Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jelena Beljantseva"'
Autor:
Liis Andresen, Jelena Beljantseva, Tanel Tenson, Victoria Shingler, Pavel Kudrin, Gemma C. Atkinson, Vasili Hauryliuk
Publikováno v:
Proceedings of the National Academy of Sciences
The alarmone nucleotides guanosine pentaphosphate (pppGpp) and tetraphosphate (ppGpp), collectively referred to as (p)ppGpp, are key regulators of bacterial growth, stress adaptation, pathogenicity, and antibiotic tolerance. We show that the tetramer
Autor:
Martin Saxtorph Bojer, Melek Cemre Manav, Jelena Beljantseva, Vasili Hauryliuk, Tanel Tenson, Hanne Ingmer, Ditlev E. Brodersen
Publikováno v:
Journal of Biological Chemistry
Manav, M C, Beljantseva, J, Bojer, M S, Tenson, T, Ingmer, H, Hauryliuk, V & Brodersen, D E 2018, ' Structural basis for (p)ppGpp synthesis by the Staphylococcus aureus small alarmone synthetase RelP ', Journal of Biological Chemistry, vol. 293, no. 9, pp. 3254-3264 . https://doi.org/10.1074/jbc.RA117.001374
The journal of biological chemistry 293(9), 3254-3264 (2018). doi:10.1074/jbc.RA117.001374
Manav, M C, Beljantseva, J, Bojer, M S, Tenson, T, Ingmer, H, Hauryliuk, V & Brodersen, D E 2018, ' Structural basis for (p)ppGpp synthesis by the Staphylococcus aureus small alarmone synthetase RelP ', Journal of Biological Chemistry, vol. 293, no. 9, pp. 3254-3264 . https://doi.org/10.1074/jbc.RA117.001374
The journal of biological chemistry 293(9), 3254-3264 (2018). doi:10.1074/jbc.RA117.001374
The stringent response is a global reprogramming of bacterial physiology that renders cells more tolerant to antibiotics and induces virulence gene expression in pathogens in response to stress. This process is driven by accumulation of the intracell
Autor:
Pavel Kudrin, Roshani Payoe, Andrey L. Konevega, Kensuke Ishiguro, Jelena Beljantseva, Tanel Tenson, Vasili Hauryliuk, Vallo Varik, Elena Maksimova, Ievgen Dzhygyr, Sofia Raquel Alves Oliveira, Tsutomu Suzuki
Publikováno v:
Nucleic Acids Research
During amino acid starvation the Escherichia coli stringent response factor RelA recognizes deacylated tRNA in the ribosomal A-site. This interaction activates RelA-mediated synthesis of alarmone nucleotides pppGpp and ppGpp, collectively referred to
Autor:
Felipe Cava, Tanel Tenson, Vallo Varik, Ievgen Dzhygyr, Vasili Hauryliuk, Sofia Raquel Alves Oliveira, Jelena Beljantseva, Teresa del Peso Santos, Pavel Kudrin, Dominik Rejman
Publikováno v:
Antimicrobial Agents and Chemotherapy
The nucleotide (p)ppGpp is a key regulator of bacterial metabolism, growth, stress tolerance, and virulence. During amino acid starvation, the Escherichia coli (p)ppGpp synthetase RelA is activated by deacylated tRNA in the ribosomal A-site. An incre
Autor:
Dominik Rejman, Tanel Tenson, Jelena Beljantseva, Victoria Shingler, Vallo Varik, Steffi Jimmy, Vasili Hauryliuk, Radek Pohl, Yuzuru Tozawa, Marcel Ehn, Pavel Kudrin
Publikováno v:
Scientific Reports
The alarmone nucleotide (p)ppGpp is a key regulator of bacterial metabolism, growth, stress tolerance and virulence, making (p)ppGpp-mediated signaling a promising target for development of antibacterials. Although ppGpp itself is an activator of the
Autor:
Anthony O. Gaca, Jelena Beljantseva, José A. Lemos, Brent W. Anderson, Katarzyna Potrykus, Kuanqing Liu, Cristina Colomer-Winter, Vasili Hauryliuk, Pavel Kudrin, Dominik Rejman, Jue D. Wang, Michael Cashel
The bacterial stringent response (SR) is a conserved stress tolerance mechanism that orchestrates physiological alterations to enhance cell survival. This response is mediated by the intracellular accumulation of the alarmones pppGpp and ppGpp, colle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4fdfc45f85ca3515be9b2cd9a48b9e7
https://europepmc.org/articles/PMC4542164/
https://europepmc.org/articles/PMC4542164/