Výsledky vyhledávání

Abstract I26: Investigating the immune microenvironment in mouse models of pancreatic cancer

Autor: Owen J. Sansom, Douglas Strathdee, Jen Morton, Saadia A. Karim, Laura Lapienyte, Karen Pickering

Publikováno v: Cancer Research. 79:I26-I26

Pancreatic cancer is predicted to become the second most common cause of cancer death in the Western world by ~2025. The focus of our research has been to better understand the disease and identify more effective and targeted therapies, in particular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::595431a3b780646b4363a40fdd54b179
https://doi.org/10.1158/1538-7445.panca19-i26

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Abstract 2751: Development of a specific Wee-1 inhibitor

Autor: Gary Nelson, Mandy Watson, Tilly Bingham, Andrew M. Scott, Tom Pesnot, Anthony Huxley, Jen Morton, Montserrat Shelbourne

Publikováno v: Cancer Research. 79:2751-2751

Somatic mutations in the TP53 gene are one of the most frequent alterations in human cancers. The resulting TP53-deficient cancer cells rely on WEE1 to trigger a G2/M arrest, which allows for DNA repair and survival. Inhibition of WEE1 has therefore

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a360b87a5ca55ded4272dc3cdeb2585
https://doi.org/10.1158/1538-7445.am2019-2751

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Abstract PR10: CXCR2 Inhibition Suppresses Metastasis and Improves the Response to Immunotherapy in Pancreatic Cancer

Autor: Owen J. Sansom, Colin W. Steele, Peter Bailey, Saadia A. Karim, Andrew V. Biankin, Simon T. Barry, Josh Leach, R.J.B. Nibbs, Jen Morton

Publikováno v: Cancer Research. 76:PR10-PR10

PDAC is predicted to become the second commonest cause of cancer death in the western world by 2030. Aggressive invasion and early metastases are characteristic of the disease, and even the few patients eligible for potentially curative resection ine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f9beb169c43548a21261f2f8badb47c5
https://doi.org/10.1158/1538-7445.panca16-pr10

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The integrin αvβ6 is a promising therapeutic target for treating PDAC

Autor: Owen J. Sansom, Jen Morton, Thomas J. Evans, Claire Reader, John Marshall, S. Vallath, Andrew V. Biankin, Hemant M. Kocher

Publikováno v: Pancreatology. 16:S6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2bdb7508ffcaccedf1cc1bbb0c7a8594
https://doi.org/10.1016/j.pan.2016.04.023

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The integrin αvβ6 is a promising target for the therapy of PDAC: toward phase I trials

Autor: Shelia M. Violette, Jen Morton, Paul H. Weinreb, Colin W. Steele, Simon T. Barry, Tim Meyer, Owen J. Sansom, James A. Davies, S. Vallath, John Marshall, Hemant M. Kocher, Aldo Scarpa

Publikováno v: Pancreatology. 14:e3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57e0381e4abd189a1d0f01e452d5f23a
https://doi.org/10.1016/j.pan.2014.03.012

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mTOR signaling is a promising therapeutic target in a subset of human pancreatic ductal adenocarcinomas

Autor: Owen J. Sansom, Colin J. McKay, Saadia A. Karim, Nigel B. Jamieson, D.C. Morran, Roger Carter, Thomas J. Evans, Jen Morton

Publikováno v: Pancreatology. 13:e8

s / Pancreatology 13 (2013) e1–e20 e8 University College London, Institute of Liver and Digestive Health, Royal Free Hospital Guy's and St Thomas’ NHS Foundation Trust, London, Department of Gastroenterology King's College London and King's Healt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::11aaadd719d0f06f73df7cdfad71bcea
https://doi.org/10.1016/j.pan.2012.12.025

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CXCR2 inhibition protects against chronic pancreatitis in a murine model

Autor: Colin J. McKay, Owen J. Sansom, Jen Morton, Thomas J. Evans, C.R. Carter, Colin W. Steele

Publikováno v: Pancreatology. 13:e5

s / Pancreatology 13 (2013) e1–e20 e5 Conclusion: Components of the metabolic syndrome, which are associated with insulin resistance, namely elevated diastolic blood pressure, elevated serum HbA1c and decreased serum HDL were positively associated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::095e2853be9d503415b27bae280017a1
https://doi.org/10.1016/j.pan.2012.12.016

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