Yue Peng, Hanqing Dong, Xin Chen, Arno G. Steinig, Darla Landfair, David Epstein, Ryan Schulz, Paula A. Tavares-Greco, Meizhong Jin, Andy Cooke, Jonathan A. Pachter, Jen Workman, Jennifer Kahler, Kathryn M. Stolz, Christine Mantis, Linda Crew, Ti Wang, Mark J. Mulvihill, Mridula Kadalbajoo, Jing Wang, Maryland Franklin, Caterina Ferraro, Robert A. Wild, Julie Kan, Prafulla C. Gokhale, Mark Albertella, Roy Turton, An-Hu Li, Mark Bittner, Andrew Kleinberg
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(15)
A series of novel 6-aminofuro[3,2-c]pyridines as kinase inhibitors is described, most notably, OSI-296 (6). We discuss our exploration of structure-activity relationships and optimization leading to OSI-296 and disclose its pharmacological activity a