Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Jemma R. Mayall"'
Autor:
Jay C. Horvat, Richard Y. Kim, Natasha Weaver, Christopher Augood, Alexandra C. Brown, Chantal Donovan, Pierrick Dupre, Lakshitha Gunawardhana, Jemma R. Mayall, Nicole G. Hansbro, Avril A. B. Robertson, Luke A. J. O’Neill, Matthew A. Cooper, Elizabeth G. Holliday, Philip M. Hansbro, Peter G. Gibson
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-14 (2023)
Abstract Background Increased airway NLRP3 inflammasome-mediated IL-1β responses may underpin severe neutrophilic asthma. However, whether increased inflammasome activation is unique to severe asthma, is a common feature of immune cells in all infla
Externí odkaz:
https://doaj.org/article/60288ffe24fd40148d0b5a1960f9d444
Autor:
Chantal Donovan, Richard Y Kim, Izabela Galvao, Andrew G Jarnicki, Alexandra C Brown, Bernadette Jones‐Freeman, Henry M Gomez, Ridhima Wadhwa, Elinor Hortle, Ranjith Jayaraman, Haroon Khan, Sophie Pickles, Priyanka Sahu, Vrushali Chimankar, Xiaofan Tu, Md Khadem Ali, Jemma R Mayall, Duc H Nguyen, Kurtis F Budden, Vinod Kumar, Kate Schroder, Avril AB Robertson, Matthew A Cooper, Peter AB Wark, Brian G Oliver, Jay C Horvat, Philip M Hansbro
Publikováno v:
Immunology & Cell Biology. 100:235-249
Increased inflammasome responses are strongly implicated in inflammatory diseases; however, their specific roles are incompletely understood. Therefore, we sought to examine the roles of nucleotide-binding oligomerization domain-like receptor (NLR) f
Autor:
Alyssa J. Lochrin, Richard Kim, Philip M. Hansbro, Maximilian Plank, Steven Maltby, Jemma R. Mayall, Kelly L. Asquith, Hock L. Tay, Paul S. Foster, Gabrielle T. Belz, Simon Keely, Jay C. Horvat, Jessica L. Barnes, Gerard E. Kaiko, Lorena R Sabino
Publikováno v:
Mucosal Immunology. 14:1077-1087
CD4+ T-helper 22 (Th22) cells are a phenotypically distinct lymphocyte subset that produces high levels of interleukin (IL)-22 without co-production of IL-17A. However, the developmental origin and lineage classification of Th22 cells, their interrel
Autor:
Philip M. Hansbro, Phillip Jobling, Jay C. Horvat, Dirk F. van Helden, Jemma R. Mayall, Anne Chevalier, Huw McCarthy, Jia Ming Lee
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 318:E981-E994
Chlamydia trachomatis infection is a primary cause of reproductive tract diseases including infertility. Previous studies showed that this infection alters physiological activities in mouse oviducts. Whether this occurs in the uterus and cervix has n
Autor:
James W. Pinkerton, Philip M. Hansbro, Debbie Trinder, Dikaia Xenaki, Theo Borghuis, Gang Liu, Bernadette Jones-Freeman, Ritambhara Aryal, Jay C. Horvat, Khadem Ali, Daniel M. Johnstone, Jemma R. Mayall, Brian G. Oliver, Richard Kim, Chantal Donovan, Kanth Swaroop Vanka, Janette K. Burgess, Amber L. Pillar, Kristy L. Martin, Alexandra C. Brown, R. Karim, Moones Heidari, Elizabeth A. Milward
Publikováno v:
JOURNAL OF PATHOLOGY, 251(1), 49-62. Wiley
Increased iron levels and dysregulated iron homeostasis, or both, occur in several lung diseases. Here, the effects of iron accumulation on the pathogenesis of pulmonary fibrosis and associated lung function decline was investigated using a combinati
Autor:
Bronwyn S. Berthon, Malcolm R. Starkey, Peter G. Gibson, Lisa Wood, James W. Pinkerton, Md. Khadem Ali, Hayley A. Scott, Jemma R. Mayall, Yike Guo, Katherine J. Baines, Mark E. Cooper, Chantal Donovan, Avril A. B. Robertson, Jay C. Horvat, Olivia R. Carroll, Brittany Rae, Alexandra C. Brown, Nazanin Zounemat Kermani, Ian M. Adcock, Luke A. J. O'Neill, Richard Kim, Philip M. Hansbro
Publikováno v:
The Journal of allergy and clinical immunology. 149(4)
Background Obesity is a risk factor for asthma, and obese asthmatic individuals are more likely to have severe, steroid-insensitive disease. How obesity affects the pathogenesis and severity of asthma is poorly understood. Roles for increased inflamm
Autor:
Jessica L, Barnes, Maximilian W, Plank, Kelly, Asquith, Steven, Maltby, Lorena R, Sabino, Gerard E, Kaiko, Alyssa, Lochrin, Jay C, Horvat, Jemma R, Mayall, Richard Y, Kim, Philip M, Hansbro, Simon, Keely, Gabrielle T, Belz, Hock L, Tay, Paul S, Foster
Publikováno v:
Mucosal immunology. 14(5)
CD4
Autor:
Jemma R. Mayall, Prabuddha S. Pathinayake, Guoqiang Wang, Jay C. Horvat, Fang Wang, Katie Daly, Philip M. Hansbro, Peter A. B. Wark, Andrew T. Reid, Alan C-Y. Hsu, Punnam Chander Veerati
SummarySARS-CoV-2 infection causes an inflammatory cytokine storm and acute lung injury. Currently there are no effective antiviral and/or anti-inflammatory therapies. Here we demonstrate that 2019 SARS-CoV-2 spike protein subunit 1 (CoV2-S1) induces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31e9ff3f4b7a81be0f3af753d958260b
https://doi.org/10.1101/2020.09.30.317818
https://doi.org/10.1101/2020.09.30.317818
Autor:
Jodie L. Simpson, Lisa Wood, Jay C. Horvat, M Khadem Ali, Katherine J. Baines, James W. Pinkerton, Jeremy A. Hirota, Mark E. Cooper, Malcolm R. Starkey, Peter G. Gibson, Darryl A. Knight, Avril A. B. Robertson, Philip M. Hansbro, Ama Tawiah Essilfie, Alexandra C. Brown, Peter A. B. Wark, Richard Kim, Jemma R. Mayall, Luke A. J. O'Neill, Nicole G. Hansbro
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 196:283-297
Rationale: Severe, steroid-resistant asthma is the major unmet need in asthma therapy. Disease heterogeneity and poor understanding of pathogenic mechanisms hampers the identification of therapeutic targets. Excessive nucleotide-binding oligomerizati
Autor:
Md. Khadem Ali, Brittany Rae, Richard Kim, Malcolm R. Starkey, Lisa Wood, Jay C. Horvat, Mark E. Cooper, Philip M. Hansbro, Avril A. B. Robertson, James W. Pinkerton, Jemma R. Mayall, Luke A. J. O'Neill, Alexandra C. Brown
Publikováno v:
Allergy and immunology.
Introduction: Severe, steroid-resistant (SSR) asthma is the major unmet need in asthma management and obese asthmatics are more likely to have therapy-resistant disease. Recent studies strongly implicate a role for NLRP3 inflammasome responses in dri