Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jelena Jachno"'
Autor:
Jurgita Matulienė, Gediminas Žvinys, Vytautas Petrauskas, Agnė Kvietkauskaitė, Audrius Zakšauskas, Kirill Shubin, Asta Zubrienė, Lina Baranauskienė, Lina Kačenauskaitė, Sergei Kopanchuk, Santa Veiksina, Vaida Paketurytė-Latvė, Joana Smirnovienė, Vaida Juozapaitienė, Aurelija Mickevičiūtė, Vilma Michailovienė, Jelena Jachno, Dovilė Stravinskienė, Aistė Sližienė, Agnė Petrošiūtė, Holger M. Becker, Justina Kazokaitė-Adomaitienė, Ala Yaromina, Edita Čapkauskaitė, Ago Rinken, Virginija Dudutienė, Ludwig J Dubois, Daumantas Matulis
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-25 (2022)
Abstract Numerous human cancers, especially hypoxic solid tumors, express carbonic anhydrase IX (CAIX), a transmembrane protein with its catalytic domain located in the extracellular space. CAIX acidifies the tumor microenvironment, promotes metastas
Externí odkaz:
https://doaj.org/article/37ebb5e55c0a4123a7c8f686b66ab087
Autor:
Audrius Zakšauskas, Edita Čapkauskaitė, Vaida Paketurytė-Latvė, Alexey Smirnov, Janis Leitans, Andris Kazaks, Elviss Dvinskis, Laimonas Stančaitis, Aurelija Mickevičiūtė, Jelena Jachno, Linas Jezepčikas, Vaida Linkuvienė, Andrius Sakalauskas, Elena Manakova, Saulius Gražulis, Jurgita Matulienė, Kaspars Tars, Daumantas Matulis
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1, p 130 (2021)
Among the twelve catalytically active carbonic anhydrase isozymes present in the human body, the CAIX is highly overexpressed in various solid tumors. The enzyme acidifies the tumor microenvironment enabling invasion and metastatic processes. Therefo
Externí odkaz:
https://doaj.org/article/84acb04d62b848db9affb4f5bc5e5838
Autor:
Vilma Michailovienė, Jolanta Torresan, Jelena Jachno, Lina Baranauskienė, Jurgita Matulienė, Daumantas Matulis, Piotras Cimmperman, Asta Zubrienė
Publikováno v:
International Journal of Molecular Sciences, Vol 10, Iss 6, Pp 2662-2680 (2009)
The analysis of tight protein-ligand binding reactions by isothermal titration calorimetry (ITC) and thermal shift assay (TSA) is presented. The binding of radicicol to the N-terminal domain of human heat shock protein 90 (Hsp90aN) and the binding of
Externí odkaz:
https://doaj.org/article/83d783e9738044eeafd24862e1d6ea4c
Autor:
David D. Timm, Jelena Jachno, Saulius Gražulis, Vaida Linkuvienė, Lina Baranauskienė, Asta Zubrienė, Alexey Smirnov, Jurgita Revuckienė, Abdul Waheed, Vilma Michailovienė, Aurelija Mickevičiūtė, Enrico Di Cera, Edita Čapkauskaitė, William S. Sly, Zhiwei Chen, Elena Manakova, Daumantas Matulis, Marius Gedgaudas, Jurgita Matulienė
Publikováno v:
European Biophysics Journal. 47:271-290
Membrane-associated carbonic anhydrase (CA) isoform IV participates in carbon metabolism and pH homeostasis and is implicated in the development of eye diseases such as retinitis pigmentosa and glaucoma. A series of substituted benzenesulfonamides we
Autor:
Jelena Jachno, Aurelija Mickevičiūtė, Vilma Michailovienė, Vaida Juozapaitienė, Daumantas Matulis, Jurgita Matulienė
Publikováno v:
Carbonic Anhydrase as Drug Target ISBN: 9783030127787
Target-based drug design is based on the search of chemical compounds that would strongly and specifically bind to the target protein. The target protein is chosen based on biochemical and cellular investigation of a disease and a demonstration that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::228ce8332edebb623ece0466ddfb08c9
https://doi.org/10.1007/978-3-030-12780-0_2
https://doi.org/10.1007/978-3-030-12780-0_2
Autor:
Vaida Linkuvienė, Vaida Juozapaitienė, Jurgita Matulienė, Vilma Michailovienė, Jelena Jachno, Daumantas Matulis
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1860:708-718
Background Human carbonic anhydrase 9th isoform (CA IX) is an important marker of numerous cancers and is increasingly interesting as a potential anticancer drug target. Various synthetic aromatic sulfonamide-bearing compounds are being designed as p
Autor:
Carolina dos Santos Passos, Pierre-Alain Carrupt, Daumantas Matulis, Alessandra Nurisso, Jelena Jachno, Lucie Ryckewaert, Claudia A. Simões-Pires, Lionel Sacconnay, Giuseppe Marco Randazzo, Vilma Michailovienė, Asta Zubrienė, Charlotte Petit
Publikováno v:
European Journal of Pharmaceutical Sciences. 85:59-67
Sirtuins (SIRTs) are a family of enzymes able to catalyze the deacetylation of the N-acetyl lysines of both histone and non-histone substrates. Inhibition of SIRTs catalytic activity was recently reported in the literature as being beneficial in huma
Autor:
Rasa Sukackaitė, Jolanta Torresan, Dmitrij Golovenko, Lina Baranauskienė, Vilma Michailovienė, Saulius Gražulis, Jurgis Sūdžius, Sigitas Tumkevicius, Jurgita Matulienė, Jelena Jachno, Elena Manakova, Daumantas Matulis
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:7413-7421
A series of 4-[N-(substituted 4-pyrimidinyl)amino]benzenesulfonamides were designed and synthesised. Their binding potencies as inhibitors of selected recombinant human carbonic anhydrase (hCA) isozymes I, II, VII, and XIII were measured using isothe
Autor:
Daumantas Matulis, Jelena Jachno, Vilma Michailoviene, Egidijus Kazlauskas, Jurgita Matuliene, Jolanta Torresan, Inga Cikotiene
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1089-1092
A series of 5-aryl-4-(5-substituted-2,4-dihydroxyphenyl)-1,2,3-thiadiazoles were synthesized and their binding to several constructs of human Hsp90 chaperone measured by isothermal titration calorimetry (ITC). The most potent compound bound Hsp90 wit
Autor:
Elena Manakova, Asta Zubrienė, Alexey Smirnov, Vilma Michailovienė, Saulius Gražulis, Daumantas Matulis, Joana Smirnovienė, Povilas Norvaisas, Vaida Juozapaitienė, Jelena Jachno, Vaida Morkūnaitė
Publikováno v:
Biophysical chemistry. 205
Para substituted tetrafluorobenzenesulfonamides bind to carbonic anhydrases (CAs) extremely tightly and exhibit some of the strongest known protein-small ligand interactions, reaching an intrinsic affinity of 2 pM as determined by displacement isothe