Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jemina Lehto"'
Autor:
Amineh Ghaderi, Mohammad-Ali Okhovat, Jemina Lehto, Luigi De Petris, Ehsan Manouchehri Doulabi, Parviz Kokhaei, Wen Zhong, Georgios Z. Rassidakis, Elias Drakos, Ali Moshfegh, Johan Schultz, Thomas Olin, Anders Österborg, Håkan Mellstedt, Mohammad Hojjat-Farsangi
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1148 (2023)
The ROR1 receptor tyrosine kinase is expressed in embryonic tissues but is absent in normal adult tissues. ROR1 is of importance in oncogenesis and is overexpressed in several cancers, such as NSCLC. In this study, we evaluated ROR1 expression in NSC
Externí odkaz:
https://doaj.org/article/1287c54575b8479d88d0bd97b869a154
Autor:
Nina M. S. Gustafsson, Katarina Färnegårdh, Nadilly Bonagas, Anna Huguet Ninou, Petra Groth, Elisee Wiita, Mattias Jönsson, Kenth Hallberg, Jemina Lehto, Rosa Pennisi, Jessica Martinsson, Carina Norström, Jessica Hollers, Johan Schultz, Martin Andersson, Natalia Markova, Petra Marttila, Baek Kim, Martin Norin, Thomas Olin, Thomas Helleday
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Targeting the glycolytic PFKFB3 enzyme is being studied as a therapeutic strategy against cancer. Here the authors identify PFKFB3 as being involved in homologous recombination (HR) repair of DNA double strand breaks (DSBs) and present a PFKFB3 inhib
Externí odkaz:
https://doaj.org/article/a5be37faa19d4d1fbbb9c428f096c524
Autor:
Otto Manninen, Tero Puolakkainen, Jemina Lehto, Elina Harittu, Aki Kallonen, Marko Peura, Tiina Laitala-Leinonen, Outi Kopra, Riku Kiviranta, Anna-Elina Lehesjoki
Publikováno v:
Bone Reports, Vol 3, Iss C, Pp 76-82 (2015)
Progressive myoclonus epilepsy of Unverricht–Lundborg type (EPM1) is an autosomal recessively inherited disorder characterized by incapacitating stimulus-sensitive myoclonus and tonic-clonic epileptic seizures with onset at the age of 6 to 16 years
Externí odkaz:
https://doaj.org/article/558bc8e1741246329c0a8edcf72ed2be
Soluble activin type IIB receptor improves fracture healing in a closed tibial fracture mouse model.
Autor:
Tero Puolakkainen, Petri Rummukainen, Jemina Lehto, Olli Ritvos, Ari Hiltunen, Anna-Marja Säämänen, Riku Kiviranta
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180593 (2017)
Fractures still present a significant burden to patients due to pain and periods of unproductivity. Numerous growth factors have been identified to regulate bone remodeling. However, to date, only the bone morphogenetic proteins (BMPs) are used to en
Externí odkaz:
https://doaj.org/article/a8a62e10a72b4721ae737530cfe4ed3e
Autor:
Jos Jonkers, Anna Huguet Ninou, Emma Åkerlund, Ulrika Joneborg, Dimitrios Chioureas, Joseph W. Carlson, Brinton Seashore-Ludlow, Hannah Stigsdotter, Korbinian Schelzig, Nina M. S. Gustafsson, Greta Gudoityte, Jemina Lehto
Publikováno v:
Cancers
Cancers, Vol 13, Iss 3604, p 3604 (2021)
Cancers; Volume 13; Issue 14; Pages: 3604
Cancers, Vol 13, Iss 3604, p 3604 (2021)
Cancers; Volume 13; Issue 14; Pages: 3604
Simple Summary DNA-damaging chemotherapeutics, such as platinum drugs, are cornerstones in cancer treatment. The efficacy of such treatment is intimately linked to the DNA repair capacity of the cancer cells, as DNA damage above a tolerable threshold
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0760a1448b21e23da4e0b92d08fb949e
http://europepmc.org/articles/PMC8306909
http://europepmc.org/articles/PMC8306909
Autor:
Fu-Ping Zhang, Anne Roivainen, Rana Al Majidi, Petri Rummukainen, Fan Wang, Tero Puolakkainen, Riku Kiviranta, Roland Baron, Outi Mäkitie, Jemina Lehto, Kati Tarkkonen, Kenichi Nagano, Vappu Nieminen-Pihala
Publikováno v:
Journal of Bone and Mineral Research
Human genetic evidence demonstrates that WNT1 mutations cause osteogenesis imperfecta (OI) and early‐onset osteoporosis, implicating WNT1 as a major regulator of bone metabolism. However, its main cellular source and mechanisms of action in bone re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c5d6e733a11a1ce086236dc718fbb15
https://doi.org/10.1002/jbmr.3680
https://doi.org/10.1002/jbmr.3680
Publikováno v:
Cancers
Volume 13
Issue 6
Cancers, Vol 13, Iss 1442, p 1442 (2021)
Volume 13
Issue 6
Cancers, Vol 13, Iss 1442, p 1442 (2021)
Simple Summary Chemotherapeutics exerting their antiproliferative actions by introducing DNA crosslinks, such as platinum drugs, are used to treat numerous cancers. Unfortunately, their therapeutic potential is limited due to adverse side effects and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c86cf73fa0b000013057a594cfdc7e54
Autor:
Aki Kallonen, Tiina Laitala-Leinonen, Anna-Elina Lehesjoki, Jemina Lehto, Tero Puolakkainen, Outi Kopra, Marko Peura, Riku Kiviranta, Elina Harittu, Otto Manninen
Publikováno v:
Bone Reports, Vol 3, Iss C, Pp 76-82 (2015)
Bone Reports
Bone Reports
Progressive myoclonus epilepsy of Unverricht–Lundborg type (EPM1) is an autosomal recessively inherited disorder characterized by incapacitating stimulus-sensitive myoclonus and tonic-clonic epileptic seizures with onset at the age of 6 to 16 years
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af85fdb8a8dcccd09e7a8c9487920fda
Autor:
Jessica Hollers, Martin Norin, Katarina Färnegårdh, Jemina Lehto, Nadilly Bonagas, N. Markova, Carina Norström, Anna Huguet Ninou, Petra Groth, Nina M. S. Gustafsson, Martin Andersson, Jessica Martinsson, Baek Kim, Elisee Wiita, Rosa Pennisi, Thomas Olin, Kenth Hallberg, Johan Schultz, Mattias Jönsson, Petra Marttila, Thomas Helleday
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications
Nature Communications
The glycolytic PFKFB3 enzyme is widely overexpressed in cancer cells and an emerging anti-cancer target. Here, we identify PFKFB3 as a critical factor in homologous recombination (HR) repair of DNA double-strand breaks. PFKFB3 rapidly relocates into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7ea467c334b76d93f503c7eee3f7fb8
Autor:
Riku Kiviranta, Ari Hiltunen, Petri Rummukainen, Jemina Lehto, Tero Puolakkainen, Olli Ritvos, Anna-Marja Säämänen
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 7, p e0180593 (2017)
PLoS ONE, Vol 12, Iss 7, p e0180593 (2017)
Fractures still present a significant burden to patients due to pain and periods of unproductivity. Numerous growth factors have been identified to regulate bone remodeling. However, to date, only the bone morphogenetic proteins (BMPs) are used to en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06cc1f581a44c6e710dae71124ceb7dd
https://doi.org/10.1371/journal.pone.0180593
https://doi.org/10.1371/journal.pone.0180593