Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jelena Medan"'
Autor:
Keith G. Watson, Benny J. Evison, Brad E. Sleebs, Don R. Phillips, Jelena Medan, Suzanne M. Cutts, Kurt Lackovic
Publikováno v:
Bioorganicmedicinal chemistry letters. 35
Current techniques for the identification of DNA adduct-inducing and DNA interstrand crosslinking agents include electrophoretic crosslinking assays, electrophoretic gel shift assays, DNA and RNA stop assays, mass spectrometry-based methods and 32P-p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0ae5ce5bb8656e0213c964940bc8181
https://pubmed.ncbi.nlm.nih.gov/33486050
https://pubmed.ncbi.nlm.nih.gov/33486050
Autor:
Shyam K. Konda, Jelena Medan, J. Grant Collins, Paul P. Pumuye, Brad E. Sleebs, Suzanne M. Cutts, Celine Kelso, Don R. Phillips
Publikováno v:
Organic & Biomolecular Chemistry. 14:4728-4738
The ability of a bis-amino mitoxantrone anticancer drug (named WEHI-150) to form covalent adducts with DNA, after activation by formaldehyde, has been studied by electrospray ionisation mass spectrometry and HPLC. Mass spectrometry results showed tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5bbbd7675d9bb8b11e5c6e8da5f8e96
https://doi.org/10.1039/c6ob00561f
https://doi.org/10.1039/c6ob00561f
Autor:
Brad E. Sleebs, Benny J. Evison, Paul P. Pumuye, Jelena Medan, Celine Kelso, Suzanne M. Cutts, Don R. Phillips, J. Grant Collins, Keith G. Watson, Shyam K. Konda
Publikováno v:
Bioorganic & Medicinal Chemistry. 28:115260
Mitoxantrone is an anticancer anthracenedione that can be activated by formaldehyde to generate covalent drug-DNA adducts. Despite their covalent nature, these DNA lesions are relatively labile. It was recently established that analogues of mitoxantr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff843e1e50e3195bb5a68e5e9272cf8e
https://doi.org/10.1016/j.bmc.2019.115260
https://doi.org/10.1016/j.bmc.2019.115260
Autor:
Nathan J. O'Brien, Ian G. Jennings, Jelena Medan, Syazwani Itri Amran, Benjamin Cleary, Philip E. Thompson, Leslie W. Deady, Belinda M. Abbott
Publikováno v:
ChemMedChem. 8:914-918
Prodrugs for PI3K: A series of substituted analogues of the phosphatidylinositol 3 kinase (PI3K) inhibitor LY294002 were prepared and found to potently inhibit the isolated enzyme but not MCF7 cell proliferation. Two tetrazolyl-substituted analogues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a41a97d565cce9db24298abda0ece7
https://doi.org/10.1002/cmdc.201200583
https://doi.org/10.1002/cmdc.201200583
Autor:
Jelena Medan, J. Grant Collins, Suzanne M. Cutts, Celine Kelso, Shyam K. Konda, Brad E. Sleebs, Don R. Phillips
Publikováno v:
Organicbiomolecular chemistry. 14(43)
The major covalent adduct formed between a 13C-labelled formaldehyde activated bis-amino mitoxantrone analogue (WEHI-150) and the hexanucleotide d(CG5MeCGCG)2 has been isolated by HPLC chromatography and the structure determined by NMR spectroscopy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af1ad6f69d6acbcb09535b11f2c21252
https://pubmed.ncbi.nlm.nih.gov/27735959
https://pubmed.ncbi.nlm.nih.gov/27735959
Autor:
Jelena Medan, Benny J. Evison, Brad E. Sleebs, Paul P. Pumuye, Don R. Phillips, Suzanne M. Cutts, Keith G. Watson
Publikováno v:
Molecular Cancer Therapeutics. 12:C279-C279
DNA has been regarded as the primary target of numerous non-specific cytotoxic anticancer agents such as the nitrogen mustards and anthracycline antibiotics. The anthracyclines, most notably doxorubicin, proved to be highly potent and were thus incor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::463e78838c9369b38c2004ce63e0c295
https://doi.org/10.1158/1535-7163.targ-13-c279
https://doi.org/10.1158/1535-7163.targ-13-c279