Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jemima C. Thomas"'
Autor:
Catarina, Felisberto-Rodrigues, Jemima C, Thomas, Craig, McAndrew, Yann-Vaï, Le Bihan, Rosemary, Burke, Paul, Workman, Rob L M, van Montfort
Publikováno v:
The Biochemical journal. 476(18)
DHX8 is a crucial DEAH-box RNA helicase involved in splicing and required for the release of mature mRNA from the spliceosome. Here, we report the biochemical characterisation of full-length human DHX8 and the catalytically active helicase core DHX8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::41bcd5a281be34a40051114e9c7e2978
https://pubmed.ncbi.nlm.nih.gov/31409651
https://pubmed.ncbi.nlm.nih.gov/31409651
Publikováno v:
Biochemistry
Proteins of the ankyrin-repeat and SOCS-box (ASB) family act as the substrate-recognition subunits of ECS-type (ElonginBC-Cullin-SOCS-box) Cullin RING E3 ubiquitin ligase (CRL) complexes that catalyze the specific polyubiquitination of cellular prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2072623a06f3ca0cdd5ded525ff705
http://europepmc.org/articles/PMC3756526
http://europepmc.org/articles/PMC3756526
Autor:
Natasha S Clayton, Darerca Owen, Helen R. Mott, Chensu Wang, Michael A. White, Chris Abell, Jonathan M. Cooper, Jemima C. Thomas
Publikováno v:
Thomas, J C, Cooper, J M, Clayton, N S, Wang, C, White, M A, Abell, C, Owen, D & Mott, H R 2016, ' Inhibition of Ral GTPases Using a Stapled Peptide Approach ', Journal of Biological Chemistry, vol. 291, no. 35, pp. 18310-18325 . https://doi.org/10.1074/jbc.M116.720243
Aberrant Ras signaling drives numerous cancers, and drugs to inhibit this are urgently required. This compelling clinical need combined with recent innovations in drug discovery including the advent of biologic therapeutic agents, has propelled Ras b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56e69e1c709e2aeaa073e48964fc156d
https://pubmed.ncbi.nlm.nih.gov/27334922
https://pubmed.ncbi.nlm.nih.gov/27334922
Autor:
Jemima C. Thomas, Anthony A. Holder, Christopher H. Douse, Ernesto Cota, Edward W. Tate, Gordon Langsley, Paula S. Salgado, Peter Simpson, Judith L. Green
Publikováno v:
Journal of Biological Chemistry. 287:36968-36977
The interaction between the C-terminal tail of myosin A (MyoA) and its light chain, myosin A tail domain interacting protein (MTIP), is an essential feature of the conserved molecular machinery required for gliding motility and cell invasion by apico
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7371dcd0777b864c63b288b8262c18ca
https://doi.org/10.1074/jbc.m112.379842
https://doi.org/10.1074/jbc.m112.379842
Autor:
Christopher H, Douse, Sabrina J, Maas, Jemima C, Thomas, James A, Garnett, Yunyun, Sun, Ernesto, Cota, Edward W, Tate
Publikováno v:
ACS chemical biology. 9(10)
Constrained α-helical peptides are an exciting class of molecule designed to disrupt protein-protein interactions (PPIs) at a surface-exposed helix binding site. Complexes that engage more than one helical face account for over a third of structural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2645ab00ab96217e391eb2b3736a2298
https://pubmed.ncbi.nlm.nih.gov/25084543
https://pubmed.ncbi.nlm.nih.gov/25084543
Autor:
Peter Simpson, Anthony A. Holder, Stephen R. Martin, Judith L. Green, Ronald I. Howson, Jemima C. Thomas, Edward W. Tate, D.K. Moss, Ernesto Cota
Publikováno v:
Molecular bioSystems. 6(3)
The myosin tail domain interacting protein-myosin A (MTIP-MyoA) protein complex is an essential element of the motor driving invasion of red blood cells by the Plasmodium species that cause malaria. Here we report the key determinants of binding at t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b27fb9e676691c9e0049c36f94f487b
https://pubmed.ncbi.nlm.nih.gov/20174678
https://pubmed.ncbi.nlm.nih.gov/20174678