Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jelle Thole"'
Autor:
Stefan H. E. Kaufmann, Hazel M. Dockrell, Nick Drager, Mei Mei Ho, Helen McShane, Olivier Neyrolles, Tom H. M. Ottenhoff, Brij Patel, Danielle Roordink, François Spertini, Steffen Stenger, Jelle Thole, Frank A. W. Verreck, Ann Williams, TBVAC2020 Consortium, Warwick Britton, Jamie Triccas, Claudio Counoupas, Johan Grooten, Marie-Ange Demoitie, Marta Romano, Francoise Mascart, Peter Andersen, Claus Aagaard, Dennis Christensen, Morten Ruhwald, Thomas Lindenstrom, Pierre Charneau, Christophe Guilhot, Antonio Peixoto, Martine Gilleron, Camille Locht, Roland Brosch, Genevieve Inchauspe, Stephane Leung Theung Long, Stefan Kaufmann, January Weiner, Jeroen Maertzdorf, Natalie Neuwenhuizen, Max Bastian, Nadia Caccamo, Delia Goletti, Roberto Nisini, Sung Jae Shin, Hyejon Lee, Alex Sigal, Thomas Scriba, Gerhard Walzl, Andre Loxton, Robert Wilkinson, Pere-Joan Cardona, Cris Vilaplana, Carlos Martin, Dessi Marinova, Nacho Aguilo, Ruedi Aebersold, Etienne Caron, Daniel Pinschewer, Gennaro De Libero, Claire Anne Siegrist, Nicolas Collin, Christophe Barnier-Quer, Peter Sander, Frank Verreck, Tom Ottenhoff, Simone Joosten, Krista van Meijgaarden, Mariateresa Coppola, Annemieke Geluk, Yvonne Perrie, Marc Baird, Michael Levin, Hazel Dockrell, Steven Smith, Helen Fletcher, Gregory Bancroft, Ann Rawkins, Simon Clark, Iman Satti, Elena Stylianou, Martin Vordermeier, Philip Hogarth
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
TBVAC2020 is a research project supported by the Horizon 2020 program of the European Commission (EC). It aims at the discovery and development of novel tuberculosis (TB) vaccines from preclinical research projects to early clinical assessment. The p
Externí odkaz:
https://doaj.org/article/c7965df9c6da40b7adb41882e3834949
Autor:
Jesús Gonzalo-Asensio, Serge Mostowy, Jose Harders-Westerveen, Kris Huygen, Rogelio Hernández-Pando, Jelle Thole, Marcel Behr, Brigitte Gicquel, Carlos Martín
Publikováno v:
PLoS ONE, Vol 3, Iss 10, p e3496 (2008)
Inactivation of the transcriptional regulator PhoP results in Mycobacterium tuberculosis attenuation. Preclinical testing has shown that attenuated M. tuberculosis phoP mutants hold promise as safe and effective live vaccine candidates. We focused th
Externí odkaz:
https://doaj.org/article/acf078ffa7584179b0b1223916c2ab17
Autor:
Dominick Laddy, Gerald Voss, Dereck Tait, Ilona van den Brink, Marit Holleman, Maria Lempicki, Danielle Roordink, Leo van der Pol, Ann Williams, Anne Marie Graffin, Emmanuelle Gerdil, Jelle Thole, Bernard Fritzell, Georges Thiry
Publikováno v:
Tuberculosis (Edinburgh, Scotland)
Two proof of concept clinical trials with TB vaccines demonstrate that new approaches can prevent sustained TB infection in adolescents (BCG revaccination) and TB disease in adults (M72/ASO1E) (Nemes et al., 2018; Tait et al., 2019) [1,2]. Both appro
Autor:
Xoliswa Kalepu, Lebohang Makhethe, Simbarashe Mabwe, Tim Reid, Susan Rossouw, Petrus Tyambethu, Juana Doce, Fazlin Kafaar, Adam Penn-Nicholson, Nondumiso Khomba, Lungisa Jack, Helen Mearns, Nicole Bilek, Angelique Kany Kany Luabeya, Yolande Gregg, Ingrid Murillo, Elma Van Rooyen, Julia Noble, Erica Smit, Constance Schreuder, Nacho Aguilo, Michele Tameris, Jesús Gonzalo-Asensio, Humphrey Mulenga, Munyaradzi Musvosvi, Yolundi Cloete, Natasja Botes, Esteban M. Rodríguez, Hadn Africa, Bernard Fritzell, Jelle Thole, Mark Hatherill, Thomas J. Scriba, Eugenia Puentes, Margaret Erasmus, Ashley Veldsman, Marwou de Kock, Angelique Mouton, Hennie Geldenhuys, Sandra Kruger, Fajwa Opperman, Justin Shenje, Marcia Steyn, Carlos Martin, Denis Arendsen, Dessislava Marinova, Thelma Leopeng
