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2′-deoxy-ADPR activates human TRPM2 faster than ADPR and thereby induces higher currents at physiological Ca2+ concentrations

Autor: Jelena Pick, Simon Sander, Stefanie Etzold, Anette Rosche, Henning Tidow, Andreas H. Guse, Ralf Fliegert

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

TRPM2 is a Ca2+ permeable, non-selective cation channel in the plasma membrane that is involved in the innate immune response regulating, for example, chemotaxis in neutrophils and cytokine secretion in monocytes and macrophages. The intracellular ad

Externí odkaz: https://doaj.org/article/c5740e9dda0c4bb5b4009932a290188e

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The crystal structure of TRPM2 MHR1 /2 domain reveals a conserved Zn 2+ ‐binding domain essential for structural integrity and channel activity

Autor: Simon Sander, Jelena Pick, Ellen Gattkowski, Ralf Fliegert, Henning Tidow

Publikováno v: Protein Science. 31

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd06e3e0d36602e0845089ff8cee38db
https://doi.org/10.1002/pro.4320

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The crystal structure of TRPM2 MHR1/2 domain reveals a conserved Zn

Autor: Simon, Sander, Jelena, Pick, Ellen, Gattkowski, Ralf, Fliegert, Henning, Tidow

Publikováno v: Protein science : a publication of the Protein Society. 31(6)

Transient receptor potential melastatin 2 (TRPM2) is a Ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::da91cf9cff676333eb0b6355c7e8add7
https://pubmed.ncbi.nlm.nih.gov/35634784

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