Výsledky vyhledávání - "Jelena Barbulovic"

Abstract LB-141: Specific and potent silencing of K-Ras by asymmetric silencing RNA (aiRNA) reveals addiction of cancer stem cells to mutant K-Ras amplification

Autor: Nithya Jesuraj, Jun Oishi, Xiangao Sun, Chiang J. Li, Jelena Barbulovic, Hiroki Umehara

Publikováno v: Cancer Research. 75:LB-141

K-Ras, the first oncogene identified in human cancer, is mutated in about 30% of human solid tumors. K-Ras protein, a small membrane-bound GTP-binding protein, acts as a molecular switch to transduce cell proliferation signals. Activating mutations o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a57e3be0631215617444b850abb5fd0e
https://doi.org/10.1158/1538-7445.am2015-lb-141

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Abstract LB-47: Specific and potent silencing of K-Ras by asymmetric RNA technology reveals addiction of gastric cancer stem cells

Autor: Jelena Barbulovic, Youzhi Li, Nithya Jesuraj, Jun Oishi, Chiang Li, Xiaoshu Dai, Xiangao Sun, Keyur Gada, Hiroki Umehara

Publikováno v: Cancer Research. 74:LB-47

The protein K-Ras is a molecular switch that under normal conditions regulates cell growth and cell division. Mutations in this protein lead to the formation of tumors through continuous cell growth. About 30% of human cancers have a mutated Ras prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e9cc41af1499de14dd25aed5124531d0
https://doi.org/10.1158/1538-7445.am2014-lb-47

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