Publikováno v:
The Lancet. Respiratory medicine. 7(9)
Summary Background Infants are a key target population for new tuberculosis vaccines. We assessed the safety and immunogenicity of the live-attenuated Mycobacterium tuberculosis vaccine candidate MTBVAC in adults and infants in a region where transmi
Autor:
Sam O. Hofman, Eugenia Puentes, Clemens H. M. Kocken, Joost H.A. Martens, Nacho Aguilo, Frank A. W. Verreck, Liesbeth van Emst, Esteban M. Rodríguez, Krista G. Haanstra, Simone J.C.F.M. Moorlag, Reinout van Crevel, Jorge Domínguez-Andrés, Richard A. W. Vervenne, Maarten van der Sande, Michel P.M. Vierboom, Carlos Martin, Jelle Thole, Claudia C. Sombroek, Charelle Boot, Karin Dijkman, Mihai G. Netea
Publikováno v:
Cell Reports Medicine, 2, 1
Zaguán: Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Cell Rep Med.
Cell Reports Medicine
Cell Reports Medicine, 2
Zaguán: Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Cell Rep Med.
Cell Reports Medicine
Cell Reports Medicine, 2
Summary BCG vaccination can strengthen protection against pathogens through the induction of epigenetic and metabolic reprogramming of innate immune cells, a process called trained immunity. We and others recently demonstrated that mucosal or intrave
Autor:
Stefan H. E. Kaufmann, Jelle Thole, Carlos A. Guzmán, Helen A. Fletcher, Hans-Joachim Mollenkopf, Odile Leroy, Tom H. M. Ottenhoff, Mark J. Geels, Céline Dutruel
Publikováno v:
Vaccine, 32(35), 4365-4368
High-throughput analyses of RNA and protein expression are increasingly used for better understanding of vaccine-induced immunity and protection against infectious disease. With an increasing number of vaccine candidates in clinical development, it i
Publikováno v:
Vaccine. 31:B223-B226
There are nearly ten million new cases and 1.4 million deaths from tuberculosis (TB) each year, and the 90-year old bacille calmette-guérin (BCG) vaccine in widespread use appears to have minimal impact on the worldwide incidence, despite demonstrat
Autor:
Christian Lienhardt, Clif Barry, Stewart T. Cole, David R. Sherman, Bill Bishai, Richard Hafner, Sabine Ehrt, Stefan H. E. Kaufmann, Dirk Schnappinger, Jelle Thole, Thomas Dick, Paul D. van Helden, Douglas B. Young, Gray Handley, Hanif Esmail, JoAnne L. Flynn, Gilla Kaplan, Brian D. Robertson, Digby F. Warner, Ken Duncan, Gerhard Walzl, Robert J. Wilkinson, Willem A. Hanekom, Peter S. Kim, Christopher Dye, Omar Vandal, Daniel M. Altmann, Eric J. Rubin, Valerie Mizrahi
Publikováno v:
Tuberculosis. 92:447-452
Reduction of active disease by preventive therapy has the potential to make an important contribution towards the goal of tuberculosis (TB) elimination. This report summarises discussions amongst a Working Group convened to consider areas of research
Publikováno v:
Vaccine. 34(26)
TB is now the single pathogen that causes the greatest mortality in the world, at over 1.6 million deaths each year. The widely used the 90 year old BCG vaccine appears to have minimal impact on the worldwide incidence despite some efficacy in infant
Autor:
Jelle Thole, Juraj Ivanyi
This chapter talks about the progress in the study of immune reactions mainly to antigens of Mycobacterium tuberculosis that have been firmly identified and the largely characterized protein structure. An important breakthrough in the characterizatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ecfa7df07140bb6db59f0a20ca8343c
https://doi.org/10.1128/9781555818357.ch26
https://doi.org/10.1128/9781555818357.ch26