TBVAC2020: Advancing Tuberculosis Vaccines from Discovery to Clinical Development

Autor: Stefan H. E. Kaufmann, Hazel M. Dockrell, Nick Drager, Mei Mei Ho, Helen McShane, Olivier Neyrolles, Tom H. M. Ottenhoff, Brij Patel, Danielle Roordink, François Spertini, Steffen Stenger, Jelle Thole, Frank A. W. Verreck, Ann Williams, TBVAC2020 Consortium, Warwick Britton, Jamie Triccas, Claudio Counoupas, Johan Grooten, Marie-Ange Demoitie, Marta Romano, Francoise Mascart, Peter Andersen, Claus Aagaard, Dennis Christensen, Morten Ruhwald, Thomas Lindenstrom, Pierre Charneau, Christophe Guilhot, Antonio Peixoto, Martine Gilleron, Camille Locht, Roland Brosch, Genevieve Inchauspe, Stephane Leung Theung Long, Stefan Kaufmann, January Weiner, Jeroen Maertzdorf, Natalie Neuwenhuizen, Max Bastian, Nadia Caccamo, Delia Goletti, Roberto Nisini, Sung Jae Shin, Hyejon Lee, Alex Sigal, Thomas Scriba, Gerhard Walzl, Andre Loxton, Robert Wilkinson, Pere-Joan Cardona, Cris Vilaplana, Carlos Martin, Dessi Marinova, Nacho Aguilo, Ruedi Aebersold, Etienne Caron, Daniel Pinschewer, Gennaro De Libero, Claire Anne Siegrist, Nicolas Collin, Christophe Barnier-Quer, Peter Sander, Frank Verreck, Tom Ottenhoff, Simone Joosten, Krista van Meijgaarden, Mariateresa Coppola, Annemieke Geluk, Yvonne Perrie, Marc Baird, Michael Levin, Hazel Dockrell, Steven Smith, Helen Fletcher, Gregory Bancroft, Ann Rawkins, Simon Clark, Iman Satti, Elena Stylianou, Martin Vordermeier, Philip Hogarth

Publikováno v: Frontiers in Immunology, Vol 8 (2017)

TBVAC2020 is a research project supported by the Horizon 2020 program of the European Commission (EC). It aims at the discovery and development of novel tuberculosis (TB) vaccines from preclinical research projects to early clinical assessment. The p

Externí odkaz: https://doaj.org/article/c7965df9c6da40b7adb41882e3834949

PhoP: a missing piece in the intricate puzzle of Mycobacterium tuberculosis virulence.

Autor: Jesús Gonzalo-Asensio, Serge Mostowy, Jose Harders-Westerveen, Kris Huygen, Rogelio Hernández-Pando, Jelle Thole, Marcel Behr, Brigitte Gicquel, Carlos Martín

Publikováno v: PLoS ONE, Vol 3, Iss 10, p e3496 (2008)

Inactivation of the transcriptional regulator PhoP results in Mycobacterium tuberculosis attenuation. Preclinical testing has shown that attenuated M. tuberculosis phoP mutants hold promise as safe and effective live vaccine candidates. We focused th

Externí odkaz: https://doaj.org/article/acf078ffa7584179b0b1223916c2ab17

Stronger induction of trained immunity by mucosal BCG or MTBVAC vaccination compared to standard intradermal vaccination

Autor: Sam O. Hofman, Eugenia Puentes, Clemens H. M. Kocken, Joost H.A. Martens, Nacho Aguilo, Frank A. W. Verreck, Liesbeth van Emst, Esteban M. Rodríguez, Krista G. Haanstra, Simone J.C.F.M. Moorlag, Reinout van Crevel, Jorge Domínguez-Andrés, Richard A. W. Vervenne, Maarten van der Sande, Michel P.M. Vierboom, Carlos Martin, Jelle Thole, Claudia C. Sombroek, Charelle Boot, Karin Dijkman, Mihai G. Netea

Publikováno v: Cell Reports Medicine, 2, 1
Zaguán: Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Cell Rep Med.
Cell Reports Medicine
Cell Reports Medicine, 2

Summary BCG vaccination can strengthen protection against pathogens through the induction of epigenetic and metabolic reprogramming of innate immune cells, a process called trained immunity. We and others recently demonstrated that mucosal or intrave

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ce3e7265c370cb7846bfb2713fcc852
https://doi.org/10.1016/j.xcrm.2020.100185

Preventive vaccines for tuberculosis

Autor: Jelle Thole, Thomas G. Evans, Lew Barker, Michael J. Brennan

Publikováno v: Vaccine. 31:B223-B226

There are nearly ten million new cases and 1.4 million deaths from tuberculosis (TB) each year, and the 90-year old bacille calmette-guérin (BCG) vaccine in widespread use appears to have minimal impact on the worldwide incidence, despite demonstrat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8653feada92146ce2eaca50fb05dab3
https://doi.org/10.1016/j.vaccine.2012.11.081

Status of vaccine research and development of vaccines for tuberculosis

Autor: Jelle Thole, Lew Schrager, Thomas G. Evans

Publikováno v: Vaccine. 34(26)

TB is now the single pathogen that causes the greatest mortality in the world, at over 1.6 million deaths each year. The widely used the 90 year old BCG vaccine appears to have minimal impact on the worldwide incidence despite some efficacy in infant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5594b0ae7fb54e4d726e67f2e1107ef8
https://pubmed.ncbi.nlm.nih.gov/26973073