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Supplementary Figure S5 from Eradication of Canine Diffuse Large B-Cell Lymphoma in a Murine Xenograft Model with CD47 Blockade and Anti-CD20

Autor: Jaime F. Modiano, Irving L. Weissman, M. Gerard O'Sullivan, Timothy D. O'Brien, Ingrid Cornax, Kelly M. McKenna, Susan Prohaska, Amira Barkal, David Lowery, Sarah Rue, Jem Efe, Kristin Bloink, Aaron M. Ring, Hirotaka Tomiyasu, Peter J. Schnorr, Daisuke Ito, Katie L. Anderson, Kipp Weiskopf

1E4 antibody binds canine CD20 extracellular domain 2.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15c205800718db29fffa850b50309e0
https://doi.org/10.1158/2326-6066.22538005

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Supplementary Tables 1 through 3, Supplementary Figure Legends, and Supplementary Materials and Methods from Eradication of Canine Diffuse Large B-Cell Lymphoma in a Murine Xenograft Model with CD47 Blockade and Anti-CD20

Supplementary Table S1. Similarity between CD47 variants across species. Supplementary Table S2. Similarity between SIRPα variants across species. Supplementary Table S3. Summary of tumor necrosis scores following treatment with the indicated therap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0998af4d8c0fbbf81ba7e44f13fa3856
https://doi.org/10.1158/2326-6066.22537996

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Data from Eradication of Canine Diffuse Large B-Cell Lymphoma in a Murine Xenograft Model with CD47 Blockade and Anti-CD20

Cancer immunotherapies hold much promise, but their potential in veterinary settings has not yet been fully appreciated. Canine lymphomas are among the most common tumors of dogs and bear remarkable similarity to human disease. In this study, we exam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2fbff520e8497947a2d9e56f4f99586e
https://doi.org/10.1158/2326-6066.c.6548632.v1

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Supplementary Figure S4 from Eradication of Canine Diffuse Large B-Cell Lymphoma in a Murine Xenograft Model with CD47 Blockade and Anti-CD20

Canine macrophages respond to CD47-blocking therapies in vitro.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bfc4d55804acf5cd3200c298cb42f25
https://doi.org/10.1158/2326-6066.22538008

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Supplementary Figure S1 from Eradication of Canine Diffuse Large B-Cell Lymphoma in a Murine Xenograft Model with CD47 Blockade and Anti-CD20

Recombinant production and evaluation of canine SIRPalpha protein.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2702b4ee0a88d5c5e8b2837542c9060
https://doi.org/10.1158/2326-6066.22538017.v1

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Supplementary Figure S2 from Eradication of Canine Diffuse Large B-Cell Lymphoma in a Murine Xenograft Model with CD47 Blockade and Anti-CD20

CD47 expression on canine cancer samples.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::584447f37816612af6c3fde7668d3cd0
https://doi.org/10.1158/2326-6066.22538014.v1

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Supplementary Figure S6 from Eradication of Canine Diffuse Large B-Cell Lymphoma in a Murine Xenograft Model with CD47 Blockade and Anti-CD20

CV1 does not inhibit proliferation of CLBL-1 cells in vitro.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e283d095c71edc7f5040de93596062
https://doi.org/10.1158/2326-6066.22538002

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Supplementary Figure S3 from Eradication of Canine Diffuse Large B-Cell Lymphoma in a Murine Xenograft Model with CD47 Blockade and Anti-CD20

Microscopic visualization demonstrates macrophage engulfment of CLBL-1 cells.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c6f8434e8109bfe56da78060fea864
https://doi.org/10.1158/2326-6066.22538011

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Supplementary Figure S7 from Eradication of Canine Diffuse Large B-Cell Lymphoma in a Murine Xenograft Model with CD47 Blockade and Anti-CD20

Combination therapy with CD47-blockade and anti-CD20 antibodies produces in vivo efficacy with no overt toxicity.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::760bd84ee6aed6e5fc7e46380346bba4
https://doi.org/10.1158/2326-6066.22537999.v1

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