Zobrazeno 1 - 10 of 51 pro vyhledávání: '"Jelmar, Quist"'
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Akademický článek
Adipose-enriched peri-tumoral stroma, in contrast to myofibroblast-enriched stroma, prognosticates poorer survival in breast cancers
Autor: Hannah Si Hui Lau, Veronique Kiak Mien Tan, Benita Kiat Tee Tan, Yirong Sim, Jelmar Quist, Aye Aye Thike, Puay Hoon Tan, Shazib Pervaiz, Anita Grigoriadis, Kanaga Sabapathy
Publikováno v: npj Breast Cancer, Vol 9, Iss 1, Pp 1-14 (2023)
Abstract Despite our understanding of the genetic basis of intra-tumoral heterogeneity, the role of stromal heterogeneity arising from an altered tumor microenvironment in affecting tumorigenesis is poorly understood. In particular, extensive study o
Externí odkaz: https://doaj.org/article/482f96ed3bbe408b8d0cdb71f2bc3858
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2
Akademický článek
Systemic immune reaction in axillary lymph nodes adds to tumor-infiltrating lymphocytes in triple-negative breast cancer prognostication
Autor: Fangfang Liu, Thomas Hardiman, Kailiang Wu, Jelmar Quist, Patrycja Gazinska, Tony Ng, Arnie Purushotham, Roberto Salgado, Xiaojing Guo, Sarah E. Pinder, Anita Grigoriadis
Publikováno v: npj Breast Cancer, Vol 7, Iss 1, Pp 1-10 (2021)
Abstract The level of stromal tumor-infiltrating lymphocytes (sTILs) in triple-negative (TNBC) and HER2-positive breast cancers convey prognostic information. The importance of systemic immunity to local immunity is unknown in breast cancer. We previ
Externí odkaz: https://doaj.org/article/fa6779f79a31447c9a8b4c88579bba41
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3
Akademický článek
Integrated genomics and functional validation identifies malignant cell specific dependencies in triple negative breast cancer
Autor: Nirmesh Patel, Daniel Weekes, Konstantinos Drosopoulos, Patrycja Gazinska, Elodie Noel, Mamun Rashid, Hasan Mirza, Jelmar Quist, Fara Brasó-Maristany, Sumi Mathew, Riccardo Ferro, Ana Mendes Pereira, Cynthia Prince, Farzana Noor, Erika Francesch-Domenech, Rebecca Marlow, Emanuele de Rinaldis, Anita Grigoriadis, Spiros Linardopoulos, Pierfrancesco Marra, Andrew N. J. Tutt
Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Triple negative breast cancers harbor multiple copy number aberrations driving gene expression changes thought to underpin their malignant phenotypes. Here the authors integrate these features, finding and functionally validating 37 gene addictions a
Externí odkaz: https://doaj.org/article/5040e6ddb1d140d09e37fbc06a8ca400
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5
Supplementary Tables S16-S20 from A Four-gene Decision Tree Signature Classification of Triple-negative Breast Cancer: Implications for Targeted Therapeutics
Autor: Anita Grigoriadis, Andrew N.J. Tutt, Christopher J. Lord, Joyce A. O'Shaughnessy, Melinda L. Telli, Maggie C.U. Cheang, Hasan Mirza, Jelmar Quist
Supplementary Table S16: Results from the gene set enrichment analysis of 28 different immune signatures across the METABRIC-set 15 (MC subtypes) classification. Supplementary Table S17: Table representing the copy number status of the five genes par
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8811b32e022204dcee31f4820b470151
https://doi.org/10.1158/1535-7163.22504419.v1
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7
Data from A Four-gene Decision Tree Signature Classification of Triple-negative Breast Cancer: Implications for Targeted Therapeutics
Autor: Anita Grigoriadis, Andrew N.J. Tutt, Christopher J. Lord, Joyce A. O'Shaughnessy, Melinda L. Telli, Maggie C.U. Cheang, Hasan Mirza, Jelmar Quist
The molecular complexity of triple-negative breast cancers (TNBCs) provides a challenge for patient management. We set out to characterize this heterogeneous disease by combining transcriptomics and genomics data, with the aim of revealing convergent
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0c8d4f900299dd7ce66676144de8daa
https://doi.org/10.1158/1535-7163.c.6537732
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