Discovery of a novel highly specific, fully human PSCA antibody and its application as an antibody-drug conjugate in prostate cancer.

Autor: Chu X; Center for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical School, Pittsburgh, PA, USA., Shin S; Center for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical School, Pittsburgh, PA, USA., Baek DS; GLPG, Pittsburgh, PA, USA., Zhang L; Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA., Conard A; GLPG, Pittsburgh, PA, USA., Shi M; Computational and System Biology, School of Medicine, University of Pittsburgh, Pittsburgh, USA., Kim YJ; GLPG, Pittsburgh, PA, USA., Adams C; GLPG, Pittsburgh, PA, USA., Hines M; Center for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical School, Pittsburgh, PA, USA., Liu X; Center for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical School, Pittsburgh, PA, USA., Chen C; Center for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical School, Pittsburgh, PA, USA., Sun Z; GLPG, Pittsburgh, PA, USA., Jelev DV; Center for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical School, Pittsburgh, PA, USA., Mellors JW; Center for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical School, Pittsburgh, PA, USA.; GLPG, Pittsburgh, PA, USA., Dimitrov DS; Center for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical School, Pittsburgh, PA, USA.; GLPG, Pittsburgh, PA, USA., Li W; Center for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical School, Pittsburgh, PA, USA.

Publikováno v: MAbs [MAbs] 2024 Jan-Dec; Vol. 16 (1), pp. 2387240. Date of Electronic Publication: 2024 Aug 08.